5 Aminolevulinic Acid
Mostrando 1-12 de 105 artigos, teses e dissertações.
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1. GRAPHEN-PHENYL-NH2 AS NANOCARRIER: A DENSITY FUNCTIONAL THEORY STUDY
Recently, graphene and modified graphene as one of the most suitable and the most important carbon nanomaterials have been introduced for drug delivery. In this paper, we have studied the binding characteristics of the EDC-NHS cross-linking process of graphene-phenyl-NH2 and 5-aminolevulinic acid (ALA) drug in both gas and solvent phases by density functiona
Química Nova. Publicado em: 2022
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2. A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo
Abstract: Background: To study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy. Objective: To assess the clinical efficacy of ALA-PDT for treating vitiligo. Methods: ALA with differ
An. Bras. Dermatol.. Publicado em: 2018-08
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3. Liver Damage Induced by Succinylacetone: A Shared Redox Imbalance Mechanism between Tyrosinemia and Hepatic Porphyrias
To show liver failure mediated by 5-aminolevulinic acid (ALA), a heme precursor accumulated in inborn and acquired porphyrias, rats were treated with succinylacetone methyl ester (SAME). Treated rats underwent the expected ALA accumulation in plasma, liver and urine as a result from inhibition of ALA dehydratase (ALAD) activity. The enzyme activity decreased
J. Braz. Chem. Soc.. Publicado em: 2017-07
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4. Estudo de sistemas nanocarreadores para o ácido 5-aminolevulínico com aplicação na terapia fotodinâmica / Study of nanocarriers systems to 5-aminolevulinic acid for photodynamic therapy use
O ácido 5-aminolevulínico (5-ALA) é empregado como pró-fármaco, precursor de um agente fotossensibilizador na terapia fotodinâmica (TFD). Após a aplicação de 5-ALA topicamente, a incidência de luz visível de comprimento de onda apropriado induz a formação de uma substância altamente fluorescente e fotodinamicamente ativa, a Protoporfirina IX (P
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/05/2012
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5. Detection and clinical outcome of urinary bladder cancer with 5-aminolevulinic acid-induced fluorescence cystoscopy: a multicenter randomized, double-blind, placebo-controlled trial
International braz j urol. Publicado em: 2011-10
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6. Possible in vivo mechanisms involved in photodynamic therapy using tetrapyrrolic macrocycles
Photodynamic therapy (PDT) mediated by oxidative stress causes direct tumor cell damage as well as microvascular injury. To improve this treatment new photosensitizers are being synthesized and tested. We evaluated the effects of PDT with 5,10,15,20-tetrakis(4-methoxyphenyl)-porphyrin (TMPP) and its zinc complex (ZnTMPP) on tumor levels of malondialdehyde (M
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-01
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7. BIOCHEMICAL AND PHYSIOLOGICAL RESPONSES OF Cucumis sativus AND Avena sativa TO EXCESS ALUMINUM STRESS. / RESPOSTAS BIOQUÍMICAS E FISIOLÓGICAS DE Cucumis sativus E Avena sativa AO ESTRESSE CAUSADO POR ALUMÍNIO
Aluminum (Al) is the most abundant metal in the Earth s crust, affecting growth and development of plants. The aim of this study was to investigate the effects of Al on seedlings of cucumber (Cucumis sativus L.) and oat (Avena sativa L) through the analysis of biochemical and physiological parameters. Three different genotypes of oat seedlings were studied,
Publicado em: 2010
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8. D-limonene influence in the cutaneous penetration enhancer for 5-aminolevulinic acid in photodynamic therapy of skin cancer: in vitro and in vivo skin permeation and retention studies. / A influência do D-limoneno como promotor de absorção de ácido 5-aminolevulínico para Terapia Fotodinâmica do câncer de pele: avaliação in vitro e in vivo da permeação e retenção cutâneas
BERTOLINI, WAGNER L. H. M. A influência do D-limoneno como promotor de absorção do ácido 5-aminolevulínico para Terapia Fotodinâmica do câncer de pele: avaliação in vitro e in vivo da permeação e retenção cutâneas. 2009 118f. Tese (Doutorado). Faculdade de Ciências Farmacêuticas de Ribeirão Preto Preto Universidade de São Paulo, Ribeirão P
Publicado em: 2009
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9. Avaliação do estresse oxidativo, genotoxicidade e mutagenicidade em trabalhadores expostos a tintas
Organic solvents and metals, widely used in paints, can lead to DNA damages and reactives species (RS) generation. The aim of this study was to evaluate possibles oxidative, genotoxic and mutagenic damages in 33 male workers exposed for at least six months to paint. To constitute the control group 29 healthy individuals were choosen, without paint exposure,
Publicado em: 2009
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10. Oleic acid influence as a cutaneous penetration enhancer for 5- aminolevulinic acid photodynamic therapy of skin cancer: in vitro and in vivo studies in animal model. / Influência do ácido oléico como promotor de absorção cutânea para o ácido 5-aminolevulínico na terapia fotodinâmica do câncer de pele: estudos in vitro e in vivo em modelo animal
The topical administration of 5-ALA has been distinguished on skin cancer photodynamic therapy (PDT) because of its efficiency in the treatment of tumors and the reduced phototoxic collateral effects. However, this effectiveness is limited by its low penetration in the skin. A proposal to optimize the 5-ALA penetration in the skin is the use of cutaneous pen
Publicado em: 2007
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11. Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5-delta-aminolevulínico tópíco: avaliação imunoistoquímica, do colágeno e do tecido elástico / Study of photo aged human skin after photodynamic therapy treatment with topic 5 delta aminolevulinic acid: immunohistochemical, colagenous and elastic fibre analysis.
PDT is nowadays considered one of the therapies for photo-aging, since it gives a satisfactory response for both, aesthetic result as well as treating and preventing pre-malignous lesions that are a frequent outcome of photo-aged skin. The selective destruction of target tissue occurs through a chemical reaction, by using a photosensitizing agent exposed to
Publicado em: 2007
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12. Efeitos do chumbo sobre a atividade da tioredoxina redutase citosólica (TrxR1) e parâmetros de estresse oxidativo em rins de ratos. / Effects of lead acetate exposure on renal cytosolic thioredoxin reductase (TrxR1) activity and on indicators of lead exposure.
Lead is a heavy metal that accumulates primarily in kidney, where exerts its nephrotoxic effects. Several studies suggest that the oxidative stress is an important molecular mechanism for the toxic effects of lead in kidney and in other organs. Cytosolic thioredoxin reductase (TrxR1) is a selenoflavoprotein involved in many processes modulating intracellular
Publicado em: 2007