Sociodemographic characteristics and clinical features of patients with adult polycystic kidney disease undergoing hemodialysis; Características sociodemográficas e aspectos clínicos de pacientes com doença renal policística do adulto submetidos a hemodiá

DATA DE PUBLICAÇÃO

08/05/2015

RESUMO

AIMS: To analyze the sociodemographic and clinical characteristics of patients with adult polycystic kidney disease admitted to hemodialysis services in Northwestern Paraná state, Brazil. METHODS: This was an observational, descriptive and retrospective longitudinal study. Medical records of patients with polycystic kidneys who initiated hemodialysis between 1995 and 2012, in four centers that treat patients of the coverage area of the 15th Regional Health Region of Paraná state where analyzed. RESULTS: We found that 10.3% of hemodialysis patients had polycystic kidney disease as a leading cause of stage 5 of chronic kidney disease. The mean age of patients was 54.9±9.4 years (ranging between 27 and 74 years), with equal gender distribution and caucasian predominance (72.9%). The average age of dialysis initiation was 50±10.2 years. The most common comorbidity was systemic hypertension (66.7%). Liver cyst was the main extrarenal manifestation (10.4%). Twenty-five percent of the paients required renal transplantation, and (22.9%) undergone nephrectomy. The most widely used classes of antihypertensive drugs were β-blockers (41.7%) and drugs that act on the renin-angiotensin system (31.3%), while 56.3% of patients were treated with recombinant human erythropoietin. CONCLUSIONS: This is a pioneering epidemiological study in Northwestern Paraná state, describing the profile of patients with adult polycystic kidney disease undergoing hemodialysis. Due to the large ethnic variability in the region, more studies that describe the incidence and prevalence of the disease, as well as association studies, are needed.

ASSUNTO(S)

epidemiology hemodialysis autosomal dominant polycystic kidney disease epidemiologia doença renal policística autossômica dominante chronic kidney failure cistos doença renal crônica

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