Relação do hábito alimentar e polimorfismos da MTHFR C677T com a instabilidade genômica em fumicultores gaúchos

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

2012

RESUMO

Genetic damage can occur spontaneously under normal metabolic circumstances and can also be present in situations of dietary deficiency or inadequate intake of nutrients and excessive exposure to environmental mutagens. The purpose of this study was to evaluate the influence of the intake of micronutrients B12, B6 and folate and of polymorphism MTHFR C677T in the induction of DNA damage in individuals exposed to pesticides. The study involved 69 men and 41 women who were tobacco farmers in the region of Venâncio Aires (State of Rio Grande do Sul, Brasil). DNA damage was analyzed by the Comet Test and Micronucleus Test (MN); dietary intake was evaluated based on the mean of three 24-hour Diet Recall questionnaires. The nutrient intake data were computerized and estimated in the Food Processor SQL 10.9 program. The DNA damage results showed a significant increase in MN frequency in the lymphocytes of individuals who had an inadequate intake of folate and B12 (P = 0.030 and P = 0.014, respectively). No significant association was found between DNA damage and polymorphism MTHFR C677T. Correlations between DNA damage and polymorphism MTHFR C677T and nutrient intake were not significant. In conclusion, our results indicated that the adequate intake of folate (¿ 320 ¿g /day) and vitamin B12 (¿ 2,0 ¿g /day) can provide protection from the mutagenic action of pesticides. A dietary adaptation of folate and B12 can ensure adequate repair, showing that diet is a protective factor in this population.

ASSUNTO(S)

folate metabolism hábito alimentar tabaco dna damage nutrigenômica polymorphism mthfr c677t dano ao dna tobacco farmers rio grande do sul occupational exposed

ACESSO AO ARTIGO

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