Targeting the Shikimate Pathway in the Malaria Parasite Plasmodium falciparum
McConkey, Glenn A.
American Society for Microbiology
The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 × 10−5 and 2.7 × 10−4 M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.
ACESSO AO ARTIGOhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89043
- RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum
- Tetraethylthiuram disulfide (Antabuse) inhibits the human malaria parasite Plasmodium falciparum.
- Parasite virulence and disease patterns in Plasmodium falciparum malaria.
- Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle.
- Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum.