1 Genotoxic Stress
Mostrando 1-12 de 79 artigos, teses e dissertações.
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1. Caracterização do gene LmHUS1 e de sua participação no fenômeno de amplificação gênica em Leishmania spp. / LmHUS1 gene characterization and its participation in the gene amplification in Leishmania spp.
The protozoan parasite Leishmania presents a dynamic and plastic genome in which gene amplification and chromosome translocations are common phenomena. Such plasticity hints at the necessity of dependable genome maintenance pathways. Eukaryotic cells have evolved checkpoint control systems that recognize altered DNA structures and halt cell cycle progression
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
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2. Análise de Marcadores Gênicos de Estresse Genotóxico em Fibroblastos Humanos Normais e Células de Glioblastoma. / Analysis of Gene Markers of Genotoxic Stress in Human Normal Fibroblasts and Glioblastoma Cells.
Muitos genes têm sido indicados como responsivos ao estresse genotóxico, mas devido à necessidade de validação, a busca por marcadores gênicos continua. Vários genes são relacionados ao sistema ubiquitina-proteassomo (UPS), o qual é responsável pela remoção seletiva de proteínas, sendo que falhas no UPS têm sido relacionadas a doenças neurodeg
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/08/2011
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3. Atividade antioxidante e hepatoprotetora de plantas brasileiras, contendo compostos fenólicos.
Plants from Brazilian flora were chosen and studied for their in vitro and in vivo antioxidant and in vivo hepatoprotetive activity, especially in relation to phenolic compounds which have several health benefits. These plants include Phyllanthus niruri, Solanum fastigiatum, Solidago microglossa and Baccharis trimera. The aqueous extracts of leaves showed in
Publicado em: 2010
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4. Study of the effects of naphthalene and benzo(a) pyrene in Trachinotus carolinus (Perciformes, Carangidae) using citogenotoxic, histopahological and biochemical biomarkers. / Estudo sobre efeitos do naftaleno e benzo(a) pireno em Trachinotus carolinus (Perciformes, Carangidae) utilizando biomarcadores citogenotóxicos, histopatológicos e bioquímicos
Effects of exposure of fish to pollutants can be identified through stress responses. The present study aims to evaluate the effects of naphthalene and benzo(a)pyrene in Florida pompanos, Trachinotus carolinus. Evidences from citogenotoxical, histopathological and biochemical studies showed that alterations caused by exposures to 0.9 M, 2.7 M and 8.1 M of NA
Publicado em: 2009
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5. Investigação das atividades mutagênica, antimutagênica e antioxidante de extratos etanólicos de Aiouea trinervis, Nectandra cissiflora, Ocotea minarum (Lauraceae) e dos alcalóides triptofol, ocoteína e dicentrina
The Brazilian cerrado (tropical American savanna) is a semi-arid region in which plants are submitted to metabolic stress that triggers defense mechanisms when confronted with unfavorable environmental conditions. The Lauraceae is an economically important family with 52 genera and approximately 2500-2750 species consisting mostly of trees or tree-like shrub
Publicado em: 2008
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6. Estudo da relaÃÃo entre a atividade anti-tumoral in vitro do Ãcido Ãsnico e a ativaÃÃo da via metabÃlica p53
Usnic acid is a metabolite of lichen that exerts a wide variety of biological activities including cytotoxicity against cells derived from human malignant tumours. Although cytotoxicity of usnic acid has been extensively reviewed, its mechanism of action is still unclear. There are no data in the literature about the involvement of the tumour suppressor p53
Publicado em: 2006
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7. Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis
Genotoxic stress activates complex cellular responses allowing for the repair of DNA damage and proper cell recovery. Although plants are exposed constantly to increasing solar UV irradiation, the signaling cascades activated by genotoxic environments are largely unknown. We have identified an Arabidopsis mutant (mkp1) hypersensitive to genotoxic stress trea
Cold Spring Harbor Laboratory Press.
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8. YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress
The tumor suppressor p53 regulates cell-cycle progression and apoptosis in response to genotoxic stress, and inactivation of p53 is a common feature of cancer cells. The levels and activity of p53 are tightly regulated by posttranslational modifications, including phosphorylation, ubiquitination, and acetylation. Here, we demonstrate that the transcription f
National Academy of Sciences.
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9. p53 Regulation of G2 Checkpoint Is Retinoblastoma Protein Dependent
In the present study, we investigated the role of p53 in G2 checkpoint function by determining the mechanism by which p53 prevents premature exit from G2 arrest after genotoxic stress. Using three cell model systems, each isogenic, we showed that either ectopic or endogenous p53 sustained a G2 arrest activated by ionizing radiation or adriamycin. The mechani
American Society for Microbiology.
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10. Activation of MEK Kinase 1 by the c-Abl Protein Tyrosine Kinase in Response to DNA Damage
The c-Abl protein tyrosine kinase is activated by certain DNA-damaging agents and regulates induction of the stress-activated c-Jun N-terminal protein kinase (SAPK). Here we show that nuclear c-Abl associates with MEK kinase 1 (MEKK-1), an upstream effector of the SEK1→SAPK pathway, in the response of cells to genotoxic stress. The results demonstrate that
American Society for Microbiology.
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11. Role for Lyn Tyrosine Kinase as a Regulator of Stress-Activated Protein Kinase Activity in Response to DNA Damage
The cellular response to DNA damage includes activation of the nuclear Lyn protein tyrosine kinase. Using cells deficient in Lyn expression, the present studies demonstrate that Lyn is required in part for induction of the stress-activated protein kinase (SAPK) in the response to 1-β-d-arabinofuranosylcytosine (ara-C) and other genotoxic agents. By contrast
American Society for Microbiology.
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12. Distinct regulation of salinity and genotoxic stress responses by Arabidopsis MAP kinase phosphatase 1
The Arabidopsis genome contains 20 genes encoding mitogen-activated protein kinases (MAPKs), which drastically outnumbers genes for their negative regulators, MAP kinase phosphatases (MKPs) (five at most). This contrasts sharply with genomes of other eukaryotes where the number of MAPKs and MKPs is approximately equal. MKPs may therefore play an important ro
Oxford University Press.