Neurotoxicity
Mostrando 13-24 de 278 artigos, teses e dissertações.
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13. Beneficial effects of β-glucan against cisplatin side effects on the nervous system in rats 1
ABSTRACT PURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, βg was orally administered at the
Acta Cir. Bras.. Publicado em: 2016-03
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14. Homocysteine induces glyceraldehyde-3-phosphate dehydrogenase acetylation and apoptosis in the neuroblastoma cell line Neuro2a
High plasma levels of homocysteine (Hcy) promote the progression of neurodegenerative diseases. However, the mechanism by which Hcy mediates neurotoxicity has not been elucidated. We observed that upon incubation with Hcy, the viability of a neuroblastoma cell line Neuro2a declined in a dose-dependent manner, and apoptosis was induced within 48 h. The median
Braz J Med Biol Res. Publicado em: 19/01/2016
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15. Selenium protects cerebral cells by cisplatin induced neurotoxicity
PURPOSE:To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium.METHODS:Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered to CS and CSE groups for three days. Furthermore, C
Acta Cir. Bras.. Publicado em: 2015-06
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16. Presynaptic neuromuscular action of a methanolic extract from the venom of Rhinella schneideri toad
Background Rhinella schneideri, previously known as Bufo paracnemis, is a common toad in many regions of Brazil. Its venom exerts important cardiovascular effects on humans and other animals. Although this toad venom has been the subject of intense investigations, little is known about its neuromuscular activity. Methods The neurotoxicity of a methanolic
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/09/2014
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17. Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damage is complex and involves interactions of the drug with several neurotransmitter
Braz J Med Biol Res. Publicado em: 15/10/2013
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18. Caracterização das vias de morte celular induzida pela metilecgonidina, produto da pirólise da cocaína / Neurotoxicity of anydroecgonine methyl ester, a crack cocaine pyrolysis product
A cocaína é considerada a principal droga de abuso utilizada na América do Sul, sendo que o crack é a via de administração que mais cresceu nos últimos anos. Cabe salientar que o usuário do crack sofre ação tanto da cocaína quanto das substâncias advindas da sua pirólise, dentre elas a metilecgonidina (AEME). Trabalho publicado pelo nosso grupo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/10/2012
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19. Estudo das ações neurotóxica, miotóxica e pró-inflamatória da PLA2 BrTX-I, isolada do veneno de Bothrops roedingeri (Jérgon da Costa) : caracterização bioquímica e farmacológica in vivo e ex vivo / Study of neurotoxic, myotoxic and proinflammatory actions of BrTX-I PLA2, isolated from Bothrops roedingeri (Jergon Coast) : biochemical and pharmacological characterization in vivo and ex vivo
Uma grande variedade de toxinas provenientes de venenos animais tem sido largamente utilizada no estudo de mecanismos de ação e processos fisiológicos, sendo consideradas valiosas ferramentas moleculares. As serpentes peçonhentas expressam no veneno diversas proteínas muito estudadas e utilizadas clinicamente, apresentando diferentes graus de variabilid
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/10/2012
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20. Efeito do acetato de chumbo associado ou não ao sulfato ferroso em cérebro de ratos: análise das enzimas antioxidantes / Effect of lead acetate with or without iron sulfate in brain of rats: Analysis of antioxidant enzymes
Lead (Pb2+) is a toxic heavy metal, found in all stages of the inert environment and in several biological systems. When uptaken by the organism, acts on several organs and systems and may cause severe damage in Central Nervous System. In addition, it has been reported that iron (Fe2+) may present, a protective effect on neurotoxicity caused by Pb2+. Therefo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/09/2012
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21. Evaluation of the neurotoxic effects of ayahuasca tea / Avaliação dos efeitos neurotóxicos do chá ayahuasca
Ayahuasca tea is a psychotropic beverage that has caused controversy due to the fact of being used indiscriminately by some group of people and the ease of purchase in the worldweb. The tea is derived by boiling the bark of the liana Banisteriopsis Caapi (B. Caapi) together with the leaves of Psychotria Viridis (P.Viridis). B. Caapi contains alkaloids as har
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/06/2012
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22. Avaliação do modelo de hiperargininemia sobre parâmetros neuroquímicos, moleculares e compartamentais em peixe-zebra (Danio rerio): uma abordagem sobre o sistema purinérgico
Hyperargininemia is a rare disease caused by an innate error of the metabolism (EIM) biochemically characterized by the accumulation of arginine in body tissues due to arginase deficits. Mental retardation and other neurological symptoms are common in hyperargininemic patients. Several mechanisms have been proposed to describe the neurotoxicity of hiperargin
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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23. 2,2-DISSELENETO DE DITIENILA, UM COMPOSTO ORGÂNICO DE SELÊNIO COM ATIVIDADE ANTIOXIDANTE E NEUROPROTETORA EM RATOS / 2,2-DITHIENYL DISELENIDE, AN ORGANOSELENIUM COMPOUND WITH ANTIOXIDANT AND NEUROPROTECTIVE ACTIVITIES IN RATS
O estresse oxidativo tem sido implicado na patofisiologia de diversas doenças neurológicas uma vez que o cérebro é um órgão altamente susceptível ao dano oxidativo. A epilepsia do lobo temporal (ELT) tem sido amplamente estudada devido à alta taxa de prevalência e refratariedade ao tratamento medicamentoso. Além disso, a ELT pode estar associada co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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24. Estudo da atividade tipo-ansiolítica das folhas de Pimenta pseudocaryophyllus (Gomes) L.R. Landrum - Myrtaceae / Anxiolity - like activity of the leaves of Pimenta pseudocaryophyllus (Gomes) L.R. Landrum - Myrtaceae
Pimenta pseudocaryophyllus, popularly known as Craveiro, is the only species in this genus native to the cerrado of Brazil. Ethnopharmacological studies revealed medicinal use of P. pseudocaryophyllus extracts in treating menstrual and digestive problems as well as emotional tension in the form of soothing tea among other therapeutic applications in Brazilia
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/02/2012