Coagulation Protein Disorders
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Age-related biological activity of South American rattlesnake (Crotalus durissus terrificus) venom
An in vitro and in vivo comparative study was performed on the effects of Crotalus durissus terrificus venoms from a mother and its 15 newborns. The venoms were tested for protein content, lethality, proteolytic, myotoxic, hemorrhagic, and phospholipase A2 activity. The minimum coagulant dose in plasma and human fibrinogen, protrhombin, and Factor II activat
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2003
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2. Estudo de componentes da hemostasia em crianças portadoras de trombose da veia porta
Althoug venous thrombosis is rare in childhood, yet it is morbid and sometÍI!l~s fatal. Some factors such as infections, congenital anomalies, umbilical catheterism and genetical coagulation disorders have been linked to portal vein thrombosis (TVP). Hemostasis disorders have not been studied deeply and ve:ry few data is available. Having in mind to researc
Publicado em: 1996
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3. Blood coagulation and its alterations in hemorrhagic and thrombotic disorders.
Clinical observations have added to the understanding of basic mechanisms of blood coagulation and its alterations in certain hemorrhagic and thrombotic states. Much clinical evidence exists for concluding that the exposure of blood to tissue factor (thromboplastin) on tissue cells represents the key event initiating fibrin clot formation after tissue injury
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4. Protein C deficiency: summary of the 1995 database update.
The coagulation cascade is controlled by several anticoagulant safeguards that avoid excessive clot formation. Disorders of these anticoagulant mechanisms are an important health problem, as they lead to increased risk of thromboembolism. Protein C deficiency is probably the most extensively studied abnormality in natural anticoagulants. Under the auspices o
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5. Protective mechanisms of activated protein C in severe inflammatory disorders
The protein C system is an important natural anticoagulant mechanism mediated by activated protein C (APC) that regulates the activity of factors VIIIa and Va. Besides well-defined anticoagulant properties, APC also demonstrates anti-inflammatory, anti-apoptotic and endothelial barrier-stabilizing effects that are collectively referred to as the cytoprotecti
Blackwell Publishing Ltd.
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6. Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII
Hemophilia is a bleeding disorder caused by mutations in the genes encoding coagulation Factor VIII (FVIII) or FIX. Current treatment is through intravenous infusion of the missing protein. The major complication of treatment is the development of neutralizing Ab’s to the clotting factor. Infusion of recombinant activated human Factor VII (rhFVIIa), drivin
American Society for Clinical Investigation.
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7. Manipulation of the membrane binding site of vitamin K-dependent proteins: Enhanced biological function of human factor VII
Recent studies suggested that modification of the membrane contact site of vitamin K-dependent proteins may enhance the membrane affinity and function of members of this protein family. The properties of a factor VII mutant, factor VII-Q10E32, relative to wild-type factor VII (VII, containing P10K32), have been compared. Membrane affinity of VII-Q10E32 was a
The National Academy of Sciences.