17 Alpha Hydroxyprogesterone
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin
ABSTRACT Objective The aim of this study was to investigate polycystic ovary syndrome (PCOS) and to explore the relationship between body fat percentage and metabolic markers. Subjects and methods Sedentary women were assigned to PCOS (N = 60) and CONTROL (N = 60) groups. Each group was subdivided into three subgroups according to body fat percentage (22
Arch. Endocrinol. Metab.. Publicado em: 2020-02
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2. Evidências de desregulação endócrina causada pela exposição aquática ao alumínio e ao manganês em Astyanax bimaculatus (Linnaeus, 1758) / Evidences of endocrine disruption caused by aquatic exposure to aluminum and manganese in Astyanax bimaculatus (Linnaeus, 1758)
Metals such as Aluminum (Al) and Manganese (Mn) are found in nature as well as in industrial effluents, and can be toxic to aquatic biota, with endocrine disrupting effects, e.g. for fish, which can affect the reproductive performance of a species. Rivers and tributaries of São Paulo State, even in theoretically preserved areas, have shown an increase in th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/09/2012
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3. Avaliação metabólica de mulheres jovens com hiperplasia adrenal congênita / Metabolic evaluation in young women with congenital adrenal hyperplasia
Introdução: Pacientes adultos com hiperplasia adrenal congênita (HAC) por deficiência de 21-hidroxilase apresentam maior incidência de obesidade, adiposidade visceral, hiperinsulinismo, resistência insulínica e hiperandrogenismo que indivíduos normais. A disfunção adrenomedular e o hipercortisolismo intermitente parecem estar associados a estas ano
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2011
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4. Phenotype and genotype correlation of the microconversion from the CYP21A1P to the CYP21A2 gene in congenital adrenal hyperplasia
Deficiency of 21-hydroxylase is the most common form of congenital adrenal hyperplasia (CAH-21OH). We determined by allele-specific PCR the frequency of microconversion in the CYP21A2 gene in 50 Brazilian patients with the classical (salt wasting: SW and simple virilizing: SV) forms and nonclassical (NC) form of CAH-21OH and correlated genotype with phenotyp
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-10
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5. Functional effects of 17alpha-hydroxyprogesterone caproate (17P) on human myometrial contractility in vitro
BioMed Central.
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6. Effect of estrogens on the myeloperoxidase-mediated antimicrobial system.
Estradiol 17 beta prevented the fall in the microbicidal activity of the myeloperoxidase-H2O2-halide system induced by high H2O2 concentrations. In contrast, when the H2O2 (and halide) concentrations were low the myeloperoxidase-H2O2-halide antimicrobial system was inhibited by estradiol. These properties of estradiol 17 beta were shared by estradiol 17 alph
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7. Localization of 17beta-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frog.
Several enzymes involved in the formation of steroids of the pregnene and pregnane series have been identified in the brain, but the biosynthesis of testosterone has never been reported in the central nervous system. In the present study, we have investigated the distribution and bioactivity of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) (EC 1.1.1.62; a
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8. Abnormal steroid excretion in gestational trophoblastic disease complicated by ovarian theca-lutein cysts.
Serum and urine steroids were examined in two subjects with trophoblastic disease accompanied by large ovarian theca-lutein cysts and compared with those from 10 patients with trophoblastic disease but without palpable cysts. In the patients without cysts normal values were obtained for serum oestradiol, progesterone, 17 alpha-hydroxyprogesterone and androst
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9. Characterization of the steroid-metabolizing capacity of the hepatic cytochrome P450IIC5 expressed in COS-1 cells: 3 beta-hydroxysteroid dehydrogenase/delta 5----4 isomerase type activity.
Cytochrome P450IIC5 (rabbit liver 21-hydroxylase) is unusual among hepatic forms of cytochromes P450 because it catalyzes the conversion of one active steroid hormone (progesterone) to another active hormone (deoxycorticosterone). Another interesting aspect of this steroid-hydroxylating enzyme is the ability to convert delta 5-3 beta-hydroxysteroids to the d
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10. cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.
Mouse MA-10 Leydig tumor cells synthesize and secrete progesterone in response to human chorionic gonadotropin, luteinizing hormone, and cAMP but may not synthesize androgens. Maximal doses of human chorionic gonadotropin, ovine luteinizing hormone, forskolin, or 8-bromoadenosine 3',5'-cyclic monophosphate, stimulated cytochrome P450scc mRNA accumulation 1.5
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11. Disappearance and unexpected reappearance of progesterone in the circulation of the monkey: novel hormone kinetics.
1. Intravenous injection of [3H]progesterone in non-pregnant monkeys resulted in total disappearance of the labelled hormone from the circulation within 3 h. However, 0.5-1.75 h after disappearance the hormone reappeared, reaching 20% (median, 5%) of the initial maximal concentration. 2. Reappearance of labelled hormone was accompanied by similar fluctuation
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12. Assessment of the one hour adrenocorticotrophic hormone test in the diagnosis of attenuated 21-hydroxylase deficiency.
Attenuated or partial 21-hydroxylase deficiency is one of several biochemical defects in steroid metabolism that can lead to hirsutism in young women after puberty. The diagnosis is made through the exaggerated response of 17 alpha-hydroxyprogesterone (17-OH) to adrenocorticotrophic hormone (ACTH). To provide reference data 72 mild to moderately hirsute pati