Deafness Physiology
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Estudo molecular de genes envolvidos em disturbios de queratinização e perda auditiva / Molecualr study in keratinization disturb and hearing loss genes
Nos organismos superiores, a comunicação entre as células ocorre através de proteínas denominadas conexinas, implicadas na comunicação intercelular (gap junction), as quais permitem a transferência direta de pequenas moléculas e íons. Na pele desempenham um papel crucial na sinalização e diferenciação epidérmica. Na cóclea as gap junctions ex
Publicado em: 2008
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2. Deafness and Cochlear Fibrocyte Alterations in Mice Deficient for the Inner Ear Protein Otospiralin
In the cochlea, the mammalian auditory organ, fibrocytes of the mesenchymal nonsensory regions play important roles in cochlear physiology, including the maintenance of ionic and hydric components in the endolymph. Occurrence of human deafness in fibrocyte alterations underlines their critical roles in auditory function. We recently described a novel gene, O
American Society for Microbiology.
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3. Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice
Deafness in spontaneously occurring mouse mutants is often associated with defects in cochlea sensory hair cells, opening an avenue to systematically identify genes critical for hair cell structure and function. The classical semidominant mouse mutant varitint-waddler (Va) exhibits early-onset hearing loss, vestibular defects, pigmentation abnormalities, and
National Academy of Sciences.
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4. TRPMLs: in sickness and in health
TRPML1, TRPML2 and TRPML3 belong to the mucolipin family of the TRP superfamily of ion channels. The founding member of this family, TRPML1, was cloned during the search for the genetic determinants of the lysosomal storage disease mucolipidosis type IV (MLIV). Mucolipins are predominantly expressed within the endocytic pathway, where they appear to regulate
American Physiological Society.