Reproductive Toxicology
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through severa
Braz J Med Biol Res. Publicado em: 12/12/2016
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2. Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats
Copaiba oil, extracted from Copaifera multijuga Hayne, Fabaceae, is widely used for medicinal purposes, especially to treat inflammatory processes. However, there is no report regarding its effect on reproductive performance after used in repeated doses orally. The present study evaluated the effects of the oral administration of Copaiba oil (at doses of 200
Rev. bras. farmacogn.. Publicado em: 2014-06
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3. Efeitos do inseticida endossulfam sobre a morfologia e a morfometria testicular em morcegos frugívoros Artibeus lituratus (OLFERS, 1818) / Effects of the endosulfan on the testicular morphology and morphometry in fruit bats Artibeus lituratus (OLFERS, 1818)
Large amounts of agricultural chemicals are discharged into the environment in Brazil. These pesticides are often used to destroy or impair the activity of organisms that attack crops. There are some reports in the literature concerning the decline of many wildlife populations as a result of contamination of their habitats by pesticides. One of the putative
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2012
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4. Avaliação da toxicidade da Ipomoea carnea em caprinos durante o período perinatal: estudos de neuroteratologia / Evaluation of the toxicity of Ipomoea carnea in goats during postnatal period
Ipomoea carnea, a shrub plant, is a toxic plant largely distributed throughout Brazil and others topical countries. This plant possess swainsonine, an indolizidinic alkaloid as the most important active toxic principle, which promotes cellular accumulation of not metabolized oligossacarides, due to inhibition of acid or lisossomal αmanosidasis enzyme,
Publicado em: 2009
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5. AvaliaÃÃo toxicolÃgica reprodutiva do fitoterÃpico sanativoÂ
The effects of the administration of Sanativo (SAN) were investigated on the pregnancy in Wistar rats. Four groups of female rats (5-8/group) were treated orally with SAN (67, 335 and 1675mg/kg) or water during the pregnancy period (1st to the 21st day) and during each one of the two first phases of pregnancy: pre-implantation (1st to the 6th day) and orga
Publicado em: 2007
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6. AvaliaÃÃo toxicolÃgica prÃ-clÃnica do Ãleo de Carapa guianensis Aublet.
Carapa guianensis (Meliaceae), a typical tree from amazon region, is popularly known as Andiroba. Its seed oil is used as anti-inflammatory, analgesic and insect repellent. Although C. guianensis is largely used by people, there are no studies concerning its toxicity. In this way, the aim of this work was to evaluate the safety of the C. guianensis seed oil
Publicado em: 2006
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7. Desenvolvimento reprodutivo de ratos machos expostos ao fenvalerato in utero e lactação / Reproductive development of male rats exposed to fenvalerate in utero and lactation
Fenvalerate is a synthetic pyrethroid insecticide used in agriculture, cattle raising and in the control of domestic insects, and its reproductive effects are little-known.Some studies already have proposed that fenvalerate is an endocrine disruptor, acting as an environmentalestrogen. Studies done with rats exposed to some pyrethroids showed reduction of sp
Publicado em: 2005
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8. Efeitos na esfera reprodutiva da exposição prolongada a Solanum lycocarpum durante a puberdade de ratos / Effects on reproductive system of long-term exposition to Solanum lycocarpum during rats puberty
Solanum lycocarpum St. Hil, a toxic plant common in almost all states of Brazil, may be consumed by animals in fertile age and in natural condition. The fruits of this plant contain steroidal glycoalkaloids with steroid-like properties. Presently the reproductive effects of S. lycocarpum fruit ingestion during puberty were investigated. The dried fruits were
Publicado em: 2005
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9. Reproductive toxicity of diuron in adult male rats / Toxicidade reprodutiva do diuron em ratos machos adultos
O diuron (3-(3,4-diclorofenil)- Ll-dimetilurea) é um herbicida uréico cuja DL:io oral aguda em ratos é igual a 3400 mg/Kg. É muito utilizado na agricultura e seus efeitos no organismo animal ainda são pouco conhecidos. principalmente no sistema reprodutor. O objetivo dcste trabalho foi avaliar o possível efeito tóxico do diuron no sistema reprodutor m
Publicado em: 2005
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10. Solanum lycocarpum St. Hil unripe fruit effects in pregnant rats and offspring: alterations in reproductive and central monoaminergic systems / Efeitos dos frutos da Solanum lycocarpum St. Hil. em ratas prenhes e sua prole durante a gestação e início da lactação: alterações na esfera reprodutiva e na atividade dos sistemas monoaminérgicos centrais
A Solanum lycocarpum St. Hil (Solanaceae) é uma planta nativa do cerrado brasileiro, cujos frutos possuem os glicoalcalóides esteroidais solasonina e solamargina. É possível que a ingestão de frutos que contenham esses glicoalcalóides possam interferir no equilíbrio do sistema endócrino. O presente estudo foi realizado com o objetivo de avaliar os po
Publicado em: 2005
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11. Toxidade reprodutiva do diuron em ratos machos adultos / Reproductive toxicity of diuron in adult male rats
O diuron (3-(3,4-diclorofenil)-1,1-dimetilurea) é um herbicida uréico cuja DL50 oral aguda em raios é igual a 3400 mg/Kg. É muito utilizado na agricultura e seus efeitos no organismo animal ainda são pouco conhecidos, principalmente no sistema reprodutor. O objetivo deste trabalho foi avaliar o possível efeito tóxico do diuron no sistema reprodutor ma
Publicado em: 2005
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12. AvaliaÃÃo toxicolÃgica prÃ-clÃnica do extrato hidroalcoÃlico de Calendula officinalis L.
O efeito do extrato hidroalcoÃlico (EHA) de Calendula officinalis L., Asteraceae, foi investigado sobre a performance reprodutiva de ratos. Quatro grupos de ratos (n=9/grupo) foram tratados durante 60 dias consecutivos por via oral com extrato hidroalcoÃlico de C. officinalis nas doses de 0,25; 0,5 e 1,0g/kg e Ãgua destilada (grupo controle). Foram avalia
Publicado em: 2004