5ht Receptors
Mostrando 13-24 de 219 artigos, teses e dissertações.
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13. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO / ANTIDEPRESSANT-LIKE PHARMACOLOGICAL PROFILE OF 3-(4- FLUOROPHENYLSELENYL)-2,5-DIPHENYLSELENOPHENE: INVOLVEMENT OF SEROTONERGIC SYSTEM
Depression is a serious, recurrent and incapacitating psychiatric condition with a heavy social burden. The pharmacological approach to this disorder employs therapy with antidepressant drugs, which have side effects and numerous limitations. In view of the promising pharmacological properties of containing-selenium molecules, this study evaluated the effect
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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14. Central 5-HT2A receptors modulate the vagal bradycardia in response to activation of the von Bezold-Jarisch reflex in anesthetized rats
Activation of 5-hydroxytryptamine (5-HT) 5-HT1A, 5-HT2C, 5-HT3, and 5-HT7 receptors modulates the excitability of cardiac vagal motoneurones, but the precise role of 5-HT2A/2B receptors in these phenomena is unclear. We report here the effects of intracisternal (ic) administration of selective 5-HT2A/2B antagonists on the vagal bradycardia elicited by activa
Braz J Med Biol Res. Publicado em: 2011-03
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15. Planejamento, síntese, biotransformação e avaliação farmacológica de novos candidatos a protótipos de fármacos antipsicóticos / Planning, synthesis, biotransformation and pharmacological evaluation of new candidate prototype antipsychotic drugs
In the scope of a research program that aim the design, synthesis and pharmacological evaluation of new lead-compounds, we will describe in this work the design of new N-phenylpiperazines derivatives originally designed from clozapine (27) and LASSBio 579 (40) that shows antagonist profile in dopaminergic receptors. The compound 1-(4-nitrophenyl)-4-((1-pheny
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2010
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16. Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
This study investigated the behavioral effects in the forced swim test (FST) and the elevated plus-maze (EPM) of acute administration of WAY 161503 ([4aR]-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5[6 H]-one), a selective 5-HT2C receptor agonist with putative antidepressant-like properties. Fifteen minutes after intraperitoneal (i.p.) inj
Psychology & Neuroscience. Publicado em: 2010-12
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17. Envolvimento dos receptores 5-HT2c do hipocampo ventral na modulação de estados de ansiedade em ratos
The present study investigated the effects of pharmacological blockade of 5-HT2C receptors of the ventral hippocampus (VH) on anxiety levels of rats induced by 5-HT2C agonists. Ten minutes after intraperitoneal (i.p.) injections of either saline (0.9%) or the 5-HT2C agonist WAY-161503 (3mg/kg), rats were bilaterally microinjected in the VH with saline or wit
Publicado em: 2010
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18. Avaliação dos receptores 5-HT2C na expressão da sensibilização comportamental ao efeito estimulante do etanol. / Evaluation of 5-HT2C receptors on the expression of behavioral sensitization to the stimulant effect of ethanol
Não consta abstract.
Publicado em: 2010
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19. Administração do 8-OH-DPAT no septo dorso lateral de camundongos submetidos ao labirinto em cruz elevado promove efeito ansiolítico que é revertido pelo prétratamento local com WAY100635
Research on anxiety often involves the use of animal models for investigation of therapeutic compounds. Thus, the elevated plus maze (EPM) is one of the most commonly model used in research involving anxiety and it has been validated for rats and mice. Serotonin (5-HT) is a neurotransmitter involved not only in anxiety but also in other disorders. Some repor
Publicado em: 2010
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20. Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats
Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor a
Publicado em: 2010
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21. Atividade antinociceptiva e antitumoral de compostos isolados da Pterodon pubescens Benth. (Leguminosae- papilionoidea) / Antinociceptive and antitumor activity of compounds isolated from Pterodon pubescens Benth. (Leguminosae- papilionoidea)
Pterodon pubescens Benth. species is widespread used in folk medicine. In this study, we demonstrated the antinociceptive (analgesic) and anti-tumor activity of compounds isolated from species. The most relevant results were: 1) bioactivityguided fractionation, isolation and identification of compounds using in vitro and in vivo assays; 2) identification of
Publicado em: 2010
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22. Administração prolongada do ácido 13-cis-retinóico (isotretinoína) em camundongos machos adolescentes: comportamentos emocionais e quantificação de transcritos de componentes do sistema serotoninérgico central. / Chronic administration of 13-cis-retinoic acid (isotretinoin) in young male mice: emotion-related behaviors and quantification of central serotonergic system transcripts.
O ácido 13-cis-retinóico (13-cis-RA, isotretinoína) é um retinóide sintético de uso oral prolongado, prescrito em altas doses, para o tratamento da acne. Age primariamente diminuindo a atividade da glândula sebácea e reduzindo a inflamação. Desde a aprovação do uso do 13-cis-RA, tem-se relatos na literatura de sintomas psiquiátricos incluindo de
Publicado em: 2010
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23. Núcleo mediano da rafe e estresse de nado forçado: papel dos receptores de glutamato de tipo NMDA / Median Raphe Nucleus and Forced Swim stress: role of glutamate NMDA receptors
Exposure to uncontrollable stressors leads to behavioral and neurochemical changes, which has been associated to mal functioning of the Median Raphe Nucleus (MnRN)-Dorsal Hippocampus (DH) serotoninergic pathway. These deficits can be attenuated by intra-hippocampal injections of NMDA antagonists or 5-HT1a agonists. Activation of MnRN glutamatergic NMDA recep
Publicado em: 2010
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24. Avaliação dos mecanismos determinantes dos efeitos cardiovasculares promovidos pelo IM-7 em ratos com hipertensão induzida pelo L-NAME : abordagens in vivo e in vitro / Evaluation of determinant mechanisms involved in cardiovascular effects induced by IM-7 in L-NAME hypertensive rats: In vivo and in vitro approaches
Derivados imidazolidínicos apresentam uma ampla variedade de atividades biológicas, dentre elas a antiarrítmica e anti-hipertensiva. O efeito vasorerrelaxante de seis derivados hidantoínicos foi avaliado neste estudo. Dentre estas substâncias, os efeitos cardiovasculares induzidos por IM-7 foram avaliados empregando-se abordagens in vivo e in vitro. Em
Publicado em: 2010