Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection

AUTOR(ES)

Fecury, Amanda Alves, Almeida, Marcella Kelly Costa de, Santos, Kemper Nunes dos, Freitas, Andrei da Silva, Dantas, Socorro de Fátima Loureiro, Costa, Carlos Araújo da, Crescente, Ângelo Barlleta, Sousa, Rita Catarina Medeiros de, Brito, Elza Baía de, Nassiri, Reza, Lampe, Elizabeth, Martins, Luisa Caricio

FONTE

Rev. Soc. Bras. Med. Trop.

DATA DE PUBLICAÇÃO

12/02/2014

RESUMO

Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.

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