2 Inkt Cells
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Imunopatologia da dengue: receptores de quimiocinas CC e células iNKT
Dengue virus (DENV), a mosquito-borne flavivirus, is a serious public health problem in many tropical countries. Immune mechanisms involved in the pathogenesis of DENV infection are not fully elucidated. Recent clinical data showed an association between levels of different CC chemokines in plasma and severity of dengue. In this regard, we evaluated the role
Publicado em: 2010
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2. Identificação de iGb3 e iGb4 em células de melanoma murino B16F10- Nex2 e efeito antitumoral de células dendríticas primadas com iGb3 mediado por células iNKT. / Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3
Células iNKT restritas a CD1d são protetoras contra o desenvolvimento de melanoma murino, B16F10-Nex2, subcutaneamente em animais singênicos. Essa proteção pode ser deduzida pelo desenvolvimento acelerado do tumor em animais geneticamente deficientes na expressão de CD1d (CD1d-KO), com sobrevida significantemente menor do que a observada com animais WT
Publicado em: 2009
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3. Transcriptional regulator Id2 controls survival of hepatic NKT cells
Natural killer T cells expressing an invariant T-cell receptor (iNKT) regulate activation of both innate and adaptive immunity in many contexts. iNKT cells accumulate in the liver and rapidly produce prodigious amounts of numerous cytokines upon activation, impacting the immune response to viral infection, immunosurveillance for malignant cells, and liver re
National Academy of Sciences.
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4. Rapid and reliable generation of invariant natural killer T-cell lines in vitro
Several tools have proved useful in the study of invariant natural killer T (iNKT) cells, including CD1d-deficient mice, Jα281-deficient mice, synthetic lipid antigens and antigen-loaded CD1d tetramers. However, the generation and examination of long-term primary murine iNKT cell lines in vitro has been challenging. Here, we show the rapid generation of iNK
Blackwell Science Inc.
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5. CD1d and invariant NKT cells at the human maternal–fetal interface
Invariant CD1d-restricted natural killer T (iNKT) cells comprise a small, but significant, immunoregulatory T cell subset. Here, the presence of these cells and their CD1d ligand at the human maternal–fetal interface was investigated. Immunohistochemical staining of human decidua revealed the expression of CD1d on both villous and extravillous trophoblasts
The National Academy of Sciences.
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6. Severe loss of invariant NKT cells exhibiting anti–HTLV-1 activity in patients with HTLV-1–associated disorders
Invariant natural killer T (iNKT) cells are unique T cells that regulate the immune response to microbes, cancers, and autoimmunity. We assessed the characteristics of iNKT cells from persons infected with human T-lymphotropic virus type 1 (HTLV-1). Whereas most infected persons remain asymptomatic carriers (ACs) throughout their lives, a small proportion, u
American Society of Hematology.
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7. Invariant Natural Killer T Cells and TGF-β Attenuate Anti-GBM Glomerulonephritis
Invariant natural killer T (iNKT) cells represent a particular subset of T lymphocytes capable of producing several cytokines, which exert regulatory or effector functions, following stimulation of the T cell receptor. In this study, we investigated the influence of iNKT cells on the development of experimental anti-glomerular basement membrane glomeruloneph
American Society of Nephrology.
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8. Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell–mediated immunotherapy
Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration of the glycolipid ligand α-galactosylceramide (α-GalCer) or the sphingosine-truncated α-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and γ interferons that contribute to DC maturation. This process enhanc
American Society for Clinical Investigation.
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9. Disruption of T helper 2-immune responses in Epstein–Barr virus-induced gene 3-deficient mice
Epstein–Barr virus-induced gene 3 (EBI3) is a widely expressed IL-12p40-related protein that associates as a heterodimer with either IL-12p35 or an IL-12p35 homologue, p28, to create a new cytokine (IL-27). To define the function of EBI3 in vivo, we generated knockout mice in which the ebi3 gene was targeted by homologous recombination. EBI3−/− mice ex
National Academy of Sciences.
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10. Invariant natural killer T cell–natural killer cell interactions dictate transplantation outcome after α-galactosylceramide administration
Invariant natural killer T cells (iNKT cells) have pivotal roles in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects. iNKT cells are activated through their T-cell receptors by glycolipid moieties (typically the α-galactosylceramide [α-GalCer] derivative KRN7000) presented within CD1d. We investigated the ability of modified α-GalC
American Society of Hematology.