Tripanocidal Activity
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Sintese e atividade biologica de analogos furanicos da goniotalamina / Synthesis and biological activity of furan analogues of goniothalamin
This work describes the preparation of furan analogues of goniothalamin (compounds 31, 32 and 33) in both enantiomeric forms through the utilization of Keck asymmetric allylation and ring-closing methatesis reaction. These analogues were prepared in good overall yield and excellent enantiomeric ratio. These novel compounds were evaluated as antiproliferative
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/07/2009
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2. Caracterização funcional e estrutural de uma L-Aminoácido oxidace do veneno de Bothrops jararacussue avaliação da sua ação antitumoral, antiparasitária e bactericida / Functional and structural characterization of an L-aminoacid oxidace from Bothrops jararacussuvenom and the evaluation of its antitumoral, antiparasitic and bactericidal action
In this research we described the isolation and biochemical, structural and functional characterization of an L-amino acid oxidase from Bothrops jararacussu venom, named BjussuLAAO. The purification was carried out through three chromatography steps, using a molecular filtration on Sephadex G-75, followed by an affinity chromatography on Benzamidine-Sepharos
Publicado em: 2006
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3. "Estudo químico e atividades biológicas de extratos obtidos de culturas de Penicillium verrucosum Dierck" / Chemical study and biological activities of crude extracts obtained from different cultures of Penicillium verrucosum Dierck
The absence of an effective treatment for Chagas disease and Leishmaniasis stimulates the search for new active compounds. The enzymes GAPDH from T. cruzi and APRT from L. tarentolae are attractive targets for rational search of antiprotozoal agents, taking part in essential pathways of the pathogens. Natural products are rich in structural diversity and b
Publicado em: 2003
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4. Avaliação "in vitro" e "in vivo" da atividade biologica dos derivados da n-aminometilftalimida sobre Trypanosoma cruzi
The search for new compounds capable to kill Trypanosoma cruzi, the etiologic agent of Chagas disease, been an interesting subject for researches. According to the literature, phthalimide compounds have showed good results against this parasite. The present study was carried out to estimate tripanocidal activity of seven N aminometylphthalimide compounds in
Publicado em: 2002