Diethylnitrosamine
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice
Resumo O objetivo principal do presente estudo foi investigar as atividades quimiopreventiva e quimioterápica do extrato de Artemisia vulgaris em hepatocarcinogênese induzida por dietilnitrosoamina (DEN) em camundongos Balb C. Dietilnitrosoamina (DEN: 0,9%) foi preparada para induzir hepatocarcinoma em camundongos da linhagem Balb C. O extrato de A. vulgar
Braz. J. Biol.. Publicado em: 04/11/2019
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2. 18F-FDG PET/CT AS AN ASSESSMENT TOOL OF HEPATOCELLULAR CARCINOMA SECONDARY TO NON-ALCOHOLIC FATTY LIVER DISEASE DEVELOPMENT IN EXPERIMENTAL MODEL
RESUMO BACKGROUND: O carcinoma hepatocelular (CHC) pode ser a última fase da doença hepática gordurosa não alcoólica (DHGNA). Modelos experimentais são cruciais para elucidação da patogênese do CHC secundário a DHGNA. A tomografia por emissão de pósitrons/tomografia computadorizada (PET/TC) com 2-desoxi-2-(18F)fluoro-D-glicose (18F-FDG) desempe
Arq. Gastroenterol.. Publicado em: 18/03/2019
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3. Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model
Liver fibrosis occurring as an outcome of non-alcoholic steatohepatitis (NASH) can precede the development of cirrhosis. We investigated the effects of sorafenib in preventing liver fibrosis in a rodent model of NASH. Adult Sprague-Dawley rats were fed a choline-deficient high-fat diet and exposed to diethylnitrosamine for 6 weeks. The NASH group (n=10) rece
Braz J Med Biol Res. Publicado em: 24/02/2015
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4. Sewage sludge does not induce genotoxicity and carcinogenesis
Through a series of experiments, the genotoxic/mutagenic and carcinogenic potential of sewage sludge was assessed. Male Wistar rats were randomly assigned to four groups: Group 1 - negative control; Group 2 - liver carcinogenesis initiated by diethylnitrosamine (DEN; 200 mg/kg i.p.); Group 3 and G4- liver carcinogenesis initiated by DEN and fed 10,000 ppm or
Genetics and Molecular Biology. Publicado em: 02/08/2012
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5. Avaliação do potencial genotóxico e cancerígeno do lodo de estação de tratamento de esgoto (LETE) em sistemas experimentais in vivo / In vivo evaluation of the carcinogenic potential of sewage sludge from a urban wastewater treatment plant in experimental systems
A rápida oxidação da matéria orgânica dos solos tropicais é mais uma evidência da grande vantagem do uso de biossólidos como condicionadores, capazes de melhorar as características físicas, químicas e biológicas do solo com grandes reflexos na produtividade agrícola. Portanto, o presente projeto objetivou averiguar o potencial genotóxico e canc
Publicado em: 2009
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6. Paullinia cupana Mart var. sorbilis, guaraná, reduces cell proliferation and increases apoptosis of B16/F10 melanoma lung metastases in mice
We showed that guaraná (Paullinia cupana Mart var. sorbilis) had a chemopreventive effect on mouse hepatocarcinogenesis and reduced diethylnitrosamine-induced DNA damage. In the present experiment, we evaluated the effects of guaraná in an experimental metastasis model. Cultured B16/F10 melanoma cells (5 x 10(5) cells/animal) were injected into the tail ve
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-04
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7. Atividade quimiopreventiva do farnesol e geraniol em ratos Wistar submetidos ao modelo de hepatocarcinogênese do hepatócito resistente" / Farnesol and gernariol chemopreventive activity in Wistar rats submitted to the "resistant hepatocyte"model of hepatocarcinogenesis
In the present study, the chemopreventive activity of farnesol (FR) and geraniol (GR), isoprenoids present in fruits and herbs, was evaluated when administered to Wistar rats during the initiation and/or selection/promotion phases of the "resistant hepatocyte" (RH) model of hepatocarcinogenesis. In Experimental Protocol 1, animals received during 8 consecuti
Publicado em: 2004
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8. Pré-concentração de nitrosaminas a partir de amostras aquosas por extração em fase sólida e cromatografia capilar eletrocinética micelar
This paper describes the development of a methodology for solid phase extraction (SPE) and pre-concentration of nitrosamines from aqueous samples using granular activated charcoal as stationary phase. micelar electrokinetic capillary Chromatography (MEKC) was used for the separation and identification of the nitrosamines in the extracts. Using a sample with
Química Nova. Publicado em: 2003-03
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9. Avaliação do efeito inibidor da vitamina C na carcinogenese esofagica experimental induzida pela dietilnitrosamina
Cancer is today the second death cause in developed countries. In spite of the fact that certain advances have been obtained in the course of its treatment, the prognosis of this disease is still far from being satisfactory. Although esophageal cancer is not among the most frequent kinds of cancer actually it is the fourth neoplasia to affect man s digestive
Publicado em: 1998
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10. Lung endocrine-like cells in hamsters treated with diethylnitrosamine: alterations in vivo and in cell culture.
Diethylnitrosamine is known to cause squamous cell carcinoma and adenocarcinoma of the lung in Syrian golden hamsters. Sections of lungs obtained from hamsters treated with the systemic carcinogen diethylnitrosamine showed a significant increase in the number of argyrophilic cells of neuroepithelial bodies. The hyperplastic response was retained at least 4 w
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11. Induction of Mitotic Crossing over in SACCHAROMYCES CEREVISIAE by Breakdown Products of Dimethylnitrosamine, Diethylnitrosamine, 1-Naphthylamine and 2-Naphthylamine Formed by an IN VITRO Hydroxylation System
Dimethylnitrosamine and diethylnitrosamine, two potent carcinogens, are nonmutagenic when tested directly in microorganisms. Likewise 1-naphthylamine and 2-naphthylamine are also nonmutagenic but the N-hydroxy derivatives are mutagenic in microorganisms. Apparently these compounds require metabolism to breakdown products which are then the proximately active
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12. A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.
Major histocompatibility complex (MHC)-linked deletions in the rat are associated with defects in growth and development and increased susceptibility to chemical carcinogens. The present study maps a locus critical for determining susceptibility to diethylnitrosamine (DEN) carcinogenesis by using two groups of MHC-recombinant rats congenic for the MHC and it