2 Pyridineformamide Thiosemicarbazones
Mostrando 1-3 de 3 artigos, teses e dissertações.
-
1. Cytotoxicity and Leishmanicidal Activity of Isoniazid-Derived Hydrazones and 2-Pyrazineformamide Thiosemicarbazones
The isoniazid-derived hydrazones 2-pyridinecarbaldehyde- (HPCIH), 2-acetylpyridine- (HAPIH), 2-benzoylpyridine- (HBPIH), 2-pyridineformamide- (HPAmIH) and 2-pyrazineformamide- (HPzAmIH) isonicotinoyl hydrazones, as well as the pyrazinamide-derived thiosemicarbazones 2-pyrazineformamide- (HPzAm4DH), N(4)-methyl-2-pyrazineformamide- (HPzAm4M), N(4)-ethyl-2-pyr
J. Braz. Chem. Soc.. Publicado em: 2016-04
-
2. COMPLEXOS METÁLICOS DE 2-PIRIDINOFORMAMIDA TIOSSEMICARBAZONAS: ESTUDOS EM SOLUÇÃO, NO ESTADO SÓLIDO E ATIVIDADE CITOTÓXICA / METAL COMPLEXES OF 2-PYRIDINEFORMAMIDE THIOSEMICARBAZONES: SOLUTION STUDIES, SOLID STATE STUDIES AND CYTOTOXIC ACTIVITY.
Thiosemicarbazones and their metal complexes present a wide range of bioactivities. It has been shown that the antitumoral action of á(N)-heterocyclic thiosemicarbazones occurs through the inhibition of ribonucleotide diphosphate reductase (RDR), a key enzyme involved in the conversion of ribonucleotides into deoxyribonucleotides during DNA syntheses. The a
Publicado em: 2008
-
3. Caracterização da atividade antitumoral das tiossemicarbazonas derivadas de N(4)-Metil-Toluil-2-acetilpiridina e de 2-piridinoformamida e seus complexos metálicos: avaliação do potencial radiofarmaceutico / CHARACTERIZATION OF THE ANTITUMURAL ACTIVITY OF THE THIOSEMICARBAZONES DERIVED FROM N(4)-METHYL-TOLYL-2- ACETYLPYRIDINE AND 2-PIRIDINOFORMAMIDE AND ITS METAL COMPLEX: EVALUATION OF THE RADIOPHARMACEUTICAL POTENTIAL.
Thiosemicarbazones have attracted great pharmacological interest because of their biological properties, such as cytotoxic activity against multiple strains of human tumors. The most studied compounds are pyridine-based because of their resemblance to pyridoxal metabolites that attach to co-enzyme B6-dependant enzymes. This work aimed the characterization of
Publicado em: 2008