Hydrophilic Matrices
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
ABSTRACT Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit®
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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2. Adenanthera pavonina GALACTOMANNAN FOR CONTROLLED DELIVERY OF RUTIN - A PRELIMINARY STUDY
Improving the development of modified release matrix systems strictly depends on selecting an appropriate agent capable of controlling the drug's release. In this study, Adenanthera pavonina galactomannan was investigated as a potential basis for developing a controlled release of rutin. This galactomannan was extracted, purified and characterized by GPC, NM
Quím. Nova. Publicado em: 2018-06
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3. Applicability of FT-IR Techniques and Goniometry on Characterization of Carbon Fiber Surfaces
ABSTRACT Carbon fibers have been widely used as structural reinforcement in aeronautical composites, because of their exceptional mechanical properties. However, carbon fibers present few polar groups on their surfaces inducing a weak interaction with some thermosetting and thermoplastic matrices. Surface treatments, such as thermal and electrochemical oxida
J. Aerosp. Technol. Manag.. Publicado em: 2016-03
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4. Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol
This paper reports the development and validation of a new analytical method using UV spectrophotometry to quantify carvedilol (CRV) in hydrophilic matrices and raw material. This method was shown to be linear, accurate, precise, robust and to have adequate limits of quantification and detection (LQ and LD, respectively), allowing its use in the dissolution
Quím. Nova. Publicado em: 2013
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5. Desenvolvimento e validação de um método analítico simples e rápido por espectroscopia UV para quantificação de aciclovir em matrizes hidrofílicas de liberação prolongada
This work reports the validation of an analytical UV spectrophotometric method to assay acyclovir in hydrophilic matrices (assay and dissolution studies). The method was linear in the range between 2.5-20 µg mL-1, presenting a good correlation coefficient ( r = 0,9999). Precision and accuracy analysis showed low relative standart deviation (< 2.0 %) and a g
Química Nova. Publicado em: 2010
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6. Correlação in vitro in vivo para formas farmacêuticas sólidas de liberação modificada contendo diclofenaco de sódio / In vitro-in vivo correlation for sodium diclofenac modified release tablet formulations
The term in vitro-in vivo correlation (IVIVC) refers to the establishment of a rational relationship between the biological properties, or a parameter derived from a biological property produced by a dosage form, and a physicochemical characteristic or property of the same dosage form. The establishment of IVIVC enables the substitution of in vivo studies fo
Publicado em: 2009
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7. Use of raw material obtained from a renewable source in tbhe preparation of phenolic type matrix composites / Utilização de matéria-prima obtida de fonte renovável na preparação de compósitos de matriz tipo fenólica
In the present work phenolic type matrices were prepered, which were reinforced with lignocellullosic fibers (sisal). The tannin-phenolic and phenol-furfural resins, amid other techniques, were characterized by nuclear magnetic resonance (NMR). Model compounds were synthesized specially for the 1H and 13C NMR analysis of phenol-furfural resins. The sisal fib
Publicado em: 2008
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8. Estudo eletroquimico das caracteristicas trombogenicas de hidrogeis polimericos
Polymeric hydrogels to be used as hemo-compatible biomaterials, have been studied in relation to their biological, mechanical, physico-chemical and morphological properties, among others, but as far as is known no studies have treated their hemo-compatible characteristics from an electro-chemical perspective. In this work, previously oxidized low density pol
Publicado em: 2002
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9. Effect of microenvironment pH of swellable and erodable buffered matrices on the release characteristics of diclofenac sodium
The aim of this work is to design pH-dependent swellable and erodable-buffered matrices and to study the effect of the microenvironment pH on the release pattern of diclofenac sodium. Buffered matrix tablets containing diclofenac sodium, physically mixed with hydrophilic polymer (hydroxypropyl methylcellulose [HPMC]) and pH-dependent solubility polymer (Eudr
Springer-Verlag.
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10. Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride
The objective of this work was to develop matrix sustained-release tablets of highly water-soluble tramadol HCl using natural gums (xanthan [X gum] and guar [G gum]) as cost-effective, nontoxic, easily available, and suitable hydrophilic matrix systems compared with the extensively investigated hydrophilic matrices (ie, hydroxypropyl methylcellulose [HPMC]/c
Springer-Verlag.
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11. Estimation of the percolation thresholds in lobenzarit disodium native dextran matrix tablets
The objective of the present work is to estimate for the first time the percolation threshold of a new series of dextran (native dextran of high molecular weight [B110-1-2, Mw=2×106]), in matrices of lobenzarit disodium (LBD) and to apply the obtained result to the design of hydrophilic matrices for the controlled delivery of this drug. The formulations stu
Springer-Verlag.
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12. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved for the alignment of divergent protein sequences. Firstly, individual weights are assigned to each sequence in a partial alignment in order to down-weight near-duplicate sequences and up-weight the most divergent ones. Secondly, amino acid substituti