Neurotoxin
Mostrando 1-12 de 303 artigos, teses e dissertações.
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1. [PROVISIONAL] Genome sequence of Shewanella corallii strain A687 isolated from pufferfish (Sphoeroides spengleri)
Abstract We present here the genome sequence of Shewanella corallii strain A687 isolated from pufferfish Sphoeroides spengleri (Family Tetraodontidae). The assembly consists of 5,215,037 bp and contains 284 contigs, with a G+C content of 50.3%. The genus Shewanella comprises 67 recognized species. These bacteria are Gram-negative, rod-shaped, facultatively a
Genet. Mol. Biol.. Publicado em: 02/09/2019
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2. The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
RESUMO: Estudos têm demonstrado a desnervação simpática cardíaca no modelo da administração do MPTP em camundongo. A toxicidade do MPTP causa lesão ao nervo simpático e depleção da norepinefrina. As avaliações dos danos na inervação do coração são baseadas em métodos de imagem, eletrofisiológico e bioquímico. Contudo, estes estudos carec
Pesq. Vet. Bras.. Publicado em: 01/07/2019
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3. Crotalus durissus terrificus crotapotin naturally displays preferred positions for amino acid substitutions
Abstract Background Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin. Crotoxin is a non-covalent heterodimeric neurotoxin constituted of two subunits: an active phospholipase A2 and a chaperone p
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/12/2017
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4. Lysozyme gene treatment in testosterone induced benign prostate hyperplasia rat model and comparasion of its’ effectiveness with botulinum toxin injection
ABSTRACT Objectives: To compare the effects and histopathological changes of botulinum neurotoxin type A and lysozyme gene injections into prostate tissue within a testosterone induced benign prostate hyperplasia rat model. Materials and Methods: 40 male Wistar rats were randomized into four Groups. Group-1: Control, Group-2: Testosterone replacement, Grou
Int. braz j urol.. Publicado em: 2017-12
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5. Long-term response of different Botulinum toxins in refractory neurogenic detrusor overactivity due to spinal cord injury
ABSTRACT Purpose To assess the response in spinal cord injured patients alternatively treated with different types and dosages of Botulinum neurotoxin type A (BoNT/A) over 15 years. Material and methods Patients who underwent first BoNT/A from 1999-2001 and practiced intermittent catheterization were included. Baseline 3-day bladder diary (BD) and urodyn
Int. braz j urol.. Publicado em: 2017-08
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6. Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis
Abstract Background The cysteine-rich neurotoxins from elapid venoms are primarily responsible for human and animal envenomation; however, their low concentration in the venom may hamper the production of efficient elapid antivenoms. Therefore, the aim of the present study was to produce fully active elapid neurotoxic immunogens for elapid antivenom produc
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 13/10/2016
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7. A comparison between the recombinant expression and chemical synthesis of a short cysteine-rich insecticidal spider peptide
Abstract Background: The choice between heterologous expression versus chemical synthesis for synthesizing short cysteine-rich insecticidal peptides from arthropods may impact the obtainment of yields and well-folded bioactive molecules for scientific research. Therefore, two recombinant expression systems were compared to
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/08/2015
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8. Detection and identification of huwentoxin-IV interacting proteins by biotin-avidin chemistry combined with mass spectrometry
Background : Numerous spider toxins are of interest as tools for neurophysiological research or as lead molecules for the development of pharmaceuticals and insecticides. Direct detection and identification of the interacting proteins of a spider toxin are helpful for its action-mechanism analysis and practical application. The present study employed a com
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/05/2014
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9. Avaliação funcional dos eosinófilos na anemia falciforme e o efeito do tratamento com hidroxiureia / Altered functional properties of eosinophils in sickle cell anemia and effects of hydroxyurea therapy
Sickle cell anemia is the homozygous state for hemoglobin S. Inflammation plays an important role in the vaso-occlusive process of the disease, where leukocytes, proinflammatory cytokines and adhesion molecules are increased in the peripheral blood of patients with sickle cell anemia. Leukocytosis is associated with morbidity and mortality in these patients.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/05/2011
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10. Avaliação dos Movimentos Periódicos Das Patas Na Síndrome Das Pernas Inquietas, Utilizando Um Modelo Animal Induzido Pela Lesão Do Núcleo Dopaminérgico A11 Com A 6-Hidroxidopamina / Evaluation of Periodic Limb Movements in Restless Legs Syndrome, using an animal model induced by Injury of A11 dopamine nucleus with 6-Hydroxydopamine
Background: Restless Legs Syndrome (RLS) is a major healthcare burden of increasing prevalence. It has been demonstrated that periodic limb movements in sleep (PLM) can occur as an isolated phenomenon, but they are often associated with RLS and represent the only symptom of this disorder that can be measured electrophysiologically. The aim of this study was
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2011
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11. Adaptive evolution of the vertebrate skeletal muscle sodium channel
Tetrodotoxin (TTX) is a highly potent neurotoxin that blocks the action potential by selectively binding to voltage-gated sodium channels (Na v). The skeletal muscle Na v (Na v1.4) channels in most pufferfish species and certain North American garter snakes are resistant to TTX, whereas in most mammals they are TTX-sensitive. It still remains unclear as to w
Genetics and Molecular Biology. Publicado em: 2011
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12. Isolation and structural and functional characterization of Ts15, a new neurotoxin from the venom of the scorpion Tityus serrulatus / Isolamento e caracterização estrutural e funcional da Ts15, uma nova neurotoxina da peçonha do escorpião Tityus serrulatus
Os escorpiões são um dos grupos de animais mais antigos da Terra. Eles são artrópodes e pertecem a classe Arachinida e Ordem Scorpionida. A família Buthidae compreende as espécies responsáveis pelos acidentes graves em humanos, incluindo a espécie Tityus serrulatus, o maior responsável por esses acidentes no Brasil. A peçonha do T. serrulatus cont�
Publicado em: 2010