Targeting the Shikimate Pathway in the Malaria Parasite Plasmodium falciparum
AUTOR(ES)
McConkey, Glenn A.
FONTE
American Society for Microbiology
RESUMO
The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 × 10−5 and 2.7 × 10−4 M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89043Documentos Relacionados
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