5 Lipoxygenase
Mostrando 1-12 de 242 artigos, teses e dissertações.
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1. Isolation, in vitro and in silico Evaluation of Phenylethanoid Glycoside from Arrabidaea brachypoda as Lipoxygenase Inhibitor
Lipoxygenase (LOX) plays an important role in inflammatory processes and Arrabidaea brachypoda (DC.) Bureau (Bignoniaceae) has been described as presenting anti-inflammatory activity. Therefore, the objective of this study was to develop a high-performance liquid chromatography (HPLC) procedure to directly recognize LOX inhibitor compounds in A. brachypoda c
J. Braz. Chem. Soc.. Publicado em: 2020-04
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2. Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones
It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibiotic resistance modifiers. Two chalcones with catecholic moieties
J. Braz. Chem. Soc.. Publicado em: 2019-02
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3. Lipoxygenase inhibitors flavonoids from Cyperus rotundus aerial parts
ABSTRACT Cyperus rotundus L. (Suada, Sueda, family: Cyperaceae) is vastly spread in several world's subtropical and tropical regions. It had variable traditional uses and bioactivities. A new flavonol derivative: cyperaflavoside (myricetin 3,3',5'-trimethyl ether 7-O-β-D-glucopyranoside) and five flavonoids: vitexin, orientin, cinaroside, quercetin 3-O-β-D
Rev. bras. farmacogn.. Publicado em: 2018-06
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4. Anti-inflammatory and antioxidant activities of the Impatiens noli-tangere and Stachys officinalis polyphenolic-rich extracts
ABSTRACT This study evaluated the anti-inflammatory and antioxidant activities of Impatiens noli-tangere L., Balsaminaceae, and of Stachys officinalis L., Lamiaceae, polyphenolic-rich extracts obtained by nanofiltration process. Results showed the great potential and efficiency of the nanofiltration process to concentrate the herbal extract's main polyphenol
Rev. bras. farmacogn.. Publicado em: 2018-01
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5. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect
Abstract Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acut
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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6. Synthesis, spectral analysis and pharmacological study of N'- substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides
ABSTRACT A series of molecules bearing multiple functional groups were synthesized to study their antibiotic effect against Gram-positive and Gram-negative bacteria and lipoxygenase activity as well. 2,4-Dimethylcarbolic acid (1) was refluxed with ethyl 2-bromoacetate to synthesize ethyl 2-(2,4-dimethylphenoxy)acetate (2). Compound 2 was converted to the cor
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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7. Ciclooxigenase-2 modula in vivo a expressão de marcadores da osteoclastogênese e genes envolvidos no metabolismo ósseo em resposta ao lipopolissacarídeo bacteriano / Ciclooxygenase-2 modulates in vivo the expression of osteoclastiogenesis makers and genes involved in bone metabolism in response to bacterial lipopolysaccharide
During an inflammatory response, several mediators are locally released in order to stimulate cellular and humoral immune response. Through the action of cyclooxygenase and lipoxygenase enzymes structural changes occur in the arachidonic acid chain leading to synthesis of prostaglandins or leukotrienes and lipoxins, respectively. Such mediators are responsib
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/06/2012
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8. Papel de SOCS2 na resposta imune e função cardíaca durante a infecção experimental por Trypanosoma cruzi
Infection with Trypanosoma cruzi induces robust inflammation that limits parasite proliferation but may result in Chagas heart disease. The 5-Lipoxygenase pathway induces suppressor of cytokine signaling(SOCS)2 expression, an important regulator of immune responses. Here, we investigated the role of SOCS2 for the pathogenesis of T. cruzi infection. We invest
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011
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9. Lipoxygenase activities during development of root and nodule of soybean.
The objective of this work was to evaluate root and nodule soybean lipoxygenases in Doko cultivar and in a near isogenic line lacking seed lipoxygenases, inoculated and uninoculated with Bradyrhizobium elkanii. The lipoxygenase activities from roots collected at 3, 5, 9, 13, 18 and 28 days post-inoculation and from nodules collected at 13, 18 and 28 days pos
Pesquisa Agropecuária Brasileira. Publicado em: 2011
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10. Aceitabilidade de bebidas preparadas a partir de diferentes extratos hidrossolúveis de soja
O objetivo deste trabalho foi avaliar a aceitabiliade de bebidas obtidas de extrato de soja em pó, produzido a partir de cultivar desprovida de enzimas lipoxigenases, e de dois extratos em pó comerciais. Duas bebidas do extrato da cultivar desprovida de lipoxigenases foram preparadas pela diluição em água mineral a 5 e 10%. Os extratos comerciais foram
Pesquisa Agropecuária Brasileira. Publicado em: 2011
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11. Componentes da resposta inflamatória aguda que favorecem a progressão do melanoma e, modelo murino. / Components of the acute inflammatory response that promote the progression of melanoma in a murine model
Chronic inflammation is one of the main factors that predispose to cancer development and contribute to tumor progression. However, some studies show that acute inflammation is also able to generate a microenvironment favorable to the growth of certain tumors. In our laboratory, Correa et al. showed that injection of a large amount of apoptotic cells creates
Publicado em: 2009
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12. Novas Tiazolidinadionas 3, 5-Dissubstituidas: sÃntese, comprovaÃÃo estrutural e avaliaÃÃo da atividade antiinflamatÃria
To the thiazolidinic nucleus, due to their chemical reactivity, are atributed several biological activities, fact that directed our research in search of new biologically active agents. Recent studies have demonstrated the potential of thiazolidinics derivatives in inhibiting the inflammatory response, characterized by the release of various endogenous pro-i
Publicado em: 2008