Insulin Secreting Cells
Mostrando 1-12 de 70 artigos, teses e dissertações.
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1. Vias de transdução de sinal do receptor tipo Toll 4 nas células pancreáticas e seus efeitos na secreção e produção de insulina / Toll-like receptor 4 signal transduction pathways in pancreatic cells and their effect on insulin secretion and production
INTRODUÇÃO: O receptor tipo Toll 4 (TLR4) pertencente a uma família de receptores do sistema imune inato, reconhece o padrão molecular de lipopolissacarídeos (LPS), expressos por bactérias Gram negativas. Sua cascata de sinalização, nas células apresentadoras de antígeno, ocorre por duas vias principais: MyD88-dependente, que resulta na ativação
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/08/2012
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2. AVALIAÇÃO DA CITOTOXICIDADE, CITOPROTEÇÃO E EFEITOS DOS FLAVONÓIDES RUTINA E HESPERIDINA SOBRE A FUNCIONALIDADE DE CÉLULAS SECRETORAS DE INSULINA BRIN-BD11
Diabetes mellitus is now a major public health problems, with increasing numbers of incidence, and has been considered an epidemic. Several studies demonstrate the relationship between diabetes mellitus and oxidative stress. Thus bioactive compounds with potential to act by preventing or mitigating the consequences of this process are interesting. In this ca
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/04/2011
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3. Análise in vitro da atividade antioxidante do suco e extrato de maçã em células RINm5f submetidas a diferentes condições de estresse oxidativo
The phenolic compounds, found in vegetables and fruits, may have a high antioxidant activity. Apple, worlds second largest produced fruit, is classified as having one of the high antioxidant potential due to its content and profile of phenolic compounds. The aim of this research was to evaluate the antioxidant activity of apple and check its effect on cells
Publicado em: 2009
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4. Mecanismos moleculares do efeito citotoxico da dexametasona em linhagens de celulas beta e ilhotas pancreaticas / Molecular mechanisms of the cytotoxic effect of dexamethasone in insulin producing cells and pancreatic islets
Introdução/Objetivos. A produção de espécies reativas de oxigênio (EROs) faz parte de diversos processos fisiológicos. Nos últimos anos, o aumento de EROs têm sido associado ao desenvolvimento de diversas doenças, dentre elas o Diabetes Mellitus Tipo 2. As células beta pancreáticas são notadamente mais suscetíveis ao estresse oxidativo devido a
Publicado em: 2009
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5. Identification of differentialy express genes during the differentiation of stem cells and characterization of mesenchymal progenitor cells / Identificação de genes diferencialmente expressos durante diferenciação de células-tronco e caracterização de células progenitoras mesenquimais
Diabetes mellitus (DM) defines a number of pathologies caused by the lack or deficient action of the insulin hormone. DM1 is caused by an auto-immune attack to insulin secreting β-pancreatic cells, while DM2 is related to ageing and obesity. Pancreas and islet allo-transplantation constitute therapeutic alternatives, but severe organ shortage and the ab
Publicado em: 2008
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6. Characterization of genes and serum proteins related to type 2 diabetes mellitus in patients treated with pioglitazone / Caracterização de genes e proteínas plasmáticas relacionadas ao diabetes melito do tipo 2 em indivíduos tratados com pioglitazona
The diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, the result from insulin secretion or action deficiency, or both. Pioglitazone is an oral hypoglycemic drug, included in the class of thiazolidinediones, which work by binding to nuclear receptors PPARY nuclear what improve the state of resistance to insulin. Pioglitazone m
Publicado em: 2008
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7. Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells.
Rat pancreatic AR42J cells possess exocrine and neuroendocrine properties. Activin A induces morphological changes and converts them into neuron-like cells. In activin-treated cells, mRNA for pancreatic polypeptide (PP) but not that for either insulin or glucagon was detected by reverse transcription-PCR. About 25% of the cells were stained by anti-PP antibo
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8. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1.
1. Whole-cell current-clamp recordings demonstrate that leptin (0.3-10 nm) hyperpolarizes CRI-G1 insulin-secreting cells. This effect is slow on onset and is not reversed on washout of the leptin. 2. Voltage-clamp recordings indicate that leptin activates a potassium conductance in the presence of intracellular ATP (5 mm), but has not effect in its absence.
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9. Mitochondrial Glutamate Carrier GC1 as a Newly Identified Player in the Control of Glucose-stimulated Insulin Secretion*
The SLC25 carrier family mediates solute transport across the inner mitochondrial membrane, a process that is still poorly characterized regarding both the mechanisms and proteins implicated. This study investigated mitochondrial glutamate carrier GC1 in insulin-secreting β-cells. GC1 was cloned from insulin-secreting cells, and sequence analysis revealed h
American Society for Biochemistry and Molecular Biology.
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10. Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells.
Calcium ions play a central role in stimulus-secretion coupling in pancreatic beta cells, and an elevation of cytosolic Ca2+ levels is necessary for insulin secretion. Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ stores in the beta cell by binding to specific receptors that are ligand-activated Ca2+ channels. The inositol trisphosphate receptors
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11. Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor
Macrophage migration inhibitory factor (MIF), originally identified as a cytokine secreted by T lymphocytes, was found recently to be both a pituitary hormone and a mediator released by immune cells in response to glucocorticoid stimulation. We report here that the insulin-secreting β cell of the islets of Langerhans expresses MIF and that its production is
The National Academy of Sciences of the USA.
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12. Inositol hexakisphosphate stimulates non-Ca2+-mediated and primes Ca2+-mediated exocytosis of insulin by activation of protein kinase C
d-myo-inositol 1,2,3,4,5,6-hexakisphosphate (InsP6), formed via complex pathways of inositol phosphate metabolism, composes the main bulk of inositol polyphosphates in the cell. Relatively little is known regarding possible biological functions for InsP6. We now show that InsP6 can modulate insulin exocytosis in permeabilized insulin-secreting cells. Concent
The National Academy of Sciences of the USA.