Dissolution
Mostrando 13-24 de 951 artigos, teses e dissertações.
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13. PARTICLE SIZE DISTRIBUTION APPLIED TO MILK POWDER REHYDRATION
Besides increasing shelf life of fluid milk, milk powder has physical and functional properties that allow it to be used as ingredient. The rehydration process is complex and happens in four steps: wettability, sinkability, dispersibility and solubility. Works have been conducted aiming at the development of an easier, more convenient and reproducible method
Quím. Nova. Publicado em: 2020-02
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14. Characterization and Comparative Analysis of Corrosion Resistance of 4 High Manganese Steels Models in Aqueous Solution of NaCl
The liquefied natural gas volumes that currently need to be stored and/or transported require engineering to consistently develop materials that combine high mechanical strength and low manufacturing costs. The present work brings the study of four models of high manganese steels (non-commercials), to demonstrate the feasibility of being used in the petroche
Mat. Res.. Publicado em: 09/12/2019
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15. Silymarin-Laden PVP-Nanocontainers Prepared Via the Electrospraying Technique for Improved Aqueous Solubility and Dissolution Rate
Abstract The aim of the present research was to develop a silymarin-laden PVP-nanocontainer providing ameliorated aqueous solubility and dissolution of the drug. Several silymarin-laden formulations were formed with varying quantities of PVP and SDS via the solvent evaporation method using the electrospraying technique. The influence of the hydrophilic carri
Braz. arch. biol. technol.. Publicado em: 28/11/2019
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16. Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles
Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins (β-cyclodextrin and hydroxypropyl-β-cyclodextrin) in both water and an aqueous solution of polyvinylpyr
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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17. In vitro characterization and in vivo performance of mefenamic acid-sodium diethyldithiocarbamate based liposomes
Mefenamic acid (MFA) is a hydrophobic drug with low dissolution rate. This study aimed to develop stable and reproducible aqueous formulations of MFA using liposomes as drug carriers. The drug entrapment, particles size and drug release profiles, and stability and reproducibility of the liposomes were determined. In addition, the maximum tolerated dose (MTD)
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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18. Developing a Mathematical Model for the Controlled Release Over Time of Sulfentrazone Herbicide from Biodegradable Polymer
In our research group, controlled release systems for the sulfentrazone herbicide has been accomplished by encapsulating this bioactive compound into calcium alginate (Ca-ALG) biodegradable polymer fashion and the release mechanisms were verified by using Korsmeyer-Peppas model (KP). However, the KP model does not allow to evaluate all the phenomena involved
Mat. Res.. Publicado em: 11/11/2019
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19. How much do we know about the groundwater quality and its impact on Brazilian society today?
Resumo As águas subterrâneas são um recurso imprescindível para a sociedade e o meio ambiente no Brasil. Mais de 557 m3/s (17.5 km3/a) são extraídos através de 2.5 milhões de poços para atender a demanda nas cidades e no campo, gerando uma economia de R$ 56 bilhões ao ano (US$ 14 bilhões/ano). O aquífero tem função impar no ciclo hidrológico,
Acta Limnol. Bras.. Publicado em: 04/11/2019
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20. Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies
The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and optimized by the micromeritic properties including flowab
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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21. Preparation and evaluation of 2-methoxyestradiol-loaded pH-sensitive liposomes
The development and clinical application of 2-methoxyestradiol (2-ME) as a new type of antitumor drug are limited due to its poor solubility, rapid metabolism in vivo, and large oral dosage. 2-ME-loaded pH-sensitive liposomes (2-ME-PSLs) was prepared containing the lipids, Lipoid E-80 (E-80), cholesteryl hemisuccinate (CHEMS), and cholesterol (CHOL) via thin
Braz. J. Pharm. Sci.. Publicado em: 03/10/2019
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22. CONTROLLED RELEASE OF THEOPHYLLINE-CHITOSAN COMPOSITE PARTICLES PREPARED USING SUPERCRITICAL ASSISTED ATOMIZATION
Abstract This study investigated the formation of composite particles of chitosan (CS) and theophylline (TPH) via supercritical assisted atomization (SAA) using aqueous ethanol (50%, v/v) as the solvent and supercritical CO2 as the spraying medium. According to XRD, DSC, and FTIR analyses, the crystal form of the SAA-treated TPH from the as-received TPH was
Braz. J. Chem. Eng.. Publicado em: 30/09/2019
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23. EFFECT OF Acidithiobacillus thiooxidans-CYSTEINE INTERACTIONS ON PYRITE BIOOXIDATION BY Acidithiobacillus ferrooxidans IN THE PRESENCE OF COAL COMPOUNDS
Abstract This study evaluated the biooxidation of pyrite contained in a Colombian coal (2.38 mm < particle size < 0.50 mm). The variables were cysteine concentration (0-600 mg/L) and culture type (pure Acidithiobacillus ferrooxidans (ATCC 23270) and a consortium of Acidithiobacillus thiooxidans (ATCC 15494) and Acidithiobacillus ferrooxidans). Pyrite oxidati
Braz. J. Chem. Eng.. Publicado em: 30/09/2019
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24. STABILITY AND TOXICITY PROFILE OF SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS (SEDS) FORMULATED Andrographis paniculata EXTRACT
Abstract The main objective was to evaluate the stability and toxicity of a Solution Enhanced Dispersion by Supercritical Fluids (SEDS) formulated A. paniculata extract that was intended for food applications. The best formulated SEDS A. paniculata extract with improved dissolution of andrographolide (data not shown) was obtained using 25 mg/mL A. paniculata
Braz. J. Chem. Eng.. Publicado em: 30/09/2019