5 Indomethacin
Mostrando 13-24 de 336 artigos, teses e dissertações.
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13. Ciclooxigenase-2 modula in vivo a expressão de marcadores da osteoclastogênese e genes envolvidos no metabolismo ósseo em resposta ao lipopolissacarídeo bacteriano / Ciclooxygenase-2 modulates in vivo the expression of osteoclastiogenesis makers and genes involved in bone metabolism in response to bacterial lipopolysaccharide
During an inflammatory response, several mediators are locally released in order to stimulate cellular and humoral immune response. Through the action of cyclooxygenase and lipoxygenase enzymes structural changes occur in the arachidonic acid chain leading to synthesis of prostaglandins or leukotrienes and lipoxins, respectively. Such mediators are responsib
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/06/2012
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14. Complexos metálicos de hidrazonas, tiossemicarbazonas e lapachol: atividade farmacológica e avaliação de relações estrutura-atividade
The present work comprises the synthesis and characterization of metal compounds with bioactive ligands and the study of their pharmacological profile. Anti-inflammatory, antimicrobial, antiparasitic and antitumor drug candidates were designed. Complex [Zn(LASSBio-466)H2O]2 was synthesized with salicylaldehyde-2-chlorobenzoyl hydrazone (H2LASSBio-466), while
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/02/2012
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15. Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used extensively to control inflammatory pain. Several peripheral antinociceptive mechanisms have been described, such as opioid system and NO/cGMP/KATP pathway activation. There is evidence that the cannabinoid system can also contribute to the in vivo pharmacological effects of ibuprofen and indometha
Braz J Med Biol Res. Publicado em: 2012-12
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16. Development of hydroethanolic extract of Ipomoea pes-caprae using factorial design followed by antinociceptive and anti-inflammatory evaluation
Ipomoea pes-caprae (L.) R. Br., Convolvulaceae, is a medicinal plant that grows abundantly as a pan-tropical stand plant. The 3² (two factors and three levels) factorial design, was applied to determine the best time and drug/solvent proportion to maximize the flavonoid content in the hydroethanolic extract by maceration process. The antinociceptive and ant
Rev. bras. farmacogn.. Publicado em: 06/11/2012
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17. Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida
The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectivel
Revista Brasileira de Farmacognosia. Publicado em: 09/01/2012
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18. Obtenção e caracterização do extrato seco Padronizado de Vernonanthura ferruginea (LESS.) H. Rob., Asteraceae (Assa-Peixe) / Obtaining and chacterization of santadardized dry extract of Vernonanthura ferruginea (LESS.) H. Rob., Asteraceae
Vernonanthura ferruginea (Less.) H. Rob. (Asteraceae), a typical plant of the Brazilian savannah, popularly known as assa-peixe, presented analgesic, antiedematogenic, antioxidant and antiulcer activities in scientific studies. But in literature there are no works related to the production of dried extracts of this plant species. In this work, standardized s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/04/2011
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19. Obtenção e caracterização do extrato seco Padronizado de Vernonanthura ferruginea (LESS.) H. Rob., Asteraceae (Assa-Peixe) / Obtaining and chacterization of santadardized dry extract of Vernonanthura ferruginea (LESS.) H. Rob., Asteraceae
Vernonanthura ferruginea (Less.) H. Rob. (Asteraceae), a typical plant of the Brazilian savannah, popularly known as assa-peixe, presented analgesic, antiedematogenic, antioxidant and antiulcer activities in scientific studies. But in literature there are no works related to the production of dried extracts of this plant species. In this work, standardized s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/04/2011
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20. Anti-inflammatory and analgesic potential of Caesalpinia ferrea
Caesalpinia ferrea Mart. belongs to the family Fabaceae. Known as pau-ferro and jucá, it is used in folk medicine to treat diabetes, as antipyretic and antirheumatic. This study aimed to evaluate the anti-inflammatory and antinociceptive activities of the ethanol extract of the fruits of C. ferrea (EECf). In the evaluation of anti-inflammatory activity, EEC
Revista Brasileira de Farmacognosia. Publicado em: 01/11/2011
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21. Acute lead-induced vasoconstriction in the vascular beds of isolated perfused rat tails is endothelium-dependent
Chronic lead exposure induces hypertension in humans and animals, affecting endothelial function. However, studies concerning acute cardiovascular effects are lacking. We investigated the effects of acute administration of a high concentration of lead acetate (100 µΜ) on the pressor response to phenylephrine (PHE) in the tail vascular bed of male Wistar ra
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
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22. Efeitos farmacolÃgicos da Esculina em modelos animais de lesÃo gÃstrica e possÃveis mecanismos envolvidos. / Pharmacologicals effects of the esculin in animal models of gastric injury and possible machanisms involved.
A Ãlcera pÃptica pode ser definida como sendo uma doenÃa inflamatÃria crÃnica do estÃmago e duodeno, que se apresenta como uma lesÃo na mucosa do trato digestivo, que se estende atravÃs da musculatura da mucosa ou mais profundamente. A Ãlcera pÃptica geralmente ocorre devido a um desequilÃbrio entre os fatores de defesa e agressores da mucosa. Est
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/11/2009
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23. InvestigaÃÃo dos efeitos centrais e gastroprotetores do isopulegol em camundongos / Evaluation of the central nervous system and gastroprotective effects of isopulegol in mice.
Isopulegol is a monoterpene alcohol present in the essential oils of various plants, and has been used in the manufacture of fragrances with blossom compositions. In order to investigate its effects on animal models of CNS actions, isopulegol was administered to male Swiss mice at single doses of 25 and 50 mg/kg 30 (i.p.) or 60 min (p.o.) before the experime
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/08/2009
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24. GASTROPROTECTIVE AND ANTIMICROBIAL ACTIVITIES OF MATRICARIA RECUTITA (CAMOMILA) FLOWER EXTRACT AND ALPHA-BISABOLOL: POSSIBLE MECHANISMS OF ACTION / Potencial farmacolÃgico do extrato seco de matricaria recutita (Chamomilla) e do Alfa-Bisabolol
Matricaria recutita, commonly known as chamomile, is a plant species used in medicine due to its sedative properties, anti-inflammatory and healing, among others. Alpha-bisabolol, a sesquiterpene present in essential oil, also has several pharmacological activities recognized. This work evaluated the gastroprotective activity, antioxidant, antimicrobial and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/08/2009