Enzymatic Activity
Mostrando 1-12 de 3840 artigos, teses e dissertações.
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1. CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, this molecule is a relevant candidate for drug development, but there is still no information on its human metabolism and systemic eliminat
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Synthesis and SARS-CoV-2 3CL Protease Inhibitory Effects of Oxazolidinone Derivatives
The 3-chymotrypsin-like protease (3CLpro) is an attractive target for the development of anti-SARS (severe acute respiratory syndrome) drugs. In this work, a series of oxazolidinone derivatives 3a-3v were synthesized and their inhibitory activities against SARS coronavirus 2 (SARS-CoV-2) 3CLpro were evaluated by the fluorescence resonance energy transfer (FR
Journal of the Brazilian Chemical Society. Publicado em: 2022
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3. Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation
Considering the promising antitumor effects of compounds with dual anti-inflammatory and antiproliferative activities, thus benzophenones analogs (2-7) were evaluated on in vivo anti-inflammatory assay and molecular docking analysis. Those with the best molecular docking results were in vitro evaluated on cyclooxygenase (COX) enzymes and tested regarding ant
Journal of the Brazilian Chemical Society. Publicado em: 2022
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4. Enzymatic efficiency of the decomposing microbiota: what does really matter for aquatic macrophytes invasions?
ABSTRACT Biological invasions have negative impacts on different ecosystem-level functions, such as nutrient cycling. In aquatic environments, exotic litter can change the activity of the decomposer microbiota. We tested whether litter quality, litter decay, and enzyme activity differed between nativeEgeria densaand exoticHydrilla verticillata. The invasive
Acta Bot. Bras.. Publicado em: 2021-03
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5. Inhibition of Acetylcholinesterase by Coumarin-Linked Amino Acids Synthetized via Triazole Associated with Molecule Partition Coefficient
A previous study for the identification of acetylcholinesterase (AChE) inhibitors demonstrated that the hybrid between tyrosol, the 1,2,3-triazole nucleus, and the coumarin group, namely 7-({1-[2-(4-hydroxyphenyl)ethyl]-1H-1,2,3-triazol-4-yl}methoxy)-4-methyl-2H-chromen-2-one (10), has a high enzyme inhibitory activity. Here, we synthesized analogues of 10 v
J. Braz. Chem. Soc.. Publicado em: 2021-03
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6. Conservation system improves soil microbial quality and increases soybean yield in the Northeastern Cerrado
ABSTRACT The conservation tillage systems is based on the surface protection by crop residue and reduced soil disturbance. These two principles can favor the soil quality and promote sustainable agricultural systems. The study was developed with the objective of measure soil microbial biomass, soil basal respiration, enzymatic activity and soybean yield in c
Bragantia. Publicado em: 2020-12
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7. A Simple Approach to Analyze Sugar Nectar Composition in Flowers Using Capillary Electrophoresis and Enzymatic Assays
Despite the obvious importance of nectar, the composition of this solution remains surprisingly understudied to most of the flowers. Here we describe a simple, low-cost, and reliable methodology to analyze the three main sugars present in 210 nectar samples of Christmas Bellflowers using capillary electrophoresis (CE) and enzymatic assays. CE separation (-16
J. Braz. Chem. Soc.. Publicado em: 2020-10
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8. Cocoa Agro-Industrial Residue (Theobroma cacao) as Inducer of the Production of Fungal Laccase and Kojic Acid for Application in the Biodegradation of 17-α-Ethinylestradiol
Due to the ability to catalyze the oxidation of several substrates, the enzyme laccase has been used in several applications, among them the bioremediation of emerging pollutants. This work evaluate the capacity of the cocoa agro-industrial residue to induce the production of Pycnoporus sanguineus laccase and to apply the enzymatic extract in the biodegradat
J. Braz. Chem. Soc.. Publicado em: 2020-10
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9. Comparative analysis of enzymatic activity of tannase in non-conventional yeasts to produce ellagic acid
Abstract Non-conventional yeasts represent an alternative for microorganisms that are capable to produce the enzyme Tannase (EC 3.1.1.20), which has many applications is the food and pharmaceutical industry as it stands out for its ability to produce ellagic acid out of the enzymatic hydrolysis of ellagitannins. Ellagic acid has been studied in the medical a
Food Sci. Technol. Publicado em: 2020-09
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10. Carcinoma prostático com metástase para seios frontal e cavernoso: relato de caso
Abstract One of the major problems affecting potatoes quality on stored is the susceptibility to enzymatic browning, which occurs mainly after wounds during the harvest, at postharvest handling and by aging, leading to the development of dark color compounds. Enzymatic browning is associated with the action of polyphenoloxidases (PPO) and peroxidases (POD),
Braz. j. otorhinolaryngol.. Publicado em: 2020-06
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11. Activity of polyphenoloxidase and peroxidase in non-dormant potato tubers treated with sprout suppressors
Abstract One of the major problems affecting potatoes quality on stored is the susceptibility to enzymatic browning, which occurs mainly after wounds during the harvest, at postharvest handling and by aging, leading to the development of dark color compounds. Enzymatic browning is associated with the action of polyphenoloxidases (PPO) and peroxidases (POD),
Food Sci. Technol. Publicado em: 2020-06
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12. Avocado oil as an inducer of the extracellular lipase activity of Kluyveromyces marxianus L-2029
Abstract Avocado represents one of the most nutritious and consumed foods in Mexico, and its export generates significant profits; because of its fatty acids content, the avocado oil was used as an inducer for the synthesis of extracellular lipases from the non-conventional yeast Kluyveromyces marxianus L-2029. Lipases are able to catalyze acyl glycerides, h
Food Sci. Technol. Publicado em: 2020-06