Parasite Biochemistry
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Estudo do metabolismo energético de Leishmania spp utilizando cromatografia líquida de alta eficiência e ressonância magnética nuclear / Study of energy metabolism of Leishmania spp using high performance liquid chromatography and nuclear magnetic resonance
A leishmaniose é uma doença do sistema mononuclear fagocitáio causada por protozoários do gênero Leishmania. As formas promastigotas de Leishmania sp degradam carboidratos pela via glicolítica e a primeira reação ocorre dentro do glicossomo. Utilizando como fonte de energia a glicose, aminoácidos e lipídeos presentes no meio de cultura, os produtos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/09/2011
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2. Estudo do metabolismo energético de Leishmania spp utilizando cromatografia líquida de alta eficiência e ressonância magnética nuclear / Study of energy metabolism of Leishmania spp using high performance liquid chromatography and nuclear magnetic resonance
A leishmaniose é uma doença do sistema mononuclear fagocitáio causada por protozoários do gênero Leishmania. As formas promastigotas de Leishmania sp degradam carboidratos pela via glicolítica e a primeira reação ocorre dentro do glicossomo. Utilizando como fonte de energia a glicose, aminoácidos e lipídeos presentes no meio de cultura, os produtos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/09/2011
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3. Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation - A Review
Human malignant malaria is caused by Plasmodium falciparum and accounts for almost 900,000 deaths per year, the majority of which are children and pregnant women in developing countries. There has been significant effort to understand the biology of P. falciparum and its interactions with the host. However, these studies are hindered because several aspects
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-12
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4. Dinâmica da infecção experimental de cães por Ehrlichia canis: aspectos clínicos, laboratoriais e resposta imune humoral e celular / Dynamics of experimental Ehrlichia canis infection of dogs: clinical and laboratorial aspects and humoral and cellular immune response
The clinical evolution, the persistence of infection and humoral and cellular immune response were evaluated on seven adult naïve dogs experimentally inoculated with an E. canis strain and followed during 20 weeks. Three dogs were remained as control. Daily clinical evaluation and laboratorial exams (hematological, biochemistry, erythrocyte osmotic fragilit
Publicado em: 2005
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5. Antimalarial Quinones for Prophylaxis Based on a Rationale of Inhibition of Electron Transfer in Plasmodium*
Knowledge of the biochemistry of Plasmodium is emerging as a new field. Previous studies showed that the parasite apparently requires electron transfer for energy, and techniques to study such energy mechanisms are available. The discovery of the existence of coenzyme Q8 in Plasmodium implies an indispensable functionality for this redox entity in the electr
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6. Pathogenesis of Intestinal Amebiasis: From Molecules to Disease
In spite of a wealth of knowledge on the biochemistry and cellular and molecular biology of Entamoeba histolytica, little has been done to apply these advances to our understanding of the lesions observed in patients with intestinal amebiasis. In this review, the pathological and histological findings in acute amebic colitis are related to the molecular mech
American Society for Microbiology.
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7. Potent and Selective Activity of a Combination of Thymidine and 1843U89, a Folate-Based Thymidylate Synthase Inhibitor, against Plasmodium falciparum
Unlike mammalian cells, malarial parasites are completely dependent on the de novo pyrimidine pathway and lack the enzymes to salvage preformed pyrimidines. In the present study, first, it is shown that 1843U89, even without polyglutamylation, is a potent folate-based inhibitor of purified malarial parasite thymidylate synthase. The binding was noncompetitiv
American Society for Microbiology.
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8. Molecular cloning of a serine proteinase inhibitor from Brugia malayi.
The antigens produced by the infective-stage larvae of filarial parasites are potentially important targets for a protective immune response. A major impediment to studies on the biochemistry and molecular biology of antigens from infective larvae is a lack of parasite material. By employing a reverse transcription PCR-based strategy which exploited the pres