Reactive oxygen species as signaling molecules of contraction-mediated metabolic responses in skeletal muscle. / Espécies reativas de oxigênio como sinalizadores das respostas metabólicas mediadas por contração no músculo esquelético.

AUTOR(ES)

Carlos Hermano da Justa Pinheiro

DATA DE PUBLICAÇÃO

2008

RESUMO

Contractile activity is a potent stimulus for induce changes in glucose and fatty acid metabolism in skeletal muscle. During muscle contraction, the production of reactive oxygen species (ROS) is increased. The purpose of this study was evaluate the effect of removal of ROS, induced by treatment with the antioxidant N-Acetylcysteine, on glucose uptake, activities of glycolytic and TCA cycle enzymes, lactate production, mitochondrial fatty acid oxidation, gene expression of glucose transporter 4 (GLUT-4), hexokinase II (HKII), phosphofructokinase 1 (PFK-1), carnitine palmitoyl transferase 1 (CPT-1) and citrate synthase (CS) mediated by moderate contractions induced by electrical stimulation in vitro. In this study we demonstrated that ROS act as signaling molecules on contraction-mediated metabolic responses and that redox signaling regulates glucose and fatty acid metabolism in skeletal muscle cells.

ASSUNTO(S)

espécies reativas de oxigênio metabolism of carbohydrate muscle contration cell metabolism metabolismo de gordura contração muscular skeletal muscle músculo esquelético metabolism of fat metabolismo celular metabolismo de carbohidrato reactive oxygen species

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