Proposta de utilização do vitrocerâmico anortita como um sistema de liberação de fármacos

AUTOR(ES)

Julio Cesar da Silveira Colpo

DATA DE PUBLICAÇÃO

2007

RESUMO

Anortita glass-ceramic is a biocompatible material that shows intelligent material properties, since its degradation occurs depending on pH variation. This characteristic is particularly interesting when regarding clinical applications in which the material should start degradation when in contact with biological fluids, like in temporary implants. The use of Anortita as a drug vehicle constitutes a new technology that may allow constant drug liberation, keeping an adequate therapeutical index, along with desired drug levels, thus facilitating treatment participation and efficacy, for example, when dealing with Parkinson s disease, a neurodegenerative process that affects most frequently elder people, and which treatment comprises oral administration of levodopa in doses that vary depending on disease duration and gravity. Anortita shows characteristics that are compatible with drug reservoir systems, and is able to store substances or other health-related materials inside its chambers, thus allowing the glassceramic to be used as drug transport or vehicle. In order to demonstrate that, five Anortita capsules were manufactured, using stainless steel casts. Capsule fabrication followed regular glass-ceramic manufacturing steps, such as component mixture in predefined proportions, heating until fusion, encapsulating and cristalization. Capsules were filled with the testing drug (Prolopa HBS - Levodopa + Benzerazida) and underwent an in vitro essay, in which the pieces suffered immersion in tampon phosphate solution with pH 3.5 and 7.4. After this stage, mass analysis showed that the capsules lost mass, that is, material degradation occurred. Absorbance reading showed that the testing drug previously stored inside the capsules was released, pointing to the viability of further research trying to validate this biomaterial as a drug-release system.

ASSUNTO(S)

pottery farmacocinética engenharia biomédica - dissertações cerâmica vidro biomedical engineering glass biocompatibility pharmacokinetics biocompatibilidade engenharia medica

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