Pharmacological Evaluation
Mostrando 1-12 de 199 artigos, teses e dissertações.
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1. Treatment-resistant bipolar depression: concepts and challenges for novel interventions
Treatment-resistant bipolar depression (TRBD) has been reported in about one-quarter of patients with bipolar disorders, and few interventions have shown clear and established effectiveness. We conducted a narrative review of the published medical literature to identify papers discussing treatment-resistant depression concepts and novel interventions for bip
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Dependence on hypnotics: a comparative study between chronic users of benzodiazepines and Z-drugs
Objective: To evaluate dependence among chronic benzodiazepine and Z-drug users in Brazil. Methods: Chronic users of benzodiazepines (n=94), Z-drugs (n=74), or both (n=11) were recruited from the community, underwent a psychiatric evaluation and completed self-report instruments on hypnotic dependence, insomnia, anxiety, and depression. Users of benzodiazep
Brazilian Journal of Psychiatry. Publicado em: 2022
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3. Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives
Chikungunya virus (CHIKV) is a re-emerging disease caused by an alphavirus of the Togaviridae family. Since its first description in 1952, the disease has spread worldwide, affecting populations in both tropical and temperate countries. To date, there is no licensed vaccine or specific pharmacological treatment. Therefore, there is an increasing urgency in d
Journal of the Brazilian Chemical Society. Publicado em: 2022
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4. Non-pharmacological Interventions for Improving Sleep Quality During Pregnancy: A Systematic Review and Meta-Analysis
Resumo Objetivo Investigar o efeito de intervenções não-farmacológicas para melhorar a qualidade do sono durante a gravidez. Fontes dos dados Uma busca foi feita nas bases de dados NBCI/PubMed, ClinicalTrials.gov, Embase, BVS, e Web of Science. Não houve limitações quanto ao idioma, tamanho da amostra e tipo de intervenção não-farmacológica. Inc
Revista Brasileira de Ginecologia e Obstetrícia. Publicado em: 2022
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5. Evaluation of Caripill™ as a component of platelet storage solution
ABSTRACT Background Carica papaya Linn. has high nutraceutical and pharmacological values. The leaves possess antimicrobial, anti-tumor and antioxidant properties. They are used to treat thrombocytopenia during dengue fever and the leaf extract is commercially available as tablets under the name Caripill™ (MicroLabs, Bengaluru). Nevertheless, platelet tra
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
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6. Improvement in borderline personality disorder symptomatology after repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: preliminary results
Objective: Current treatment for borderline personality disorder (BPD) involves psychological and pharmacological interventions. However, neuromodulation techniques such as repetitive transcranial magnetic stimulation (rTMS) may positively affect BPD symptomatology. The objective of this study was to evaluate the clinical and neuropsychological effects of r
Braz. J. Psychiatry. Publicado em: 2021-02
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7. New Synthetic Quinolines as Cathepsin K Inhibitors
Cathepsin K is a papain-like cysteine protease and is responsible for collagen degradation in bone tissue and thus represents an important target for the development of new therapies for treating diseases such as osteoporosis. Quinolines are an important class of heterocyclic molecular leads with a great pharmacological potential and represent a relevant sca
J. Braz. Chem. Soc.. Publicado em: 2020-08
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8. Theoretical and Experimental Investigations on Inclusion Complex β-Cyclodextrin and Sulcatone: A Cardiovascular Activity Evaluation
In this paper, we have applied state-of-the-art technologies and new investigations were developed focusing on obtaining simple and inexpensive molecules for treating cardiovascular diseases, as they are considered the leading cause of death in the world. For the first time, the inclusion complex of sulcatone (SU) and β-cyclodextrin (β-CD) was achieved (us
J. Braz. Chem. Soc.. Publicado em: 2020-05
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9. Evaluating the disease and treatment information provided to patients with chronic obstructive pulmonary disease at the time of discharge according to GOLD discharge guidelines
RESUMO Objetivo Avaliar informações sobre a doença e o tratamento fornecidos a pacientes com doença pulmonar obstrutiva crônica no momento da alta hospitalar. Métodos Estudo transversal incluindo pacientes internados com doença pulmonar obstrutiva crônica de três hospitais terciários. O estudo baseou-se em sete itens das diretrizes de alta hospit
Einstein (São Paulo). Publicado em: 09/12/2019
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10. Evaluation of adherence to pharmacological treatment
The adherence to therapy associated with the socio-demographic variables and the habits of patients with hypertension and/or diabetes mellitus were investigated in this study. The registration forms of 105 patients in the Hiperdia program in the municipality of Campina Grande-PB were used as a data collection instrument, applying the Morisky-Green test (MGT)
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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11. Evaluation of the immunomodulatory effect against splenocytes of Balb/c mice of biflorin obtained from Capraria biflora by a new isolation method
Abstract Biflorin (6,9-dimethyl-3-(4-methylpent-3-en-1-yl) benzo[de]chromene-7,8-dione) is a promising substance that has been increasingly studied in the past decades due to its diverse pharmacological properties (i.e. antitumor, antioxidant, antiinflamatory, antimicrobial activity etc.). Aiming the comprehension of its antitumoral activity we investigated
Rev. bras. farmacogn.. Publicado em: 17/10/2019
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12. Pharmacological evaluation of the hydro-alcoholic extract of Campomanesia phaea fruits in rats
Resumo Campomanesia phaea (Myrtaceae), popularmente conhecida como cambuci, é uma das várias espécies de plantas que produzem frutos comestíveis amplamente utilizados na nutrição humana. Apesar de seu consumo e potencial econômico, há poucas pesquisas científicas sobre a Campomanesia, especialmente aquelas relacionadas aos seus benefícios terapêut
Braz. J. Biol.. Publicado em: 07/10/2019