Tratamento coletivo da filariose com dose Ãnica de dietilcarbamazina em residentes de Ãrea endÃmica do Recife, Pernambuco:um estudo antes e depois / Collective treatment for filariasis with first dose dietilcarbamazin in residents of endemic areas of Recife, Pernambuco: a before-after study

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

In Recife, filariasis is considered endemic since 1950âs decade and remains as one of the major expression residual centers for autochthonous transmission of bancroftian filariasis in Brasil. The collective treatment in medium and high-prevalence areas, as WHO recommended strategy, has been integrated to antivectorial interventions. This study is part of an institutional project for filariasis elimination, which aims to evaluate the response to the collective treatmentâs first dose with dietilcarbamazin (DEC), in a dosage of six Âg/kg of weight in microfilaremic individuals residents in endemic areas of Alto Santa Terezinha and Ãgua Fria neighborhoods, both located in Sanitary District Two (DSII). A before-after study has been accomplished, employing results from filtration exams of 1 ml of blood per polycarbonate membrane and results from antigen research for Og4C3, carried out at pre and post-intervention moments amongst the whole studied group. 92 people of both sexes engaged the study, with age-group ranging from 3 to 78 years old, residents in endemic areas adscripted to Family Heath Program teams where the Filariasis Control Program is being developed, including vectorial control actions. The proportion of microfilaremics, microfilaremic density and antigenemy media have been compared before and after collective treatment with DEC. To compare the media, T-Test has been used; to compare the category variables, the X2 and the Statistical Significance through P-Value have been used. The analyses also considered sex and age-group. The reduction in microfilaremic individuals proportion, concerning the pre-intervention period, was statistically significant (p= 0,0000002). Considering <100mf/ml and ≥100mf/ml categories, the analyses showed a 47,8% to 16,3% reduction in individuals with microfilaremy ≥ 100mf/ml (p=0,002). The filarial density decreased from 55,1 mf/ml of blood to 6,67 mf/ml (p= 0,000) - a 87,9% reduction compared to the pre-intervention levels. Concerning antigenemy (Og4C3), the decrease was not statistically significant, which endorses consulted literature results. We conclude that people treated with single-dose DEC presented similar response to previous experiences with collective treatments, and this strategy may reduce microfilarial density and microfilaremics proportion in the population, substancially contributing to eliminate filariasis in the area

ASSUNTO(S)

filariose microfilaremia tratamento coletivo doencas infecciosas e parasitarias collective treatment dec microfilaremic filariasis dec

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