6 Hydroxydopamine
Mostrando 1-12 de 101 artigos, teses e dissertações.
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1. Acute Physical Stress Preconditions the Heart Against Ischemia/Reperfusion Injury Through Activation of Sympathetic Nervous System
Resumo Fundamento: O estresse é definido como um estado complicado de distúrbios da homeostase, hiperatividade do sistema nervoso simpático e das respostas do eixo hipotálamo-hipófise-adrenal. O pré-condicionamento cardíaco diminui os danos do miocárdio. Objetivo: Esse estudo avaliou os efeitos cardioprotetores do estresse físico agudo contra a le
Arq. Bras. Cardiol.. Publicado em: 10/10/2019
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2. Neuroprotective effect of Portulaca oleracea extracts against 6-hydroxydopamine-induced lesion of dopaminergic neurons
RESUMO A Portulaca oleracea L. (Portulacaceae) é uma espécie cosmopolita com uma vasta gama de atividades biológicas, incluindo as ações antioxidante e neuroprotetora. No presente trabalho foram investigados os efeitos do tratamento com extratos de P. oleracea em modelo animal (aplicação de 6-hidroxidopamina) para estudo da doença de Parkinson, uma d
An. Acad. Bras. Ciênc.. Publicado em: 04/08/2016
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3. Antioxidant Activity of Oral Administration of Rosmarinus Officinalis Leaves Extract on Rat's Hippocampus which Exposed to 6-Hydroxydopamine
Carnosic acid, a diterpene of Rosemarinus officinalis leaves extract (RE), has potent antioxidant activity in vitro. The dopaminergic connection of substantia nigra pars compacta to the hippocampus might be affected by oxidative stress which caused cognitive impairment observed in the early phase of Parkinson's disease (PD). Adult male Wistar rats were lesio
Braz. arch. biol. technol.. Publicado em: 29/04/2016
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4. Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat
PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using
Acta Cir. Bras.. Publicado em: 2016-02
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5. 6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure
Impaired temporal control is symptomatic of several neurological disorders; recently, it has been implicated in schizophrenia. An animal model of schizophrenia using 6-hydroxydopamine (6-OHDA) infused to the medial pre-frontal cortex (mPFC) was employed to examine its effects on temporal control. Twelve rats were trained on a peak-interval procedure (PIP) un
Psychol. Neurosci.. Publicado em: 06/06/2014
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6. Avaliação dos Movimentos Periódicos Das Patas Na Síndrome Das Pernas Inquietas, Utilizando Um Modelo Animal Induzido Pela Lesão Do Núcleo Dopaminérgico A11 Com A 6-Hidroxidopamina / Evaluation of Periodic Limb Movements in Restless Legs Syndrome, using an animal model induced by Injury of A11 dopamine nucleus with 6-Hydroxydopamine
Background: Restless Legs Syndrome (RLS) is a major healthcare burden of increasing prevalence. It has been demonstrated that periodic limb movements in sleep (PLM) can occur as an isolated phenomenon, but they are often associated with RLS and represent the only symptom of this disorder that can be measured electrophysiologically. The aim of this study was
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2011
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7. Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl- D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 μg 6-OHDA (6-OHDA group) or vehicle (artificial cerebrospinal
Publicado em: 2011
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8. Fatores interferentes na indução da atividade rotacional induzida pelo teste de motricidade sobre grade em modelo animal da doença de Parkinson
Parkinson s disease (PD) is a progressive neurodegenerative disorder that affects 1% of the population above 55 years. In a previous work, it was shown that the footfault test is a tool for screening highly lesioned rats in modeling for PD using the toxin 6-hydroxydopamine (6-OHDA), which is widely used, by observing whether animals present or not context-in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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9. Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl-D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 mg 6-OHDA (6-OHDA group) or vehicle (artificial cerebrospinal fl
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-01
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10. Influência da adrenalectomia bilateral nos eventos neurodegenerativos no modelo do parkinsonismo experimental pela 6-OHDA nigral. Enfoque aos mecanismos parácrinos gliais envolvidos na neuroproteção e cicatrização / Text not informed by the author
This study has the objective to evaluate the effect of the bilateral adrenalectomy in the neurodegenerative process and cicatrization on the nigroestriatal pathway injury through 6-hydroxydopamine (6-OHDA) in rat, and in this way contribute for the interpretation of the adreno esteroides hormones effects in the neurodegenerative and neurotrophics process in
Publicado em: 2009
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11. Neuroprotective effect of ketamine/xylazine on two rat models of Parkinson's disease
There is a great concern in the literature for the development of neuroprotectant drugs to treat Parkinson's disease. Since anesthetic drugs have hyperpolarizing properties, they can possibly act as neuroprotectants. In the present study, we have investigated the neuroprotective effect of a mixture of ketamine (85 mg/kg) and xylazine (3 mg/kg) (K/X) on the 1
Brazilian Journal of Medical and Biological Research. Publicado em: 13/12/2006
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12. Chalcones isolated from myracrodruon urundeuva and 2-methyl-inositol isolated from Magonia glabrata protect neurons from 6-hydroxydopamine-induced oxidative injury and apoptose: study in rat mesencephalic cell cultures / Chalconas isoladas da myracrodruon urundeuva e 2-O-metilinositol isolado da magonia glabrata protegem neurônios de danos oxidativos e apoptose induzida por 6-hidroxidopamina (6-OHDA): estudo em cultura primária de células mesencefálicas de ratos
The present work evaluated the cytoprotective effect of chalcone-enriched fraction (CEF) and 2-methyl-inositol (MIT) in primary rat mesencephalic cell culture exposed to the neurotoxin 6-hydroxydopamine (6-OHDA). The CEF was obtained from Myracrodruon urundeuva, a Brazilian medicinal plant used as an antiinflamatory and wound healing agent.in female genital
Publicado em: 2005