Protein Structure Prediction
Mostrando 1-12 de 281 artigos, teses e dissertações.
-
1. In silico prediction of the functional and structural consequences of the non-synonymous single nucleotide polymorphism A122V in bovine CXC chemokine receptor type 1
Resumo O presente estudo objetivou avaliar se o polimorfismo causal A122V promove alterações nas propriedades funcionais e estruturais da proteína receptora de quimiocina CXC do tipo 1 (CXCR1) de bovino Bos taurus por análises in silico. Duas sequências de aminoácidos da CXCR1 bovina foram selecionadas a partir do banco de dados UniProtKB/Swiss-Prot:
Braz. J. Biol.. Publicado em: 18/04/2019
-
2. Sequence analysis of the cDNA encoding for SpCTx: a lethal factor from scorpionfish venom ( Scorpaena plumieri )
Abstract Background: Lethal factors are multifunctional oligomeric proteins found in the venomous apparatus of Scorpaeniformes fish. These toxins elicit not only an array of biological responses in vitro but also cardiovascular disorders and strong hemolytic, nociceptive and edematogenic activities in vivo. This work describes the cloning and molecular iden
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 21/09/2018
-
3. Homology modeling and epitope prediction of Der f 33
Dermatophagoides farinae (Der f), one of the main species of house dust mites, produces more than 30 allergens. A recently identified allergen belonging to the alpha-tubulin protein family, Der f 33, has not been characterized in detail. In this study, we used bioinformatics tools to construct the secondary and tertiary structures and predict the B and T cel
Braz J Med Biol Res. Publicado em: 15/03/2018
-
4. Preparation of monoclonal antibodies against gamma-type phospholipase A2 inhibitors and immunodetection of these proteins in snake blood
Abstract Background: The gamma-type phospholipase A2 inhibitor (ΡLIγ) is a natural protein commonly found in snake serum, which can neutralize pathophysiological effects of snake venom phospholipases A2. Therefore, this protein is a potential candidate to the development of a novel antivenom. To the best of our knowledge, there is no antibody currently av
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 28/09/2017
-
5. Cloning, structural modelling and characterization of VesT2s, a wasp venom hyaluronidase (HAase) from Vespa tropica
Abstract Background: Wasp venom is a complex mixture containing proteins, enzymes and small molecules, including some of the most dangerous allergens. The greater banded wasp (Vespa tropica) is well-known for its lethal venom, whose one of the major components is a hyaluronidase (HAase). It is believed that the high protein proportion and activity of this e
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 01/12/2016
-
6. Função de avaliação dinâmica em algoritmos genéticos aplicados na predição de estruturas tridimensionais de proteínas / Genetic Algorithms with Dynamic Fitness Functions Applied to Tridimensional Protein Structure Prediction
The protein structure prediction can be seen as an optimization problem where given an amino acid sequence, the tertiary protein structure must be found amongst many possible by obtaining energy functions minima. Many researchers have been proposing Evolutionary Computation strategies to find tridimensional structures of proteins; however results are not alw
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/09/2012
-
7. Algoritmo evolutivo de muitos objetivos para predição ab initio de estrutura de proteínas / Multiobjective evolutionary algorithm with many tables to ab initio protein structure prediction
Este trabalho foca o desenvolvimento de algoritmos de otimização para o problema de PSP puramente ab initio. Algoritmos que melhor exploram o espaço de potencial de soluções podem, em geral, encontrar melhores soluções. Esses algoritmos podem beneficiar ambas abordagens de PSP, tanto o modelo ab initio quanto os baseados em conhecimento a priori. Pesq
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/05/2012
-
8. Avaliação do valor de predição de clivagem química de radicais hidroxila em regiões promotoras de genes ligados ao desenvolvimento craniofacial / Evaluation of predictive value for chemical cleavage of hydroxy radicals in the promoter regions of genes related to craniofacial developmentl
The initiation of the gene transcription is a very complex phenomenon, probably the principal stage where the control of the gene expression takes place. In general terms the transcription takes place with the connection of proteins called "transcription factors" with specific sequences of the DNA, called of regions or sequences "cis ". The interaction DNA -
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
-
9. Uso de estratégias baseadas em conhecimento para algoritmos genéticos aplicados à predição de estruturas tridimensionais de proteínas / Knowledge-based Approach to Genetic Algorithms for the Protein Structure Prediction Problem
Proteínas desempenham uma grande variedade de funções biológicas. O conhecimento da estrutura tridimensional proteica pode ajudar no entendimento da função desempenhada. De acordo com a hipótese de Anfisen, a estrutura terciária nativa de uma proteína pode ser determinada a partir da informação contida na sequência primária, o que permitiria que
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/05/2011
-
10. Prediction of binding hot spot residues by using structural and evolutionary parameters.
In this work, we present a method for predicting hot spot residues by using a set of structural and evolutionary parameters. Unlike previous studies, we use a set of parameters which do not depend on the structure of the protein in complex, so that the predictor can also be used when the interface region is unknown. Despite the fact that no information conce
Genetics and Molecular Biology. Publicado em: 2011
-
11. PredIP: an in silico approach for automated protein interaction prediction in genomic and transcriptomic sequence databanks.
The fast-growing amount of protein interaction databanks have made possible to analyze deeply several metabolic or signaling pathways in different organisms. The information available in such databanks can be used to predict new protein interactions in transcriptome or proteome sequences, most of times this task is done by sequence homology or by structure s
INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY. Publicado em: 2011
-
12. Protein structure comparison via contact map alignment / Protein structure comparison via contact map alignment
Proteins are primary components in almost all biological processes in living organisms. It is known that the variety of protein functions is a result of the differences in protein structures. Therefore, understanding and comparing the structure of proteins is a major challenge in modern molecular biology. The structural alignment and comparison of proteins b
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/02/2010