4977bp Deletion
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Mitochondrial DNA common deletion is not associated with thyroid, breast and colorectal tumors in Turkish patients
Recently, efforts have been focused on mitochondrial DNA changes and their relation to human cancers. Among them, a 4977 bp deletion of mitochondrial DNA, named "common deletion", has been investigated in several types of tumors, with inconsistent results. In this study, we investigated the presence of the common deletion in tissues from 25 breast, 25 colore
Genetics and Molecular Biology. Publicado em: 18/12/2009
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2. Prevalência da deleção 4977pb do DNA mitocondrial em pacientes com doença renal crônica em tratamento conservador ou submetidos a hemodiálise no sul do Brasil / Prevalence of 4977bp deletion in mitochondrial DNA from patients with chronic renal disease receiving conservative treatment or hemodialysis in southern Brazil
Introdução. Danos no DNA mitocondrial (DNAmt) têm sido descritos em pacientes com doença renal crônica (DRC). Estes danos podem ser avaliados através da deleção 4977pb do DNAmt em diversos tecidos. Métodos. Identificamos a prevalência da deleção 4977pb do DNAmt através da técnica da reação em cadeia da polimerase (PCR) no sangue de pacientes
Publicado em: 2007
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3. Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing.
In 60 human tissue samples (encompassing skeletal muscle, heart and kidney) obtained from subjects aged from under 1 to 90 years, we used quantitative PCR procedures to quantify mitochondrial DNA (mtDNA) molecules carrying the 4977 bp deletion (mtDNA4977) and 3243 A-->G base substitution. In addition, the prevalence of multiple mtDNA deletions was assessed i
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4. Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide
Human diploid fibroblasts (HDFs) exposed to subcytotoxic stresses under H2O2, tert-butylhydroperoxide (t-BHP), and ethanol (EtOH) undergo stress-induced premature senescence (SIPS) characterized by many biomarkers of HDFs replicative senescence. Among these biomarkers are a growth arrest, an increase in the senescence-associated β-galactosidase activity, a
Cell Stress Society International.