Neutrophil-to-lymphocyte ratio and in-hospital mortality in patients with acute heart failure

AUTOR(ES)

Turfan, Murat, ErdoĞan, Ercan, Tasal, Abdurrahman, Vatankulu, Mehmet Akif, Jafarov, Parviz, Sönmez, Osman, Ertaş, Gökhan, Bacaksız, Ahmet, Göktekin, Ömer

FONTE

Clinics

DATA DE PUBLICAÇÃO

2014-03

RESUMO

OBJECTIVES: Previous studies have demonstrated the role of inflammation in acute heart failure. The neutrophil-to-lymphocyte ratio was found to be a useful inflammatory marker for predicting adverse outcomes. We hypothesized that an elevated neutrophil-to-lymphocyte ratio would be associated with increased mortality in acute heart failure patients. METHODS: The study cohort consisted of 167 acute heart failure patients with an ejection fraction <50%. The primary endpoint was in-hospital mortality, and the patients were divided into two groups according to in-hospital mortality. RESULTS: In a multivariate regression analysis, including baseline demographic, clinical, and biochemical covariates, the neutrophil to lymphocyte ratio remained an independent predictor of mortality (OR 1.156, 95% CI 1.001 - 1.334, p= 0.048). CONCLUSION: In conclusion, an elevated neutrophil-to-lymphocyte ratio seems to be a predictor of short-term mortality in patients with acute heart failure and a reduced left ventricular ejection fraction.

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