L Amino Acid Oxidase
Mostrando 1-12 de 116 artigos, teses e dissertações.
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1. Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins
Abstract Background: Tityus serrulatus venom (Ts venom) is a complex mixture of several compounds with biotechnological and therapeutical potentials, which highlights the importance of the identification and characterization of these components. Although a considerable number of studies have been dedicated to the characterization of this complex cocktail, t
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/04/2019
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2. Purification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom
Abstract Background: Lachesis muta rhombeata (Lmr) is the largest venomous snake in Latin America and its venom contains mainly enzymatic components, such as serine and metalloproteases, L-amino acid oxidase and phospholipases A2. Metalloproteases comprise a large group of zinc-dependent proteases that cleave basement membrane components such as fibronectin
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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3. Enzyme kinetic modelling and analytical solution of nonlinear rate equation in the transformation of D-methionine into L-methionine in batch reactor using the new homotopy perturbation method
A mathematical model of biotransformation of D-methionine into L-methionine in the cascade of the enzymes such as, D-amino acid oxidase (D-AAO), L-phenylalanine dehydrogenase (L-PheDH) and formate dehydrogenase (FDH) is discussed. The model is based on a system of coupled nonlinear reaction equations under non steady-state conditions for biochemical reaction
Quím. Nova. Publicado em: 2016-12
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4. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines
ABSTRACT BACKGROUND: Myeloproliferative neoplasms are Philadelphia chromosome-negative diseases characterized by hyperproliferation of mature myeloid cells, associated or not with the Janus kinase 2 tyrosine kinase mutation, JAK2V617F. As there is no curative therapy, researchers have been investigating new drugs to treat myeloproliferative neoplasms, incl
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-06
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5. Bordonein-L, a new L-amino acid oxidase from Crotalus durissus terrificus snake venom: isolation, preliminary characterization and enzyme stability
BackgroundCrotalus durissus terrificus venom (CdtV) is one of the most studied snake venoms in Brazil. Despite presenting several well known proteins, its L-amino acid oxidase (LAAO) has not been studied previously. This study aimed to isolate, characterize and evaluate the enzyme stability of bordonein-L, an LAAO from CdtV.Methods The enzyme was isolated th
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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6. Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes. The present study aimed to assess whether Bothrops jararacussuand Bothrops pirajai crude venoms and their isolated toxins, namely serine
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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7. Comparative analysis of the venom proteome of four important Malaysian snake species
Background Naja kaouthia, Ophiophagus hannah, Bungarus fasciatus and Calloselasma rhodostoma are four venomous snakes indigenous to Malaysia. In the present study, their proteomic profile by two-dimensional gel electrophoresis (2-DE) have been separated and compared. Results The 2-DE of venoms of the four species snake demonstrated complexity and obvious
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 04/03/2014
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8. Caracterização parcial e avaliação do potencial antibacteriano e antitumoral de uma L-aminoácido oxidase isolada de Bothrops jararacussu / Partial characterization and evaluation of antibacterial and antitumor potential of an L-amino acid oxidase obtained of Bothrops jararacussu
Os venenos de serpentes são misturas ricas em proteínas, enzimas e peptídeos biologicamente ativos, os quais representam aproximadamente 90% dos constituintes totais e, provavelmente, são responsáveis por grande parte dos efeitos biológicos do veneno. A L-aminoácido oxidase (LAAO) é uma das enzimas encontradas nos venenos e muitos são os efeitos atr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/01/2012
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9. DNA multigene sequencing of topotypic specimens of the fascioliasis vector Lymnaea diaphana and phylogenetic analysis of the genus Pectinidens (Gastropoda)
Freshwater lymnaeid snails are crucial in defining transmission and epidemiology of fascioliasis. In South America, human endemic areas are related to high altitudes in Andean regions. The species Lymnaea diaphana has, however, been involved in low altitude areas of Chile, Argentina and Peru where human infection also occurs. Complete nuclear ribosomal DNA 1
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-02
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10. Purification and antibacterial activities of an L-amino acid oxidase from king cobra (Ophiophagus hannah) venom
Some constituents of snake venom have been found to display a variety of biological activities. The antibacterial property of snake venom, in particular, has gathered increasing scientific interest due to antibiotic resistance. In the present study, king cobra venom was screened against three strains of Staphylococcus aureus [including methicillin-resistant
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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11. Caracterização bioquímica, estrutural e funcional de uma L-aminoácido oxidase isolada de peçonha de Lachesis muta (Serpentes, Viperidae) / Purification, biochemistry and functional characterization of a new L-amino acid oxidase from Lachesis muta venom.
As peçonhas de serpentes contêm uma mistura complexa de substâncias farmacologicamente ativas, como metaloproteases, fosfolipases A2, serino-proteases, L-aminoácido oxidase (LAAO), além de outros importantes compostos sem ação enzimática. LAAOs são flavoproteínas que catalisam a desaminação oxidativa de L-aminoácidos e produzem o -cetoácido cor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/10/2011
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12. Efeito do veneno bruto e da L-aminoácido oxidase de Bothrops pirajai em células BCR-ABL positivas / Effect of Bothrops pirajai crude venom and L-amino acid oxidase in BCR-ABL positive cells.
A leucemia mielóide crônica (LMC) é uma doença mieloproliferativa caracterizada citogeneticamente pela presença do cromossomo Philadelfia (Ph) e molecularmente pelo neogene bcr-abl1 que codifica a oncoproteína BCR-ABL com alta atividade de tirosina-quinase. A célula leucêmica BCR-ABL+ apresenta baixa adesão ao estroma medular, resistência à apopto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/07/2011