Mostrando 1-12 de 23 artigos, teses e dissertações.
1. Indução de edema de boca em ratos como modelo de detecção de drogas anti-inflamatórias de ação local
O presente estudo teve como objetivo desenvolver um modelo experimental de inflamação aguda na cavidade oral de ratos, tendo como padrão de comparação o edema da pata de ratos. A avaliação do edema, medido por um paquímetro, foi realizada em paralelo ao extravasamento do azul de Evans, outro indicador de atividade inflamatória nos tecidos, sob as me
IBICT. Publicado em: 02/08/2011
2. Papel do sistema histaminérgico nos processos de aprendizagem e memória em Carassius auratus após ablação cerebelar
This study investigated the effect of post-training treatment with L-histidine, Pyrilamine and Zolantidine on the memory consolidation of inhibitory avoidance in Carassius auratus submitted to cerebellar ablation. Cerebellar ablation was performed 3 days before the experiment. The inhibitory avoidance procedure included one habituation day, one training day
Publicado em: 2009
3. Participação da histamina e do receptor histaminergico H1 na nocicepção em ATM de ratos
Tem sido descrito que a administração sistêmica de antagonista de receptores histaminérgicos do tipo H1 pode amenizar a dor associada às disfunções temporomandibulares, no entanto, não se sabe se esse efeito é decorrente de uma ação central ou periférica. A literatura mostra-se escassa com relação ao papel da histamina e dos receptores histamin
Publicado em: 2003
4. Caracterização de toxinas presentes em peçonha de vespas
Peçonhas de vespas são capazes de produzir uma variedade de efeitos biológicos, tais como dor, edema, hipotensão, hepatotoxicidade e reações alérgicas. Com a exceção da peçonha da abelha Apis mellifera e de algumas (poucas) espécies de vespas sociais, as peçonhas de himenópteros brasileiros têm sido pouco estudadas. Neste trabalho, caracterizam
Publicado em: 2003
5. Desenvolvimento de um modelo comportamental de dor na ATM de ratos : participação dos receptores H1
The TMJ pain conditions are poorly understood. Considering that the subcutaneous formalin injection has been widely used as an experimental model for studying pain mechanisms, the aim of this study was to characterize the nociceptive behavioral responses induced by the formalin injection into the TMJ region of rats and verify the role of the peripheral Hl hi
Publicado em: 1999
6. Hippocampal histamine receptors and conflictive exploration in the rat: studies using the elevated asymmetric plus-maze
The possible role of histamine receptors in the hippocampal formation on the exploratory motivation and emotionality of the rat was studied. An elevated asymmetric plus-maze composed of 4 different arms (no walls, single high wall, high and low walls and two high walls) arranged at 90o angles was used. The exploration score, considered to be an index of expl
Brazilian Journal of Medical and Biological Research. Publicado em: 01/12/1997
7. Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs.
Skin mast cells release the neutral protease chymase along with histamine during degranulation. To test the hypothesis that chymase modulates histamine-induced plasma extravasation, we measured wheal formation following intradermal injection of purified mast cell chymase and histamine into the skin of ragweed-allergic dogs. We found that chymase greatly augm
8. Histamine H1 receptor activation blocks two classes of potassium current, IK(rest) and IAHP, to excite ferret vagal afferents.
1. Intracellular recordings were made in intact and acutely dissociated vagal afferent neurones (nodose ganglion cells) of the ferret to investigate the membrane effects of histamine. 2. In current-clamp or voltage-clamp recordings, histamine (10 microM) depolarized the membrane potential (10 +/- 0.8 mV; mean +/- S.E.M.; n = 27) or produced an inward current
9. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination
Analysis of mRNA from multiple sclerosis lesions revealed increased amounts of transcripts for several genes encoding molecules traditionally associated with allergic responses, including prostaglandin D synthase, histamine receptor type 1 (H1R), platelet activating factor receptor, Ig Fc ɛ receptor 1 (FcɛRI), and tryptase. We now demonstrate that, in the
The National Academy of Sciences.
10. Characterization of fluoroquinolone-induced Achilles tendon toxicity in rats: comparison of toxicities of 10 fluoroquinolones and effects of anti-inflammatory compounds.
Fluoroquinolone antibacterial agents have been reported to induce tendon lesions in juvenile rats. In the present study, we characterized fluoroquinolone-induced Achilles tendon lesions by comparing the effects of 10 fluoroquinolones and examining the potential of one of these antimicrobial agents, pefloxacin, to induce tendon lesions when coadministered wit
11. Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors
From pharmacological studies using histamine antagonists and agonists, it has been demonstrated that histamine modulates many physiological functions of the hypothalamus, such as arousal state, locomotor activity, feeding, and drinking. Three kinds of receptors (H1, H2, and H3) mediate these actions. To define the contribution of the histamine H1 recep
The National Academy of Sciences of the USA.
12. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema.
Acute ultraviolet light B (UVB) injury is associated with dermal mast cell histamine release. The possibility that histamine-stimulated prostaglandin (PG) synthesis could be a mechanism for irradiation erythema was therefore examined using human skin explants. Explants responded to UV irradiation (120 mJ/cm2) with a fivefold increase in synthesis of prostagl