Cardiac Myocytes
Mostrando 1-12 de 588 artigos, teses e dissertações.
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1. New insight on the relationship between lethal electrical fields versus cardiomyocyte orientation
Abstract Introduction Cardiovascular diseases represent a major cause of death world-wide and one of their greatest complications is the development of cardiac arrhythmias, in which ventricular fibrillation (VF) stands out as the most severe one. The only therapy that reverses VF is defibrillation. However defibrillatory shock is capable of killing heart c
Res. Biomed. Eng.. Publicado em: 13/09/2018
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2. Early neonatal echocardiographic findings in an experimental rabbit model of congenital diaphragmatic hernia
This study aimed to demonstrate that congenital diaphragmatic hernia (CDH) results in vascular abnormalities that are directly associated with the severity of pulmonary hypoplasia and hypertension. These events increase right ventricle (RV) afterload and may adversely affect disease management and patient survival. Our objective was to investigate cardiac fu
Braz J Med Biol Res. Publicado em: 03/02/2015
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3. Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells
Macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, plays an important role in the pathogenesis of atrial fibrillation; however, the upstream regulation of MIF in atrial myocytes remains unclear. In the present study, we investigated whether and how MIF is regulated in response to the renin-angiotensin system and oxidative stress in atrium
Braz J Med Biol Res. Publicado em: 06/09/2013
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4. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats
OBJECTIVES: The present study was performed to investigate 1) whether aerobic exercise training prior to myocardial infarction would prevent cardiac dysfunction and structural deterioration and 2) whether the potential cardiac benefits of aerobic exercise training would be associated with preserved morphological and contractile properties of cardiomyocytes
Clinics. Publicado em: 2013-04
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5. TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I
The phosphorylation of cardiac troponin I (cTnI) plays an important role in the contractile dysfunction associated with heart failure. Human cardiac troponin I-interacting kinase (TNNI3K) is a novel cardiac-specific functional kinase that can bind to cTnI in a yeast two-hybrid screen. The purpose of this study was to investigate whether TNNI3K can phosphoryl
Braz J Med Biol Res. Publicado em: 01/02/2013
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6. Interação com alfa B-cristalina protege a FAK da degradação e promove a sobrevivência de miócitos cardíacos durante estresse mecânico = : Interaction with alfa B-crystalline protects FAK degradation and promotes survival of cardiac myocytes in mechanical stress / Interaction with alfa B-crystalline protects FAK degradation and promotes survival of cardiac myocytes in mechanical stress
Diversos tipos celulares respondem ao estresse mecânico ativando sinais que culminam com remodelamento e sobrevivência. O estresse mecânico pode atuar como agente modulador da homeostase celular e de numerosos processos patológicos. Evidências sugerem que a Quinase de Adesão Focal (FAK) medeia a resposta de miócitos cardíacos ao estresse mecânico. C
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/04/2012
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7. Liberação fracional de Ca2+ no modelo do retículo sarcoplasmático funcionalmente isolado : experimentação e modelamento matemático / Fractional Ca2+ release in the model of the functionally isolated sarcoplasmic reticulum : experimentation and mathematical modeling
A fração do conteúdo de Ca2+ do retículo sarcoplasmático (RS) liberada a cada contração (Fractional Release - FR) em miócitos cardíacos é regulada pela corrente de entrada de Ca2+ através da membrana celular pelos canais de Ca2+ tipo-L (ICa,L) e pelo conteúdo de Ca2+ do RS ([Ca2+]RS). Em trabalho anterior foi desenvolvido, no nosso laboratório,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/12/2011
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8. Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles
OBJECTIVES: We investigated the influence of sildenafil on cardiac contractility and diastolic relaxation and examined the distribution of phosphodiesterase-5 in the hearts of hypertensive rats that were treated with by NG-nitro-L-arginine methyl ester (L-NAME). METHODS: Male Wistar rats were treated with L-NAME and/or sildenafil for eight weeks. The Langend
Clinics. Publicado em: 2011
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9. Efeitos de um programa de exercício físico prévio ao infarto do miocárdio sobre a morfologia e a função contrátil do ventrículo esquerdo de ratos / Effects of a physical exercise program previous to myocardial infarction on the left ventricle morphology and contractile function of rats
The aim of this study was to verify the effects of a treadmill running program previous to myocardial infarction (MI) on the myocardium morphology and contractile function of rats. One-month old male Wistar rats were randomly divided into three groups: sedentary infarcted (INF SED, n = 13), exercised infarcted (INF EX, n = 26) and simulated infarction (SHAM,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/08/2010
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10. Efeitos do exercício físico sobre as propriedades morfológicas e mecânicas de miócitos cardíacos de ratos diabéticos / Effects of exercise on the morphological and mechanical properties of cardiac myocytes from diabetic rats
The aim of this study was to verify the effects of a swimming training (ST) on the morphological and mechanical properties of cardiac myocytes from different regions of the left ventricle (LV) of rats with experimental diabetes. One month old male Wistar rats (body mass ~ 250g) received an intraperitoneal injection of Streptozootocin (STZ, 60mg/kg body mass)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/04/2010
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11. Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats
We determined the effects of exercise training and detraining on the morphological and mechanical properties of left ventricular myocytes in 4-month-old spontaneously hypertensive rats (SHR) randomly divided into the following groups: sedentary for 8 weeks (SED-8), sedentary for 12 weeks (SED-12), treadmill-running trained for 8 weeks (TRA, 16 m/min, 60 min/
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-11
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12. Effect of tyrosine phosphatase Shp2 silencing on phenotypic changes of cardiomycytes and effect of mutations and deletion of Shp2 in the hearts of mjice subjected to mechanical stress / Efeito do silenciamento da tirosino-fosfatase Shp2 nas alterações fenotípicas dos miócitos cardíacos e efeito da deleção e mutações da Shp2 em corações de camundongos submetidos ao estresse mecânico
Estudos do nosso laboratório demonstraram que a quinase de adesão focal (FAK) é ativada e contribui para a regulação dos mecanismos de sinalização que determinam as alterações fenotípicas de cardiomiócitos submetidos a estímulos mecânicos. Em estudo anterior demonstramos através da inibição farmacológica da Shp2, que a mesma contribui para a
Publicado em: 2010