Perfil lípidico, apolipoproteína A-I estresse oxidativo em atletas de futebol, sedentários e familiares.




Introduction - Lipid profile and the free radicals formation are influenced by many factors such as sedentary, obesity, tabagisme, diabetes, genetic characteristics among others. Lipid metabolism alterations recognized as dislipidemies and free radicals production increase may be associated to coronary arterial disease. In the last three decades countless papers were done relating plasmatic lipoprotein levels, oxidative stress and exercises to prevent diseases like atherosclerosis, being controvert the opinions regarding the type and intensity of the physical activity. Aim - Evaluate the physical activity influence and life habits in lipid serial levels, apoprotein A-I (apo A-I) and malondialdehido MDA comparing soccer players and sedentary individuals and their respective relatives. Casuistic and method - 157 individuals were studied between 17 and 21 years old: G1 20 professional soccer players, G2 20 academics with no regular physical activity, G3 60 relatives from G1 and G4 57 relatives from G2. Biochemical analyses included total cholesterol (TC), cholesterol fraction from high lipoprotein (HDLc), low (LDLc) and very low density (VLDLc), triglycerides (TG), apo A-I, (MDA) and glicemy. Statistic analyses considered significance for P<0,05. Results - Elevated values of TG were observed on G1 (147+ 134 mg/dL) compared to G2 (92,8+64,1 mg/dL; P= 0,12) although no significant difference between the groups. On G3 was noted an increase of TC and LDLc (148,3+36,9 mg/dL; 82,4+37,7 mg/dL) in relation to G1 (119,5+37,9 mg/dL; 53,6+30,3 mg/dL; P=0,018; P=0,006, respectively). In compensation G1 showed elevated levels of HDLc (49,7+8,48 mg/dL) and reduced level of A-I apo (116,7+11,9 mg/dL) in relation to G3 (42,7+7,7 mg/dL; P=0,003; 124,6+10,2 mg/dL; P=0,026, respectively). MDA values from G1 showed to be smaller (101,0+77,0 ng/mL) in relation to G2 (290,0+341,0 ng/mL; P=0,025) and to G3 (209,0+197,5 ng/mL; P=0,036). Considering glicemy it was noted an increase on G1 (90,2+12,2 mg/dL) compared to G2 (74,1+14,7 mg/dL; P=0,001) and to G3 (79,7+34,4 mg/dL;P= 0,264). Conclusion There are associations between reduced levels of MDA and regular practicing of physical exercises, suggesting decrease of oxidative stress in soccer players. Further more, prevalent alteration in TG levels in this group seems to be associated to elevated ingestion of carbohydrates, what must be investigated. Physical exercises practicing by athletes, although without any influence in lipid profile, whose values are similar to sedentary subjects, seems to reduce the oxidative stress, once more elevated values of MDA are associated to obesity and sedentary. Unequal proportion between the athletes and their relatives related to reduced levels of HDLc and similar between the controls and their relatives, reinforce the influence of physical activity with the increase of HDLc levels.


apolipoproteína a-i exercício-fisiologia farmacia estresse oxidativo

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