Pre-clinical study of gastroprotective effect of mangiferin, a glucosylxanthone from Mangifera indica L., in experimental models of acute gastric mucosal injury / Estudos prÃ-clÃnicos do efeito gastroprotetor da mangiferina, uma glicosilxantona isolada de Mangifera indica L., em modelos experimentais de lesÃo gÃstrica aguda

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Mangiferin, a glucosylxanthone from the fruiting tree Mangifera indica Linn. (Anacardiaceae), was evaluated for the first time in acute models of gastric injury. Mangiferin (3, 10 and 30 mg/kg, p.o.) significantly attenuated (p<0,001) the gastric damage induced by ethanol (30, 35 and 63% of reduction), acidified ethanol (27, 44 and 78% of inhibition), indomethacin (22, 23 and 57% of reduction) and compound 48/80. This xanthonoid (30 mg/kg) markedly attenuated (p<0,01) the depletion of gastric mucosal non-protein sulfhydryl and the increase of malonyldialdehyde levels ethanol associated. While pretreatment with TRPV1 antagonist capsazepine (5 mg/kg, i.p.) failed to block effectively (p>0,05) the gastroprotective effect of mangiferin (30 mg/kg) against ethanol damage. Furthermore, the mangiferin effect was significantly (p<0,01) reduced in mice pretreated with indomethacin, L-NAME and glibenclamide. Mangiferin (30 mg/kg) caused significant diminutions (p<0,001) in gastric secretory volume and total acidity and significantly enhanced (p<0,001) gastric emptying in rats. Taken together, the results of this study strongly indicate a cytoprotective role for mangiferin affording gastroprotection against gastric damage induced by various ulcerogens, which is possibly mediated, in part, by endogenous prostaglandins, nitric oxide release, K+ ATP channel opening and antioxidant action

ASSUNTO(S)

antagonistas dos receptores h2 de histamina farmacologia xanthones mangifera indica anacardiaceae stomach ulcer mangifera indica anacardiaceae antiulcerosos plantas medicinais xantonas Ãlcera gÃstrica

ACESSO AO ARTIGO

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