Paradigm
Mostrando 1-12 de 2030 artigos, teses e dissertações.
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1. Gene Silencing Therapeutics in Cardiology: A Review Article
Abstract Therapeutics that inhibit enzymes, receptors, ion channels, and cotransporters have long been the mainstay of cardiovascular medicine. Now, oligonucleotide therapeutics offer a modern variation on this paradigm of protein inhibition. Rather than target a protein, however, small interfering ribonucleic acids and antisense oligonucleotides target the
International Journal of Cardiovascular Sciences. Publicado em: 2022
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2. Aortic Root and Distal Arch Management During Type A Aortic Dissection Repair: Expanding Horizons
ABSTRACT The management of Type A aortic dissection has evolved over a period of a decade or so, and contemporary reports are suggesting a paradigm shift from a conservative approach to complete excision of the diseased aorta including root and distal arch. Improved cardiopulmonary bypass perfusion techniques, better understanding of the cerebral perfusion,
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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3. THE TWO “MULTIS” AND THE MULTILITERACIES PEDAGOGY: “SHAKING HANDS” IN THE BRAZILIAN ENGLISH PUBLIC EDUCATION FOR TEENS
Abstract 1English school textbooks have a long tradition in the Brazilian public sector of education. Most often they are the only pedagogical resources in an English classroom. English public textbooks are submitted to a National Program for evaluation and this educational policy has had positive impacts on these materials. This article analyzes one of the
Ilha do Desterro. Publicado em: 2022
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4. REPLY TO “PREDICTIVE PROCESSING AND THE SEMIOLOGICAL PRINCIPLE: COMMENTARY TO DUFFLEY”
Abstract My notion of stable word meaning could correspond either to the root-node or the whole of a neurally-organized package and acknowledge that linguistic processing is largely holistic. The existence of words as context-free entities is not just a “cognitive idealization” however but a necessity, as otherwise speakers would have to make up their wo
Manuscrito. Publicado em: 2022
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5. Evening chronotype as a bipolar feature among patients with major depressive disorder: the results of a pilot factor analysis
Objectives: The bipolar spectrum concept has resulted in a paradigm shift that has affected both the diagnosis and therapy of mood disorders, with bipolarity becoming an indicator of treatment resistance in depression. Evening circadian preference has also been linked to affective disorders. The aim of our study was to confirm the relationship between the se
Brazilian Journal of Psychiatry. Publicado em: 2022
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6. Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores
Abstract Introduction Treatment of stage III laryngeal cancer suffered a major paradigm change with surgery being substituted by radiation therapy with chemotherapy. Objective To evaluate the oncological outcome of different treatment modalities for stage III laryngeal cancer using a population database. Methods A population database representing patients
International Archives of Otorhinolaryngology. Publicado em: 2022
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7. Analysis of the use of educational materials by radiologists and radiology residents in Brazil: paradigm shift
Resumo Objetivo: Identificar o perfil de utilização dos recursos didáticos pelos médicos radiologistas e residentes em radiologia e diagnóstico por imagem brasileiros. Materiais e Métodos: Estudo observacional, transversal e descritivo, realizado por meio de questionário eletrônico contendo perguntas referentes ao perfil do médico, formação, loc
Radiologia Brasileira. Publicado em: 2022
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8. Does mismatch negativity have utility for NMDA receptor drug development in depression?
Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical and logis
Brazilian Journal of Psychiatry. Publicado em: 2022
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9. Holmium laser ablation of the prostate (HoLAP) with moses technology for the surgical treatment of benign prostatic hyperplasia
ABSTRACT Purpose: The expansion of technology is leading to a paradigm shift in several urological fields (1, 2). In particular, the adoption of lasers within the surgical treatment of patients with benign prostatic hyperplasia (BPH) is considered one of the most relevant innovations (3-5). In this video, we aimed to report our experience with holmium laser
International braz j urol. Publicado em: 2022
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10. Evaluation of Recurrence and Hearing Outcome for Inactive Squamosal Disease after Cartilage Strengthening Tympanoplasty
Abstract Introduction Inactive squamosal disease is unique for having a conflicting treatment protocol, with an age-old debate between early surgical intervention or keeping patients in a long-term follow-up. The shifting paradigm is early intervention to prevent further progress into active disease and improve hearing outcome in its nascent stage. Objecti
International Archives of Otorhinolaryngology. Publicado em: 2022
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11. Multi-stage dumping sequence - a feasible waste management alternative for open pit mining
Abstract Waste management and environmental aspects are progressively gathering attention in the mining industry. Mine planners must deal with increasingly complex tasks to balance between ore block schedules, waste disposal, operational cost and environmental reclamation. The mine incomes are generally related to mining and processing of the ore, thus most
REM, Int. Eng. J.. Publicado em: 2021-06
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12. IMAGINATION, RELIGION, LANGUE Trois vecteurs de la révolution pédagogique fichtéenne des Discours à la Nation Allemande
ABSTRACT By allowing the intellection of a universal horizon for the human kind, education has found its place in the anthropological core of Enlightenment. Strongly influenced by this conceptual frame in his youth, Fichte has however witnessed the limits of this pedagogical paradigm when it comes to understanding the historical processes of collective learn
Kriterion. Publicado em: 2021-04