Cathepsin L
Mostrando 1-12 de 121 artigos, teses e dissertações.
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1. New Synthetic Quinolines as Cathepsin K Inhibitors
Cathepsin K is a papain-like cysteine protease and is responsible for collagen degradation in bone tissue and thus represents an important target for the development of new therapies for treating diseases such as osteoporosis. Quinolines are an important class of heterocyclic molecular leads with a great pharmacological potential and represent a relevant sca
J. Braz. Chem. Soc.. Publicado em: 2020-08
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2. New cathepsin V inhibitor from stems of Bowdichia virgilioides
Abstract Bioassay-guided fractionation of Bowdichia virgilioides Kunth, Fabaceae, extracts has led to the isolation of cathepsin V inhibitors. The investigation of the hexane and ethyl acetate extracts allowed the characterization of eleven compounds: lupeol, lupenone, β-sitosterol and stigmasterol in mixture, trans p-coumaric acid ester derivative, syringa
Rev. bras. farmacogn.. Publicado em: 17/10/2019
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3. ALCALOIDES ACRIDÔNICOS INIBEM CATEPSINA L E V
Cathepsins represent a class of enzymes that has the primary function of randomly degrading proteins in the lysosomes, although are also involved in different pathologies. The aim of this paper was to evaluate the capacity of acridone alkaloids isolated from Swinglea glutinosa (Rutaceae) to inhibit cathepsin L in vitro . The IC50 values found were in the 0.8
Quím. Nova. Publicado em: 2016-01
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4. Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver
It has been previously shown that dextran sulfate administered to diabetic rats accumulates in the liver and kidney, and this could be due to a malfunction of the lysosomal digestive pathway. The aim of the present study was to evaluate the expression and activities of lysosomal enzymes that act upon proteins and sulfated polysaccharides in the livers of dia
Braz J Med Biol Res. Publicado em: 2014-06
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5. Diagnóstico, caracterização molecular e epidemiologia de Trypanosamas de ungulados. / Diagnosis, molecular characterization and epidemiology of Trypanosame of ungulates.
Trypanosamas de diversas espécies podem infectar mamíferos de interesse econômico em todo o mundo. Trypanosoma vivax, T. evansi, T. equiperdum, T. congolense, T. b. brucei e T. simiae geram importantes doenças em ungulados na África, Ásia e Américas Central e do Sul; enquanto T. theileri e espécies relacionadas são pouco patogênicas. Compreender a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/05/2012
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6. Vias de sobrevivência e morte em queratinócitos submetidos ao estresse oxidativo e choque hiperosmótico / Survival and death signaling pathways in keratinocytes exposed to oxidative stress and hyperosmotic shock
The epidermis is constantly confronted with multiple environmental stressors. Changes in humidity or exposition to UV radiation affect the redox state and osmotic balance, modifying the physiological characteristics of the skin. In response to different stresses, epidermal keratinocytes can activate distinct signaling pathways and the balance between death a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2011
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7. Study of natural products and synthetic derivatives searching specific inhibitors of cathepsins L and V / Estudo de produtos naturais e derivados sintéticos buscando inibidores seletivos das catepsinas L e V
The present work describes the search of bioactive secondary metabolites in plant species of genus Zanthoxylum and synthetic derivatives seeking specific inhibitors of cathepsins L and V. The natural products are involved in approximately 50% of all drugs marketed. Cathepsins represent a class of enzymes that has the primary function of randomly degrade prot
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/01/2011
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8. Caracterização de proteinases envolvidas na geração de peptídeos antimicrobianos no intestino de Rhipicephalus (Boophilus) microplus. / CE. Characterization of proteinases involved in the generation of antimicrobial peptides in the gut of Rhipicephalus (Boophilus) microplus.
It is known that hemoglobin is a rich source of antimicrobial peptides (hemocidins). The first hemoglobin-derived hemocidin characterized in ticks was the peptide Hb33-61, which is active against Gram-positive bacteria and fungi. It is believed that hemocidins are endogenously generated in the tick gut. In this work we biochemically characterized a cathepsin
Publicado em: 2010
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9. Degradação de vitelina e hemoglobina no carrapato bovino Rhipicephalus (Boophilus) microplus
O presente trabalho caracterizou alguns aspectos enzimáticos da digestão de vitelina e de hemoglobina no carrapato bovino Rhipicephalus (Boophilus) microplus. Um novo protocolo foi desenvolvido para a purificação de uma cisteíno endopeptidase de larvas do carrapato (R. microplus Larval Cysteine Endopeptidase; RmLCE). A seqüência parcial de aminoácido
Publicado em: 2010
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10. Expression of schistosomal cathepsin l1 in Escherichia coli and evaluation of its protective capacity in an animal challenge
Schistosomes utilize proteinases to accomplish several activities such as tissue penetration, tissue digestion and evasion of host immune responses. Cathepsin L is a cysteine proteinase of the papain superfamily detected in their gut lumen which indicates that this enzyme contributes to the proteolysis of ingested hemoglobin. Due to the roles played in the s
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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11. Genes de cisteíno proteases (Catepsina L-like) de Trypanosoma rangeli: polimorfismo, relações filogenéticas e alvos para diagnóstico e genotipagem. / Cathepsin L-like genes of Trypanosoma rangeli: phylogenetic analysis and polymorphic sequences as markers for lineage genotyping and diagnosis.
Nós isolamos e seqüenciamos genes que codificam Catepsina L-like em diversos isolados de T.rangeli de humano, mamíferos silvestres e Rhodnius spp., do centro e sul da América. Análises filogenéticas de seqüências que codificam a proteína madura de T. rangeli, outras espécies de Trypanosoma e Leishmania e duas espécies de bodonídeos, posicionaram
Publicado em: 2009
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12. Estrutura e função das cisteína proteinases intestinais do besouro Tenebrio molitor / Structure and function of intestinais cysteine proteinases of Tenebrio molitor beetle
A catepsina L é uma cisteína proteinase da família da papaína (clã CA, família C1), sendo esta família a mais conhecida entre as cisteína proteinase. A catepsina L, como outras proteinases da família C1, é sintetizada como uma pró-enzima inativa que é ativada através da remoção do pró-peptídeo. Os pró-peptídeos das catepsinas da subfamíli
Publicado em: 2009