Gaba B Receptors
Mostrando 1-12 de 35 artigos, teses e dissertações.
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1. Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors
ABSTRACT Feeding behavior is regulated via a complex network which interacts via diverse signals from central and peripheral tissues. Endocannabinoids modulate release of GABA in a variety of regions of the central nervous system. Endocannabinoids and GABAergic system have an important role in the central regulation of appetite. Thus, the present study exami
Rev. Bras. Cienc. Avic.. Publicado em: 2017-06
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2. Neural mechanisms involved in the delay of gastric emptying of liquids in rats induced by myocardial infarction recent / Mecanismos neurais envolvidos no retardo do esvaziamento gástrico de íiquidos em ratos induzido através do infarto recente do miocardio
O esvaziamento gástrico (EG) consiste na transferência ordenada do conteúdo do estômago para o duodeno, Situações patológicas como alterações hemodinâmicas modificam a velocidade do E.G. e função motora do trato gastrointestinal. O infarto do miocárdio determina retarde do E.G. em ratos, possivelmente pelo estresse causado pela ligadura da arté
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/05/2012
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3. Synthesis and biological activity of allosteric modulators of GABA B receptors part 3. 3-(2,6-bis-iso-propyl-4-hydroxyphenyl)propanols
Uma série de seis derivados do propan-1-ol 2,2-disubistituído 3-[3,5-di-iso-propil-4-hydroxifenil] foi preparada para avaliação como moduladores alostéricos de receptores GABA B. A maior atividade (EC50 30 µM) encontrada na série foi para os análogos do dimetil, mas os compostos isopropilfenil foram, de maneira geral, mais fracos que os compostos t-b
Journal of the Brazilian Chemical Society. Publicado em: 2007
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4. Effect of antipyrine on the gastric emptying of liquid in rats
Antipyrine (At) and dipyrone (Dp) delay gastric emptying (GE) in rats. The objective of the present study was to assess the effects of intravenous (iv) and intracerebroventricular (icv) administration of At and Dp on the GE of liquid by rats. GE was assessed in male Wistar rats (5-10 in each group) 10 min after the icv or iv drug injection by measuring perce
Brazilian Journal of Medical and Biological Research. Publicado em: 22/09/2006
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5. The bradycardic and hypotensive responses to serotonin are reduced by activation of GABA A receptors in the nucleus tractus solitarius of awake rats
We investigated the effects of bilateral injections of the GABA receptor agonists muscimol (GABA A) and baclofen (GABA B) into the nucleus tractus solitarius (NTS) on the bradycardia and hypotension induced by iv serotonin injections (5-HT, 2 µg/rat) in awake male Holtzman rats. 5-HT was injected in rats with stainless steel cannulas implanted bilaterally i
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-07
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6. Effect of the GABA B agonist baclofen on dipyrone-induced delayed gastric emptying in rats
Dipyrone administered intravenously (iv) or intracerebroventricularly (icv) delays gastric emptying (GE) in rats. Gamma-aminobutyric acid (GABA) is the most potent inhibitory neurotransmitter of the central nervous system. The objective of the present study was to determine the effect of icv baclofen, a GABA B receptor agonist, on delayed GE induced by dipyr
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-01
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7. Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors.
Despite considerable evidence that ethanol can enhance chloride flux through the gamma-aminobutyric acid type A (GABA/A/) receptor-channel complex in several central neuron types, the effect of ethanol on hippocampal GABAergic systems is still controversial. Therefore, we have reevaluated this interaction in hippocampal pyramidal neurons subjected to local m
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8. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes
Cell membranes isolated from brain tissues, obtained surgically from six patients afflicted with drug-resistant temporal lobe epilepsy and from one nonepileptic patient afflicted with a cerebral oligodendroglioma, were injected into frog oocytes. By using this approach, the oocytes acquire human GABAA receptors, and we have shown previously that the “epile
National Academy of Sciences.
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9. Ligand-induced signal transduction within heterodimeric GABAB receptor
γ-aminobutyric acid type B (GABAB) receptors, G protein-coupled receptors (GPCRs) for GABA, are obligate heterodimers of two homologous subunits, GB1 and GB2. Typical for family C GPCRs, the N termini of both GB1 and GB2 contain a domain with homology to bacterial periplasmic amino acid-binding proteins (PBPs), but only the GB1 PBP-like domain binds GA
The National Academy of Sciences.
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10. Proton sensitivity of the GABA(A) receptor is associated with the receptor subunit composition.
1. Modulation of GABA(A) receptors by external H(+) was examined in cultured rat sympathetic neurones, and in Xenopus laevis oocytes and human embryonic kidney (HEK) cells expressing recombinant GABA(A) receptors composed of combinations of alpha 1, beta 1, beta 2, gamma 2S and delta subunits. 2. Changing the external pH from 7.4 reduced GABA-activated curre
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11. Pharmacological evidence for two kinds of GABA receptors on rat hippocampal pyramidal cells studied in vitro
1. The rat hippocampal slice preparation has been used in conjunction with intracellular recording and ionophoresis to study the action of γ-aminobutyric acid (GABA) on CA1 pyramidal cells.
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12. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors
The principal inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid (GABA), is thought to regulate memory processes by activating transient inhibitory postsynaptic currents. Here we describe a nonsynaptic, tonic form of inhibition in mouse CA1 pyramidal neurons that is generated by a distinct subpopulation of GABA type A receptors (GABAARs
National Academy of Sciences.