Orofacial Dyskinesia
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. An examination of synaptic proteins following chronic haloperidol in a rat model of tardive dyskinesia
Tardive dyskinesia (TD) is a late-onset side effect mainly affecting the orofacial region of patients treated chronically with classic antipsychotic drugs such as haloperidol (HAL). The causes of TD remain unknown. We hypothesized that faulty synaptic re-organization might be related to TD-like syndromes and used the vacuous chewing movements (VCM) model in
Psychology & Neuroscience. Publicado em: 2010-12
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2. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Publicado em: 2010
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3. EFEITOS DOS NEUROLÉPTICOS ATÍPICOS ZIPRASIDONA E AMISULPRIDA EM MODELOS ANIMAIS DE DISCINESIA TARDIA.
Tardive dyskinesia - the main side effect of long-term treatment with typical neuroleptics - has been related to nigrostriatal dopaminergic supersensitivity. Treatment with atypical neuroleptics is associated with a decreased risk for development of tardive dyskinesia. The aim of the present study was to verify the effects of several doses the atypical neuro
Publicado em: 2009
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4. INGESTÃO DA TINTURA DE VALERIANA OFFICINALIS PROTEGE DA DISCINESIA OROFACIAL INDUZIDA POR RESERPINA EM RATOS / INTAKE OF THE VALERIANA OFFICINALIS TINCTURE PROTECTS AGAINST OROFACIAL DYSKINESIA INDUCED BY RESERPINE IN RATS
Considerando as hipóteses do papel da neurotransmissão gabaérgica e do estresse oxidativo no desenvolvimento de movimentos orais associados a neuropatologias importantes, o presente estudo investigou a possível habilidade da tintura de V. officinalis na prevenção dos movimentos de mascar no vazio (MMV) induzidos por reserpina em ratos. Os animais foram
Publicado em: 2009
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5. INFLUÊNCIA DO ÔMEGA 3 SOBRE SINTOMAS EXTRAPIRAMIDAIS, DEFICIÊNCIA COGNITIVA E PARÂMETROS DE ESTRESSE OXIDATIVO EM ANIMAIS TRATADOS COM NEUROLÉPTICOS
Haloperidol and fluphenazine are typical neuroleptics widely used in the treatment of mental illness, whose chronic use is associated with adverse effects that affect the motor function and memory, among others. The motor disturbances can be moderate, and include parkinsonism, akathisia, dystonia, but also a more severe syndrome, known as tardive dyskinesia
Publicado em: 2009
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6. ROLE OF DOPAMINE UPTAKE AND THEIR METABOLITES IN THE OROFACIAL DYSKINESIA INDUCED BY NEUROLEPTICS IN RATS / PAPEL DA RECAPTAÇÃO E DE METABÓLITOS DA DOPAMINA NA DISCINESIA OROFACIAL INDUZIDA POR NEUROLÉPTICOS EM RATOS
Fluphenazine-induced orofacial dyskinesia (OD) is a putative animal model of tardive dyskinesia (TD) whose pathophysiology has been related to an increase in dopamine hypersensitivity and oxidative stress. Data from literature have shown that patients with TD present a decrease in dopamine transporter (DAT) expression. In a previously study, we have demonstr
Publicado em: 2008
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7. INFLUENCE OF PHYSICAL EXERCISE ON BEHAVIORAL PARAMETERS AND OXIDATIVE STRESS IN AN ANIMAL MODEL OF TARDIVE DYSKINESIA / IFLUÊNCIA DO EXERCÍCIO FÍSICO SOBRE PARÂMETROS DE COMPORTAMENTO E ESTRESSE OXIDATIVO EM MODELO ANIMAL DE DISCINESIA TARDIA
Regular practice of physical activity promotes beneficial effects to the body. However, excessive duration and intensity of exercise may surpass individual tolerance to exercise, generating oxidative stress (OS). Studies have shown these effects in various organs, such as the heart and muscles, but little is known about their action and mechanisms in the bra
Publicado em: 2008
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8. Pharmacology and toxicology of diphenyl diselenide in several biological models
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in
Brazilian Journal of Medical and Biological Research. Publicado em: 21/08/2007
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9. EFFECT OF HIGH FAT DIET AND OF Valeriana officinalis TINCTURE ON THE CHRONIC MODEL OF OROFACIAL DYSKINESIA INDUCED BY HALOPERIDOL IN RATS / EFEITO DA DIETA HIPERLIPÍDICA E DA TINTURA DE Valeriana officinalis NO MODELO CRÔNICO DE DISCINESIA OROFACIAL INDUZIDA POR HALOPERIDOL EM RATOS
A discinesia orofacial (DO) induzida por haloperidol consiste num modelo de discinesia tardia (DT) cuja patofisiologia tem sido relacionada a um aumento na renovação de dopamina, à redução na neurotransmissão gabaérgica e ao estresse oxidativo. Existem relatos de que pacientes esquizofrênicos ingerem uma maior quantidade de gordura na dieta do que a
Publicado em: 2006
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10. A comparison of purposeless movements in psychiatric patients treated with antipsychotic drugs, and normal individuals.
Oro-facial dyskinesia and purposeless trunk and limb movements were assessed, using a standard videotape rating technique, in 182 psychiatric patients receiving antipsychotic medication, in a second sample of 43 elderly psychiatric patients also receiving antipsychotic drugs, and 85 normal, drug-naive subjects. In both the first patient sample and the group
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11. Striatal dopamine D2 receptors in tardive dyskinesia: PET study.
The dopamine D2 receptors were investigated in vivo in eight neuroleptic-free patients with persistent tardive dyskinesia using positron emission tomography and 76Br-bromospiperone. The striatal receptor density, estimated by the striatum/cerebellum radioligand concentration ratio, was not elevated in patients as compared with age-matched controls but was po
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12. Involuntary orofacial movements in hospitalised patients with mental handicap or epilepsy: relationship to developmental/intellectual deficit and presence or absence of long-term exposure to neuroleptics.
Among 42 adult patients with mental handicap who had received treatment with neuroleptic drugs, the prevalence of orofacial dyskinesia increased with age and those with such involuntary movements were characterised by a considerably greater degree of mental handicap. Similar associations were found among a group of 15 patients with epilepsy. Two of seven oth