Phospholipase gene expression during Paracoccidioides brasiliensis morphological transition and infection
AUTOR(ES)
Soares, Deyze Alencar, Oliveira, Marilia Barros, Evangelista, Adriane Feijo, Venancio, Emerson Jose, Andrade, Rosangela Vieira, Felipe, Maria Sueli Soares, Petrofeza, Silvana
FONTE
Mem. Inst. Oswaldo Cruz
DATA DE PUBLICAÇÃO
2013-09
RESUMO
Phospholipase is an important virulence factor for pathogenic fungi. In this study, we demonstrate the following: (i) the Paracoccidioides brasiliensis pld gene is preferentially expressed in mycelium cells, (ii) the plb1 gene is mostly up-regulated by infection after 6 h of co-infection of MH-S cells or during BALB/c mice lung infection, (iii) during lung infection, plb1, plc and pld gene expression are significantly increased 6-48 h post-infection compared to 56 days after infection, strongly suggesting that phospholipases play a role in the early events of infection, but not during the chronic stages of pulmonary infection by P. brasiliensis.
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