5 Lipoxygenase
Mostrando 13-24 de 242 artigos, teses e dissertações.
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13. Comparison of pre- versus post-incision administration of intraplantar indomethacin and MK886 in a rat model of postoperative pain
The amplification of pain long after the initial stimulus may be avoided if the treatment of pain is introduced before its initiation. However, conflicting evidence exists about the efficacy of such preemptive analgesia for the management of postoperative pain. This study compares the efficacy of intraplantar administration of indomethacin (a non-selective i
Brazilian Journal of Medical and Biological Research. Publicado em: 22/06/2007
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14. Effect of the cysteinyl-leukotrienes on the production of eosinophils in culture of bone marrow: direct actions, mediation of the actions of the indometacina and the aspirin, and regulation of the reply to the PGE2. / Efeitos dos cisteinil-leucotrienos sobre a produção de eosinófilos em cultura de medula óssea: ações diretas, mediação das ações da indometacina e da aspirina, e regulação da resposta à PGE2.
Cysteinyl-Leukotrienes (CysLT) are important mediators of asthma, which induce bronchoconstriction, mucus secretion and a variety of regulatory effects on the infiltrating leukocyte populations, especially eosinophils. Increased CysLT production resulting from the shunting of arachidonic acid towards the 5-lipoxygenase (5-LO) pathway in the absence of active
Publicado em: 2007
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15. Papel da 5-Lipoxigenase no controle da carga parasitária e no estresse oxidaltivo de eritrócitos durante a fase aguda da infecção experimental com Trypanosoma cruzi
Recently, it was demonstrated that nitric oxide (NO) produced during Trypanosoma cruzi infection participates of erythrocyte oxidative stress, but is not necessary for the development of anemia in the acute phase of infection in mice. In this work it was investigated the effect of inhibition of leukotrienes (LTs) by pharmacological or genetic blocking of the
Publicado em: 2007
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16. Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom
Inflammatory response induced by the venom of the Arabian sand viper Cerastes gasperettii was studied by measuring rat hind-paw edema. Cerastes gasperettii venom (CgV, 3.75-240 µg/paw), heated for 30s at 97°C, caused a marked dose and time-dependent edema in rat paw. Response was maximal 2h after venom administration and ceased within 24h. Heated CgV was r
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2006
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17. Mecanismos de formação papel dos corpúsculos lipídicos nos eosinófilos na resposta inflamatória alergica / Mechanisms of fomatiom of the Paper of the Lipid Bodies in Eosinophils in the allergic inflammatory response
Lipid bodies are lipid-rich cytoplasmic inclusions, which are candidates to play a major role in the formation of eicosanoid mediators during inflammatory response. Lipid body formation/function in vivo at sites of allergic inflammation were never investigated. Here, we studied lipid body formation in vivo within eosinophils recruited to sites of allergic in
Publicado em: 2006
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18. Biological activity of the aqueous extract of Lychnophora pinaster Mart.
Lyophilized aqueous extract (LAE) from Lychnophora pinaster Mart (Asteraceae) aerial parts was evaluated in the search of possible biological activities. LAE exhibited trypanocidal activity (113.62 mg/mL), but could not inhibit 5-lipoxygenase in vitro (17% of inhibition). LAE chemical characterization by HPLC with UV-Diode Array Detector showed the presence
Revista Brasileira de Farmacognosia. Publicado em: 2005-12
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19. Aspectos quÃmico, fÃsico-quÃmico e sensorial de extratos de soja e tofus obtidos dos cultivares de soja convencional e livre de lipoxigenase / Technological, physicochemical, biochemical and sensorial studies of soybean extracts and respective tofus obtained from conventional and lipoxygenase-free soybean cultivars. / Technological, physicochemical, biochemical and sensorial studies of soybean extracts and respective tofus obtained from conventional and lipoxygenase-free soybean cultivars. / Aspectos quÃmico, fÃsico-quÃmico e sensorial de extratos de soja e tofus obtidos dos cultivares de soja convencional e livre de lipoxigenase
The work was conducted in the laboratories of the Food Science Department of the Federal University of Lavras âMG. Soybean grains [Glycine max (l) Merrill] utilized were: conventional cultivar BRS 133 and cultivar BRS 213, genetically improved and suitable for human consumption, lipoxygenase-free, granted by Embrapa-Soja PR. For reasons proved, soybean cons
Publicado em: 2004
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20. Stimulatory effects of adenosine on prolactin secretion in the pituitary gland of the rat
We investigated the effects of adenosine on prolactin (PRL) secretion from rat anterior pituitaries incubated in vitro. The administration of 5-N-methylcarboxamidoadenosine (MECA), an analog agonist that preferentially activates A2 receptors, induced a dose-dependent (1 nM to 1 µM) increase in the levels of PRL released, an effect abolished by 1,3-dipropyl-
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-07
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21. Estudo das atividades edematogenica e hemorragica do veneno de Bothrops Lanceolatus em ratos
The ability of snake venoms to induce local effects is well known. In this thesis, the oedema and hemorrhage induced in rats by heated and non-heated Bothrops lanceolatus venom (BL V) was investigated. Oedema was induced by the subplantar injection of venom (12.5-100 µg/paw) and was quantified by hydroplethysmography at various times thereafter. Hemorrhage
Publicado em: 1996
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22. Estudo comparativo da resposta inflamatoria, em ratos, induzida por venenos de serpentes do genero Bothrops em estagios distintos de desenvolvimento
This thesis examines the inflammatory response induced in the rat peritoneal cavity and in the rat hind paw by the venom obtained from young and adult specimens of Bothrops jararaca; B. neuwiedi and B. moojeni. The venoms of adult B. moojeni (BMV), B. jararaca (BN) and B neuwiedi (BNV) induced dose-dependent neutrophil migration into the rat peritoneal cavit
Publicado em: 1994
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23. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis
Oxidation products of low-density lipoproteins have been suggested to promote inflammation during atherogenesis, and reticulocyte-type 15-lipoxygenase has been implicated to mediate this oxidation. In addition, the 5-lipoxygenase cascade leads to formation of leukotrienes, which exhibit strong proinflammatory activities in cardiovascular tissues. Here, we st
The National Academy of Sciences.
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24. Characterization of Two Isoenzymes of Lipoxygenase from Bush Beans 1
Two isoenzymes of lipoxygenase, a and b, have been obtained from bush beans (Phaseolus vulgaris) as electrophoretically homogeneous proteins. Both proteins have a molecular weight of 100,000, contain 1 atom of iron, and appear to be composed of a single peptide chain. However, these enzymes appear to differ in some other respects. Thus, lipoxygenase a has an