Reproductive Toxicity
Mostrando 1-12 de 63 artigos, teses e dissertações.
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1. Reproductive toxicity of neem seeds (Azadirachta indica) in male quail (Coturnix coturnix japonica)
RESUMO: Considerando que o neem (Azadirachta indica A. Juss.) causa efeitos deletérios na fertilidade, objetivou-se avaliar o efeito da alimentação com sementes de neem sobre a qualidade seminal, parâmetros biométricos e morfometria testicular com codornas (Coturnix coturnix japonica Linnaeus, 1758) com 90 dias de idade, como modelo experimental. Após
Cienc. Rural. Publicado em: 14/11/2019
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2. Protective Effect of Rosa Canina Extract Against Doxorubicin-induced Testicular Toxicity in Mice
Abstract The present study was aimed to investigate the in vivo effects of Rosa canina extract on doxorubicin-induced testicular toxicity in mice for the first time. Male NMRI mice were randomly divided into six treatment groups (10=per group) as follows: (I) vehicles, (II) doxorubicin alone (3 mg/kg, i.p. on days 7, 14 and 21), (III and IV): Rosa canina ext
Braz. arch. biol. technol.. Publicado em: 13/06/2019
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3. Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter Equigan in rat testes
ABSTRACT Equigan is an anabolic steroid that has been developed for veterinary use and derived from endogenous sex hormone testosterone that plays a key role in the development of male reproductive tissue as well as in puberty and spermatogenesis. The current study is aimed to investigate the possible prophylactic effect of star anise extracts (SAE) on the t
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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4. Low-protein diet does not alter reproductive, biochemical, and hematological parameters in pregnant Wistar rats
The aim of this study was to investigate the reproductive, biochemical, and hematological outcomes of pregnant rats exposed to protein restriction. Wistar rat dams were fed a control normal-protein (NP, 17% protein, n=8) or a low-protein (LP, 8% protein, n=14) diet from the 1st to the 20th day of pregnancy. On the 20th day, the clinical signs of toxicity wer
Braz J Med Biol Res. Publicado em: 21/05/2018
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5. Oxidative stress and histopathologic biomarkers of exposure to bisphenol-A in the freshwater fish, Ctenopharyngodon idella
ABSTRACT Bisphenol-A (BPA) belongs to the family of endocrine disrupting chemicals (EDCs) and it is used in the production of polycarbonate plastic and epoxy resins. The reproductive toxicity of BPA is well documented but it also exerts its toxic effects through multiple pathways especially by inducing a state of oxidative stress and causing damage to the vi
Braz. J. Pharm. Sci.. Publicado em: 01/02/2018
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6. Aggravation of cyclophosphamide-induced reproductive toxicity in mice by aqueous extract of Aegle marmelos (L.)
ABSTRACT Aegle marmelos (L.) (Rutaceae) commonly known as bael is an important medicinal fruit tree. The present study focused on the effects of aqueous extract of Aegle marmelos (AEAM) on the testis and sperm characteristics induced by cyclophosphamide (CPA) in mice. Thirty six adult Parke’s strain mice were divided into six groups: group I given only dis
Braz. J. Pharm. Sci.. Publicado em: 26/10/2017
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7. Actividad de enzimas del estrés oxidativo en plantas de tomate cv. Amalia en respuesta al plomo
ABSTRACT Contamination of soils by heavy metals is a result of human activity, agriculture and industry. Among heavy metals, lead is a potential pollutant that in plants causes numerous symptoms of toxicity such as stunted growth, blackening of the root system and generalized chlorosis. The activity of superoxide dismutase enzyme (SOD; EC 1.15.1.1) and gluta
Hortic. Bras.. Publicado em: 2017-04
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8. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through severa
Braz J Med Biol Res. Publicado em: 12/12/2016
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9. The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats
ABSTRACT PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative sta
Acta Cir. Bras.. Publicado em: 2016-08
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10. Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats
ABSTRACT This study was done to evaluate the effects of lead nitrate and mercury chloride in testis tissues of Wistar rats. Lead nitrate and mercury chloride are widely used heavy metals in industry. Oral lead and mercury administrations to adult male rats at doses 45 mg/kg bw and 0.02 mg/kg bw, respectively for 4 weeks caused a significant increasing in MDA
Braz. arch. biol. technol.. Publicado em: 28/07/2016
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11. EVALUATION OF SUBLETHAL EFFECTS OF Ipomoea cairica LINN. EXTRACT ON LIFE HISTORY TRAITS OF DENGUE VECTORS
Plant derived insecticides have considerable potential for mosquito control because these products are safer than conventional insecticides. This study aimed to investigate sublethal activities of Ipomoea carica or railway creeper crude acethonilic extract against life history trait of dengue vectors, Aedes albopictus and Aedes aegypti. The late third instar
Rev. Inst. Med. trop. S. Paulo. Publicado em: 24/05/2016
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12. Traditional use and safety of herbal medicines
In the European Union, traditional herbal medicines that are regarded as "acceptably safe, albeit not having a recognized level of efficacy" fit into a special category of drugs ("traditional herbal medicine products") for which requirements of non-clinical and clinical studies are less rigorous. A regulation proposal published by the Brazilian National Heal
Rev. bras. farmacogn.. Publicado em: 2014-04