4 Chagas Disease
Mostrando 13-24 de 271 artigos, teses e dissertações.
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13. Fatores associados à hipotensão ortostática em adultos: estudo ELSA-Brasil
Resumo: O objetivo foi investigar os fatores associados à presença de hipotensão ortostática em 14.833 indivíduos de 35-74 anos. Estudo transversal realizado com os dados da linha de base (2008-2010) do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). O teste postural foi realizado após repouso de 20 minutos na posição supina e adoção ativa d
Cad. Saúde Pública. Publicado em: 12/08/2019
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14. Design, Synthesis, Trypanocidal Activity, and Studies on Human Album in Interaction of Novel S-Alkyl-1,2,4-triazoles
Chagas disease is a neglected tropical disease caused by the hemoflagellated parasite Trypanosoma cruzi (Kinetoplastida). The only available drug to treat chagasic patients in Brazil, the nitroheterocycle benznidazole, is effective solely during the acute phase of the infection. There is accordingly a need to develop new therapeutic tools for the treatment o
J. Braz. Chem. Soc.. Publicado em: 04/07/2019
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15. In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents
BACKGROUND Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10) analogs of megazol (3). OBJECTIVES To evaluate whether the genotoxic effect of 3 was abolished in the
Mem. Inst. Oswaldo Cruz. Publicado em: 27/06/2019
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16. Manifestações e estratégias de enfrentamento da Doença de Chagas que interferem na qualidade de vida do indivíduo: uma revisão sistemática
Resumo Objetivou-se identificar as manifestações e as estratégias de enfrentamento da doença de Chagas que impactam na qualidade de vida do sujeito acometido. Trata-se de estudo de revisão sistemática de literatura, realizada nas bases de dados PubMed, SciELO e Lilacs, através das quais se reuniu um quantitativo de 6 artigos, além de 6 publicações
Ciênc. saúde coletiva. Publicado em: 02/05/2019
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17. Association between Chagas disease and changes in the optic nerve and retinal nerve fiber layer
RESUMO Objetivo: Testar a hipótese de que a doença de Chagas predispõe a alterações no nervo óptico e camada de fibras nervosas peripapilar. Métodos: Foi realizado um estudo transversal com 41 pacientes diagnosticados com doença de Chagas e 41 controles, pareados por sexo e idade. Os pacientes foram submetidos a exames oftalmológicos, incluindo me
Arq. Bras. Oftalmol.. Publicado em: 21/02/2019
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18. Lack of evidence of seronegative infection in an endemic area of Chagas disease
ABSTRACT The diagnosis of Chagas disease is based on the detection of Trypanosoma cruzi (T. cruzi)-specific antibodies. Nonetheless, there is concern about the sensitivity of current serological assays due to reports of T. cruzi PCR positivity among seronegative individuals. The aim of this study was to evaluate if T. cruzi seronegative infections occur in e
Rev. Inst. Med. trop. S. Paulo. Publicado em: 14/02/2019
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19. Cardiac Evaluation in the Acute Phase of Chagas’ Disease with Post-Treatment Evolution in Patients Attended in the State of Amazonas, Brazil
Resumo Fundamento: Nas últimas duas décadas, um novo perfil epidemiológico da Doença de Chagas (DC) foi registrado na Amazônia brasileira, onde a transmissão oral foi indicada como responsável pelo aumento dos casos agudos. No estado do Amazonas, foram registrados cinco surtos da doença desde 2004. As manifestações cardíacas nesses casos podem se
Arq. Bras. Cardiol.. Publicado em: 07/01/2019
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20. Epidemiological and clinical profile of HIV-infected patients from Southwestern Goias State, Brazil
ABSTRACT Knowledge about epidemiological distribution patterns of HIV infection in different geographic regions is relevant to understand the dynamics of the disease in Brazil. This study aims to characterize the epidemiological and clinical profile of HIV-infected patients from Southwestern Goias State, from 2005 to 2015. A standardized questionnaire was us
Rev. Inst. Med. trop. S. Paulo. Publicado em: 19/07/2018
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21. Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
BACKGROUND The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 s
Mem. Inst. Oswaldo Cruz. Publicado em: 14/05/2018
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22. Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment
BACKGROUND The current chemotherapy for Chagas disease is based on monopharmacology with low efficacy and drug tolerance. Polypharmacology is one of the strategies to overcome these limitations. OBJECTIVES Study the anti-Trypanosoma cruzi activity of associations of benznidazole (Bnz) with three new synthetic T. cruzi-triosephosphate isomerase inhibitors,
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-03
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23. Chronic Chagas Cardiomyopathy Patients and Resynchronization Therapy: a Survival Analysis
Abstract Introduction: Chagas disease represents an important health problem with socioeconomic impacts in many Latin-American countries. It is estimated that 20% to 30% of the people infected by Trypanosoma cruzi will develop chronic Chagas cardiomyopathy (CCC), which is generally accompanied by heart failure (HF). Cardiac resynchronization therapy (CRT) m
Braz. J. Cardiovasc. Surg.. Publicado em: 2018-02
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24. Evaluation of in vitro anti-Trypanosoma cruzi activity of medications benznidazole, amiodarone hydrochloride, and their combination
Abstract INTRODUCTION: Approximately seven to eight million people worldwide have Chagas disease. In Brazil, benznidazole is the most commonly used active drug against Trypanosoma cruzi; however, its efficacy is limited, and side effects are frequent. Recent studies suggest that amiodarone may be beneficial in the treatment of this disease, by exerting anti
Rev. Soc. Bras. Med. Trop.. Publicado em: 2018-02