Gastric Simulated Fluid
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. Design and evaluation of rhubarb total free anthraquinones oral colon-specific drug delivery granules to improve the purgative effect
Rhubarb is commonly used as a cathartic in Asian countries. However, researchers have devotedextensive concerns to the quality control and safety of rhubarb and traditional Chinese preparations composed of rhubarb due to the instable purgative effect and potential nephrotoxicity of anthraquinones. In this study, we aimed to prepare rhubarb total free anthraq
Braz. J. Pharm. Sci.. Publicado em: 10/07/2019
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2. Screening and characterization of lactic acid bacterial strains that produce fermented milk and reduce cholesterol levels
ABSTRACT Objective To screen for and characterize lactic acid bacteria strains with the ability to produce fermented milk and reduce cholesterol levels. Methods The strains were isolated from traditional fermented milk in China. In vitro and in vivo evaluation of cholesterol-reduction were used to identify and verify strains of interest. Characteristics we
Braz. J. Microbiol.. Publicado em: 2017-12
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3. Anti-nutritional factors and digestibility of protein in Cayocar brasiliense seeds
Abstract The Brazilian Cerrado presents a wide variety of natural products, including the Pequi (Caryocar brasiliense). The important factor that determines the dietary and nutritional ideality of protein is degestitibility. This work aims to evaluate the protein digestibility of Pequi seeds and the presence of anti-nutritional factors. The protein Pequi alm
Food Sci. Technol. Publicado em: 26/10/2017
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4. Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes
ABSTRACT Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-glycosidase, lipase, and trypsin
An. Acad. Bras. Ciênc.. Publicado em: 29/06/2017
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5. Design and preparation of a novel colon-targeted tablet of hydrocortisone
ABSTRACT The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength,
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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6. Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying
Abstract Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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7. Metanolic extract of Malpighia emarginata bagasse: phenolic compounds and inhibitory potential on digestive enzymes
ABSTRACT Adding value to fruit residues is of great interest, since they can be presented as a viable solution in search of new drugs for the treatment of obesity and related diseases, due to bioactive substances, especially phenolic compounds. Thus, the objective of this study was to prepare the methanol extract of acerola bagasse flour, in order to evaluat
Rev. bras. farmacogn.. Publicado em: 2016-04
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8. Soy Protein Isolate-Alginate Microspheres for Encapsulation ofEnterococcus faecalis HZNU P2
ABSTRACTIn this work, the mixture of alginate and soy protein isolate used as a wall material was developed to encapsulateEnterococcus faecalis HZNU P2 (E. faecalis HZNU P2). The survival ability in the simulated gastric fluid (SGF) and bile salt solution, storage stability at different temperatures and release properties in the simulated intestinal fluid (S
Braz. arch. biol. technol.. Publicado em: 2015-10
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9. Activity of encapsulated Lactobacillus bulgaricus in alginate-whey protein microspheres
In this work, alginate-whey protein was used as wall materials for encapsulating Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus). The characteristics of encapsulated and free L. bulgaricus showed that the free L. bulgaricus lost viability after 1 min exposure to simulated gastric fluid (SGF) at pH 2.0 and 2.5. However, the viability of encapsulat
Braz. arch. biol. technol.. Publicado em: 2014-10
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10. Availability of ca, cu, fe, mg and zn in bovine, pork and chicken meat samples raw and termically processed / Determinação da disponibilidade de Ca, Cu, Fe, Mg e Zn em amostras de carnes bovinas, suínas e de frango In natura e processadas termicamente
In this work, the availability of Ca, Cu, Fe, Mg, and Zn in bovine, pork and chicken meat samples raw and after thermal treatments: water boiled, grilled, microwave, convention oven I 180 oC (FCI) and conventional oven II 60 min and 180 oC was evaluated. Total determination of Ca, Cu, Fe, Mg and Zn in bovine and pork samples was performed by inductively coup
Publicado em: 2010
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11. Sobrevivência em fluído gástrico simulado e capacidade de invasão intestinal de Salmonella enteridis e Salmonella typhimurium induzidas e não induzidas à adaptação ácida / Survival in simulated gastric fluid and ability to intestinal invasion of Salmonella Enteritidis and Salmonella Typhimurium induced and not induced to adapt acid
No Rio Grande do Sul, um grupo clonal de Salmonella Enteritidis vem sendo identificada como o principal microrganismo causador de Doenças Transmitidas por Alimentos (DTA) nos últimos anos. Em vista disso, o objetivo deste trabalho foi avaliar a sobrevivência em fluido gástrico simulado (FGS) e a capacidade de invasão intestinal de Salmonella Enteritidis
Publicado em: 2008
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12. Microparticulas de quitosana com didanosina e sua formulação em granulos mucoadesivos / Didanosine-load chitosan microspheres and their formulation in mucoadhesive granules
In this work a scalable process was developed for the production of gastroresistent granules containing chitosan microspheres, loaded with the drug didanosine (ddl). The global process included three stages, and the operational conditions were optimized in order to maintain the active form of the drug didanosine, which is sensitive to acidic pH conditions, a
Publicado em: 2006