Modelo experimental para pesquisa de linfonodo sentinela no penis do cÃo / Identification of sentinel lymph of inguinal region in dogs Model

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

17/12/2010

RESUMO

Cancer of the penis is a rare neoplasm in developed countries, but troubling in the countries of Latin America, Asia and Africa. In Brazil represents about 2% of male malignancies. Considering this incidence is estimated for 2010 some 160 new cases in CearÃ. Because there is a scarcity of publications on this disease, there are still numerous issues in their management. The penis has peculiar features of lymphatic drainage. In its treatment are carried out bilateral inguinal lymphadenectomy, which have high morbidity (infection and swelling of limbs). Cabanas first described the anatomical concept of sentinel lymph node which unfortunately did not win the reliability expected. Perhaps the disbelief in this procedure refers to the fact that few series deserve credibility, which hinders their diffusion as well as high rates of false negatives. Following the same line of sentinel lymph node in canine models for breast and stomach, this work aims to define an experimental model of sentinel lymph node in dog penis, using patent blue and technetium 99m phytate This model can serve both for training of professionals in the sentinel lymph node biopsy for penile cancer, how to evaluate other feasible research methods that can be brought into clinical practice. Procedures were used in 19 dogs, healthy adult, mixed breed, weighing between 10 and 20kg. Infiltrated 0.2 ml of saline containing Technetium 5μCi the leading edge of the glans penis (shaft 12h), after 10 minutes injected with 0.5 mL of patent blue in one place. Waiting over 10 minutes was searched with the probe transcutaneously hot spots in the inguinal and iliac chains. In this place an incision was made and evaluated with the probe sentinel lymph node in-vivo and ex vivo, writing down the values. Registered lymph nodes stained and not stained with blue dye was performed statistical analysis and intercession of the two methods. It is observed in this study, the identification of 94.76% of the SLN. There was no statistical difference between right and left sides (P>0.05) and there was good correlation between the methods of patent blue staining and labeling with technetium (kappa: 0.642) on the right and perfect correlation between the methods the left ( kappa: 1) indicating a good consistency in the procedures. Based on these results, we can conclude that research in the penis linfondo sentry dog is feasible

ASSUNTO(S)

pÃnis biÃpsia de linfonodo sentinela cirurgia cirurgia tecnÃcio desenvolvimento experimental

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