Niveis dos receptores soluveis de transferrina e graus de maturidade dos reticulocitos na talassemia alfa+

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

Background and Objective. It has been suggested that an increased number of young circulating red blood cells (RBC) in a+-thalassemic children could be related to the high frequencies of the a+-thalassemic allele in malaria endemic areas. Reticulocyte (RET) evaluation in this condition, however, has not been performed so far. Our objective was to determine the RET number and maturation degree, in addition to the soluble transferrin receptor (sTfR) and serum erythropoietin (s-Epo) levels, in a+-thalassemia heterozygotes from Southeastern Brazil, an area not subjected to malaria. Design and Methods. We studied 121 a+-thalassemia carriers (-a3.7/aa) (T) and 249 normal controls (aa/aa) (C), sub-classified according to age [1-5 years (T=27;C=41), 6-10 (T=18;C=42), 11-15 (T=16;C=44), 16-20 (T=20;C=42) and over 20 (T=40;C=80)], all of them with normal ferritin levels. RET analyzes were performed by flow cytometry and the sTfR and s-Epo levels determined by immunonephelometry and chemiluminescence, respectively. Results. There was no statistical difference between T and C regarding the RET evaluation [percentages and absolute values, p=0.2643 and 0.5421; high, medium and low maturation degree, p=0.2579, 0.2196 and 0.4192; RET Maturity Index (RMI), p=0.2471, respectively], as well as the s-Epo levels (p=0.5711). The sTfR concentrations were higher in T (p=0.0001), reaching statistical significance in the 1-5 and over 20 subgroups (p=0.0082 and 0.0436, respectively). Interpretation and Conclusions. Although the higher sTfR levels, we could not observe any alteration in RET number and maturation in the a+-thalassemic population analyzed here, a region free from malaria. These results are compatible with a compensatory erythopoiesis

ASSUNTO(S)

malaria

ACESSO AO ARTIGO

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