Gene Expression
Mostrando 13-24 de 39727 artigos, teses e dissertações.
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13. Antitumor activity of irinotecan with ellagic acid in C6 glioma cells
SUMMARY OBJECTIVE: Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cel
Revista da Associação Médica Brasileira. Publicado em: 2022
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14. Long non-coding RNA HOTAIR induces the PI3K/AKT/mTOR signaling pathway in breast cancer cells
SUMMARY OBJECTIVE: The phosphoinositide 3-kinase/protein kinase AKT/mammalian target of rapamycin signaling pathway is essential for proper cellular metabolism and cell growth. However, aberrant activation of this pathway has been linked to the progression and metastasis of breast cancer. Recently, the role of long non-coding RNAs in interfering with the ce
Revista da Associação Médica Brasileira. Publicado em: 2022
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15. Serum Long-Noncoding RNA H19 and β-Catenin as Biomarkers for Early Diagnosis of Colorectal Cancer in Egyptian Patients: A Case Control Study
Abstract Colorectal cancer (CRC) is the third most prevalent cancer and the second most common cause of cancer death; however, its early detection can improve the survival. Colonic polyps are considered one of the CRC's major risk factors. Throughout many biological processes and malignancies, the non-coding RNAs have essential functions. Certain long noncod
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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16. Glycemic and nonglycemic mechanisms of congenital malformations in hyperglycemic pregnancies: a narrative review
ABSTRACT Congenital malformations are more frequently found among children born to mothers with diabetes than in the background population. There are several complex mechanisms involved in the development of congenital malformations in the offspring of mothers with hyperglycemia, such as the overexpression of glucose transporters (GLUTs) 1 and 2, the increas
Archives of Endocrinology and Metabolism. Publicado em: 2022
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17. Artichoke for biochemistry, histology, and gene expression in obstructive jaundice
SUMMARY OBJECTIVE: This study aimed to evaluate the hepatoprotective effect of artichoke leaf extract (Cynara scolymus) in experimental obstructive jaundice. METHODS: Rats were separated into three groups, namely, sham, control, and artichoke leaf extract. Ischemia was created for 60 min, and then liver tissue and blood samples were taken at the 90th minut
Revista da Associação Médica Brasileira. Publicado em: 2022
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18. Innate immunity gene expression profiles in conjunctival membrane biopsies from Amazonian buffalo
RESUMO A produção de búfalos domésticos desempenha um papel economicamente importante na Amazônia brasileira, mas eles são suscetíveis a muitas doenças favorecidas pelo clima tropical e habitats inundados anualmente, incluindo doenças oculares. Nesse contexto, é importante selecionar genótipos que maximizem a imunidade ocular inata em rebanhos ama
Acta Amazonica. Publicado em: 2022
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19. The effect of Lacticaseibacillus casei on inflammatory cytokine (IL-8) gene expression induced by exposure to Shigella sonnei in Zebrafish (Danio rerio)
RESUMO Este estudo teve como objetivo avaliar a função protetora dos probióticos contra a patogenicidade Shigella sonnei. Para este fim, 400 zebrafish foram divididos em quatro grupos com duas réplicas: (T1): recebendo Lacticaseibacillus casei por 27 dias, (T2): recebendo L. casei por 27 dias seguido por 72 horas de exposição a S. sonnei, (T3): receben
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2022
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20. Downregulation of CSF-derived miRNAs miR-142-3p and miR-17-5p may be associated with post-dural puncture headache in pregnant women upon spinal anesthesia
Abstract Background: Postdural puncture headache (PDPH) develops due to puncture of the dura mater. The risk factors that influence PDPH incidence are Body Mass Index (BMI), sex, spinal needle type, history of headache, and loss of Cerebrospinal fluid (CSF) volume, yet there is no consensus on these risk factors. The pathophysiology of PDPH is poorly unders
Brazilian Journal of Anesthesiology. Publicado em: 2022
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21. COMBINING ABILITY AND GENE ACTION IN THE EXPRESSION TRAITS IN MAXIXE
RESUMO O maxixe (Cucumis anguria L.) é uma espécie de origem africana, pertencente à família das cucurbitáceas, muito cultivado no Brasil, porém com pouca informação sobre o controle gênico das características. Efeitos gênicos aditivos, refletidos nas estimativas dos efeitos de variedade ou desempenho “per se” é importante na expressão das c
Revista Caatinga. Publicado em: 2022
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22. Plant hormones accumulation and its relationship with symplastic peroxidases expression during carnation-Fusarium oxysporum interaction
Resumo A murcha vascular causada por Fusarium oxysporum f. sp. Dianthi (Fod) é a doença mais relevante para o cultivo de cravo. Compreender os mecanismos bioquímicos envolvidos na resistência ao Fod permitirá o desenvolvimento de novas estratégias de controle de doenças. Nesta pesquisa, os níveis de alguns fitohormônios como ácido salicílico (SA),
Ornamental Horticulture. Publicado em: 2022
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23. Subcutaneous tissue reaction and gene expression of inflammatory markers after Biodentine and MTA implantation
Resumo Objetivo: Avaliar a resposta do tecido conjuntivo subcutâneo de camundongos isogênicos expostos à Biodentine™ e ao Trióxido Mineral Agregado (MTA). Métodos: Um total de 120 camundongos foram divididos em 4 grupos e 3 períodos experimentais diferentes (7, 21 e 63 dias): Biodentine™ (Septodont, Saint Maur des Fosses, França); Pro-Root MTA (De
Brazilian Dental Journal. Publicado em: 2022
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24. The circadian timing of noise exposure influences noise-induced inflammatory responses in the mouse cochlea
Abstract Introduction: Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss. Nevertheless, the mechanisms of noise-induced hearing loss are still not fully understood. Objective: To investigate the dynamics of inflammatory responses in the mammalian cochlea following noise trauma at two different times, once during the l
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022