PHYTOCHEMICAL ANALYSIS OF HYDROETHANOLIC EXTRACTS FROM POWDERED ROOTS OF Panax ginseng C. A. Meyer AND Heteropterys tomentosa A. Juss AND EVALUATION OF THEIR EFFECTS ON ASTROCYTE CELL DEATH
AUTOR(ES)
Bezerra, Andréia Gomes, Negri, Giuseppina, Duarte-Almeida, Joaquim Maurício, Smaili, Soraya Soubhi, Carlini, Elisaldo Araújo
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2016-06
RESUMO
The medicinal plants Panax ginseng C. A. Meyer (Araliaceae) and Heteropterys tomentosa A. Juss (Malpighiaceae) are widely and separately used by the Brazilian population as phytotherapeutics for the same medicinal purposes as tonics and to improve cognition. A chemical analysis was carried out on hydroethanolic extracts of powdered roots from P. ginseng and H. tomentosa using HPLC-DAD-ESI-MS/MS (High Performance Liquid Chromatography coupled to Diode-Array Detector and Electrospray Ionization - Mass Spectrum/Mass Spectrum). The ginsenosides Rg1, Rf, mRg and mRf were the main constituents in a hydroethanolic extract from P. ginseng, while in the hydroethanolic extract from H. tomentosa, caffeoylquinic acid derivatives and astilbin isomers were the main constituents. Concentration-time-effect curves were generated in cultures of astrocytes that were incubated with hydroethanolic extracts of these species to elucidate their toxicities. The P. ginseng extract was nontoxic at all of the tested times and concentrations. The hydroethanolic extract from H. tomentosa demonstrated toxicity at a concentration of 1000 µg/mL. P. ginseng extract had no protective effect against staurosporine. Many studies have demonstrated the neuroprotective effect of ginsenosides, caffeoylquinic derivatives and flavonoids.
Documentos Relacionados
- Ensaios farmacológicos clínicos com o extrato das raízes do Panax ginseng C. A. Meyer no controle da ansiedade
- Análise comparativa de embalagens secundárias e bulas de medicamentos contendo Panax ginseng C. A. Meyer
- Ensaio farmacológico clínico com extrato das raízes do Panax ginseng C. A. Meyer no tratamento da fibromialgia.
- Efeitos protetores do Panax Ginseng C. A. Meyer sobre a genotoxicidade da doxorrubicina em células somáticas de Drosophila melanogaster
- Efeito dos extratos de Panax ginseng, Turnera diffusa e Heteropterys tomentosa sobre a apoptose no hipocampo de ratos idosos